Association of PD-1+ Treg/PD-1+ CTL Ratio and TLS with Prognosis and Response in Advanced Gastric Cancer
April, 2025
Researchers used advanced imaging and analysis tools from TissueGnostics to detect and quantify two cell types, the PD-1+ regulatory T cells (Treg)/PD-1+CD8+ cytotoxic T cells (CTL) ratio, and tertiary lymphoid structure (TLS) presence in tumor tissue.
Epigenetic Carcinogenesis: Quantitative Insights from HistoQuest Analysis
May, 2025
The evolving understanding of cancer biology underscores the pivotal role of epigenetic modifications - heritable yet reversible changes in gene expression that do not alter the DNA sequence.
Read more: White Paper Epigenetic Carcinogenesis: Quantitative Insights from HistoQuest Analysis
Advanced Imaging Reveals Why Some Breast Cancers Resist Treatment
September, 2025
Breast cancer continues to affect millions of people around the world—and for most, the diagnosis involves a hormone receptor-positive subtype.1
Read more: White Paper Advanced Imaging Reveals Why Some Breast Cancers Resist Treatment
Integrative Multiomics Approach Unveils Systemic Dysfunction in Colorectal Cancer (CRC)
October, 2025
A recent study, published in Clinical and Translational Medicine, provides new insights into the colorectal cancer (CRC) immune macroenvironment, identifying key clinical biomarkers that could help stratify CRC patients for immune checkpoint inhibitor (ICI) therapies.
Improving the Efficacy of Immunotherapy in Lung Cancer Through Novel Target Discoveries
October, 2024
The researchers elucidated the role of the B7-H4 ligand in lung cancer, using spatial tissue cytometry solutions.
Multimodal Spatial Biology Approach Reveals a Novel Cancer-Associated Fibroblast (CAF) Subset in HNSCC
September, 2024
The team of scientists identified a new CAF subset in HNSCC combining tissue cytometry and spatial transcriptomics
Algorithmic automation of bone research with StrataQuest
July, 2024
A team from the Medical University of Vienna, Austria, developed an algorithm to automatically detect and quantify osteoclasts within StrataQuest image analysis software.
Read more: White Paper Algorithmic automation of bone research with StrataQuest
Understanding Glioblastoma, One Cell at a Time
June, 2024
Spatial transcriptomics and tissue cytometry can be synergistically combined to verify the results or deepen the understanding of TME processes both on mRNA and protein level
Read more: White Paper Understanding Glioblastoma, One Cell at a Time
Analysis of Organoid and Immune Cell Co-Cultures By Machine Learning-Empowered Image Cytometry
April, 2024
The StrataQuest Organoid App provides reliable and efficient high-throughput validation and quantification for organoids co-cultured alongside immune cells.
The Role of Cytolytic CD8+ T Cells in Suppressing Ongoing HIV Replication in Spontaneous Controller Lymph Nodes
November, 2023
Using TissueGnostics’ tissue cytometry solutions, a recent study revealed important information on how sustained cytolytic CD8+ T cells are central in determining long-term viral control in lymph nodes (LNs). This further elucidates the mechanisms behind the immune control over cancerous diseases, which may be used to develope treatments strategies for more effective results and better patient outcomes.
Characterizing the Tumor Microenvironment of Colorectal Cancer Patients
October, 2023
A 50-year-old patient with MSS-type CRC and PD-L1-negative recurrent hepatopulmonary metastases underwent complete remission and prolonged benefits from immunotherapy treatments after systematic treatments had previously failed.
Read more: White Paper Characterizing the Tumor Microenvironment of Colorectal Cancer Patients
Researching the Role of Immune Checkpoints, IDO1 and PDL1, to Study Cutaneous Leishmaniasis
November, 2023
In this interview we speak with Dr. Nidhi Dey, University of York, presents her exciting new work on the spatial analysis of IDO1 and PDL1 checkpoints in cutaneous leishmaniasis.
Activated Erk 1/2 Kinases Decrease Cell Viability Caused by Erastin in HNSCC
June, 2023
Using TissueFAXS whole-slide imaging and HistoQuest single cell analysis solution, a recent study revealed that xCT inhibition, caused by erastin, may be a promising therapeutic approach for treating HNSCC tumorous cells through the initiation of cell ferroptosis.
Read more: White Paper Activated Erk 1/2 kinases decrease cell viability caused by erastin in HNSCC
TissueFAXS Chroma and StrataQuest analysis to identify potential targets for therapies against colorectal liver metastases
October, 2022
Colorectal cancer is the second most common cause of cancer-related mortality. One novel approach in cancer treatment is to target the anti or pro tumoral immune response. It has been reported that CD103+CD39+CD8+ TRM cells are present at higher levels in CRLM relative to adjacent liver tissue. These specific subpopulations of CD8 cells have now been evaluated in detail using the TissueFAXS CHROMA imaging platform and StrataQuest image analysis software.
Characterizing the Complex Microenvironment of Individual Immune Cells
April, 2019
Research groups from Yale University, USA published a paper in 'Cytometry' focusing on the phenotyping, quantification and visualization of immune cells and immune cell clusters within tissue sections using co-registration and IF multiplexed tissue cytometry.
