Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Read the Publication
Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

Read the Publication
AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Read the Publication
Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

Read the Publication
COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Read the Publication
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Read the Publication
Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Read the Publication
Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Read the Publication
Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Read the Publication
Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Read the Publication
Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

Read the Publication
SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Read the Publication
CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Read the Publication
previous arrow
next arrow

Filter publications

Customer Publications (A total of 3421 papers published)

Results 1 - 10 of 3421
01
Study on analgesic effect and mechanism of sophoridine oxide on neuropathic pain model mice

F Cheng, L Shi, X Zhang, Y Hu, K Gao

Chinese Journal of Clinical Pharmacology and Therapeutics (Magtech) China , 30 September 2025

Neuroscience

Organism: Mouse

Tissue: Brain

Pathological State: Chronic Constriction Injury

02
Facilitation of natural killer T-cell cytotoxic activity in uterine sarcoma via the CKS2-PI3K-AKT-MICA axis

Y Du, T Lan, M Liu, W Wu, J Ma

Translational Cancer Research (AME) China , 28 September 2025

Oncology

Key words: Uterine sarcoma, cyclin-dependent kinase regulatory subunit 2 (CKS2), natural killer T (NKT), major histocompatibility complex class I chain-related protein A (MICA), immune escape

Organism: Human

Tissue: Uterus

Pathological State: Cancer

03
Plumbagin improves pulmonary vascular remodeling in PAH via miR-21-5p/MMP/TIMP regulation, with diagnostic implications for cardiac function

CC Hsieh, HF Kuo, HH Wang, MDS Hua, IL Chen, JL Lin, YC Lo, ZJ Lin, YH Chen, YR Kuo, CH Hsu, PL Liu

Biomedicine & Pharmacotherapy (Elsevier) Taiwan , 27 September 2025

Cardiology

Key words: Plumbagin, Pulmonary arterial hypertension, miR-21–5p, BMPR2, TIMP-3

Organism: Mouse

Tissue: Lung

Pathological State: Hypertension

04
Gut symbiont-derived ursodeoxycholic acid promotes fatty acid oxidation to protect against renal ischemia-reperfusion injury

M Xie, J Zheng, Y Yu, Q Yang, Z Zhou, J Xue, B Wang, Y Qiu, Z Zhu, Q Sun, X Shi, W Shangguan, L Li, Z Zou, J Zhao, P Wu

Cell Reports Medicine (Cell) China , 26 September 2025

Nephrology

Key words: renal ischemia-reperfusion injury, gut microbiome, ursodeoxycholic acid, lipid metabolism, fatty acid oxidation, peroxisome proliferator-activated receptor-gamma, acute kidney injury, bile acid, gut-kidney axis, Eubacterium limosum

Organism: Human

Tissue: Kidney

Pathological State: Ischemia

05
A new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy

M Tian, Y Zhang, Z Liu, N Zhao, D Huang, J Hou, L Sun, Y Jiang, G Zhang, Y Ma

PloS one (PLOS) China , 25 September 2025

Hepathology

Key words: Mitochondria, Lipids, Hepatocytes, Autophagic cell death, Medical hypoxia, Mouse models, Fatty liver, Hypoxia,

Organism: Mouse

Tissue: Liver

Pathological State: Fatty Liver Disease

06
Astroglia-Mediated Neuroinflammation as a Putative Mechanism of Neurological Outcomes in COVID-19? Insights from a Brazilian Cohort

E Segabinazi, FR Tocantins, T Glaser, T Maglio, NC Oliveira, AG Castanha, FB Russo, PEC Leite, A Brito, CV Molina, GP Paludo, RdO Souza, SRM Alves, MdP Cunha, H Ulrich, EL Durigon, PC Beltrão-Braga, P Minoprio

Brain Behavior and Immunity (Elsevier) Brazil, France , 25 September 2025

Virology

Key words: SARS-CoV-2, neuroCOVID-19, astrocytes, neuroinflammation, disease modeling

Organism: Human

Pathological State: Viral Infection

Cell Line: hiPSCs

07
Cryo-EM structure of the full-length LGR4-RSPOs complex and a targeting nanobody for anti-obesity therapy

L Wang, H Qiao, H Jiang, S Guo, Y Li, N Zhang, T Geng, Q Cui, Z Lan, J Hong, W Gu, R Liu, G Ning, J Li, J Wang, Y Geng

Nature Communications (Nature) China , 25 September 2025

Pharmacology

Key words: Antibody therapy, Cryoelectron microscopy, Obesity, Target validation, Thermodynamics

Organism: Mouse

Tissue: Liver

Pathological State: Adipose

08
Proteomic analysis of chronically inflamed intestine and disease-related strictures in Crohn's disease patients

J Alfredsson

(Gothenburg University Library) Sweden , 24 September 2025

Gastroenterology

Key words: Crohn’s Disease, Strictures, Fibrosis, Proteomics, Spatial analysis

Organism: Human

Pathological State: Crohn's Diesease

Cell Line: EpCAM⁺CD45⁻

09
Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

MC Rominger, S O'Brien, S Gupta, S Moorthi, M McSharry, S Kamlapurkar, AR Lowe, A Waldum, A Lo, F Duke, F Wu, MB Headley, E Cromwell, R Glabman, A Koehne, AH Berger

Cell Reports (Cell) USA , 24 September 2025

Oncology

Key words: lung cancer, GTPase, epithelial-to-mesenchymal transition, Hippo, YAP, RAS, RIT1, AP-1, EMT, GEMM

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

10
Developing a Functional Osteoarthritis Model Using Human Osteochondral–Synovial Explants

L Labusca, CM Zara-Danceanu, AE Minuti, C Stavila, A Petrovici, P Plamadeala, I Ivanov, F Zugun-Eloae, D Anita, A Anita, N Lupu

Tissue Engineering Part A (MARY ANN LIEBERT) Romania , 23 September 2025

Osteology

Key words: Arthroplasty, Medicine, Surgery, Diagnosis, Orthopedic surgery, Surgical and operative procedures

Organism: Human

Tissue: Mesenchymal Cells

Pathological State: Obesity

Results 1 - 10 of 3421

LogoOrangewhite2025

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact us

About Us

TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

Keep in Touch

Be the first to hear about the latest scientific updates



We use cookies

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies).
You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.

Ok Decline
More information