Anti-Neoplastic Effects of Calcium in Colorectal Cancer Potentiated by Active Vitamin D
Febuary, 2015
Groups from Vienna published a paper in 'The Journal of Steroid Biochemistry and Molecular Biology' about Vitamin D potentiating the anti-neoplastic effects of calcium in the colon.
Read more: White Paper Anti-Neoplastic Effects of Calcium (2)
DNA-Binding of the Tet-Transactivator Curtails Antigen-Induced Lymphocyte Activation in Mice
October, 2017
Research groups from Austria, Australia, England and The Netherlands published a paper in 'Nature Communications' about the Tet-transactivator imparing the antigen-induced lymphocyte activation in mice.
Quantitative Comparison and Reproducibility of Pathologist Scoring and Digital Image Analysis of Estrogen Receptor β2 Immunohistochemistry in Prostate Cancer
July, 2016
Research groups from USA, published a paper in 'Diagnostic Pathology' dealing with quantitative comparison and reproducibility of pathologist scoring and digital image analysis in prostate cancer.
Imaging of neural contributions to voluntary hand movement
Febuary, 2019
Skilled motor behavior requires the precise exchange of information between the muscles of the body and various levels of the central nervous system (CNS). Motor behavior, limb mechanics and neural control must be precisely coordinated in order to achieve the required movement1.
Tumor Specific Regulatory T Cells in the Bone Marrow of Breast Cancer Patients Selectively Upregulate the Emigration Receptor S1P1
Febuary, 2017
Groups from Germany (Heidelberg, Jena) published a paper in the Journal 'Cancer Immunology, Immunotherapy' regarding tumor-specifc regulatory T cells in the bone marrow of breast cancer patients.
COVID-19 Shows a Loss of Bcl6-Expressing T Follicular Helper Cells and Germinal Centers
August, 2020
A groundbreaking publication in the journal Cell suggests that in COVID-19 patients the differentiation of Tfh cells and formation of germinal centers within lymph nodes and spleen is inhibited. Molecules such as Bcl-6 were assessed using the TissueFAXS platform including the analysis applications StrataQuest and TissueQuest.
Mediating Palatability-Guided Food and Water Consumption with Hindbrain Double Negative Feedback
October, 2020
Striosomes Causal Changes in Task Engagement
Febuary, 2021
Learning through affective responses, in which experiences are regarded as having a positive or negative valence (e.g., pleasure or fear, respectively), requires a judgment of the relative value of options. Several studies have linked a cluster of neurons in the subcortical basal ganglia, known as the striatum, to learning these valence-based responses (1,2)
Understanding HCC (Hepatocellular Carcinoma) Development and Progression
May, 2021
Liver cancer is the fourth leading cause of cancer-related death worldwide, of which hepatocellular carcinoma (HCC) is the most common primary cancer accounting for 75-85% of cases. HCC can be classified into several histological subtypes, reflecting the heterogeneity of the disease. This heterogeneity, including the cancers’ cell plasticity, is known to be, in part, determined by the microenvironment.
Evaluating the Nature of Immune Responses to Implanted Polypropylene Mesh
July, 2021
Redefine the Transcriptional and Epigenetic Signature of Tissue-associated Regulatory T Cells
September, 2021
Recently Delacher and colleagues were able to redefine the transcriptional and epigenetic signature of tissue-associated regulatory T cells (Treg) in mice and humans (Delacher et al. 2021). They could demonstrate, that Treg cells from healthy tissues share distinct expression patterns with tumor-infiltrating Treg cells.
Enhancing CAR-T Cell Therapy for Glioblastoma
October, 2021
Surgery, chemotherapy and radiation have formed the mainstay of cancer therapy for many years. However, in addition to destroying tumor cells, these treatments are detrimental to healthy cells giving rise to side effects, which can be severe. During the last two decades, more targeted therapies that specifically destroy cancer cells have been developed to minimize unwanted side effects.
Read more: White Paper Enhancing CAR-T therapy for glioblastoma (1)
PD-L1 raises new hope in the treatment of cutaneous leishmaniasis
January, 2022
IBEX and StrataQuest image analysis compatibility
May, 2022
One of the challenges of imaging tissue sections is dealing with their diverse composition. The human body contains hundreds of different cell phenotypes, with many more to be discovered. There is a huge need for multiplexing imaging techniques that can recover imaging information on cell-cell interactions with sufficient resolution to identify various unique phenotypes and is compatible with the diversity of cell species.
Read more: White Paper IBEX and StrataQuest image analysis compatibility (1)
Comprehensive Tissue Cytometry Analysis of CD3+ T cells in Lungs of COVID-19 Patients
June, 2022
More Articles …
- White Paper Activated Erk 1/2 kinases decrease cell viability caused by erastin in HNSCC
- White Paper Beyond Genetics: Exploring the Role of Epigenetic Modification in Chronic Lymphocytic Leukemia
- White Paper Type I interferon and CD8+ T cell detection help to predict the response to neoadjuvant treatment of rectal adenocarcinoma
