Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 51 - 60 of 3421
51
Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

C Sheng, T Li, H Lin, X Ma, F Zhou, M Li, Y Wang, S Wang, J Tan, J Chen, Y Yang, Y Bi, J Lu, X Wang, L Zhou

Advanced Science (Wiley Online Library) China , 12 August 2025

Hepathology

Key words: 2-aminoadipic acid, amino acids, CBP/p300, GCDH, gluconeogenesis, histone crotonylation, type 2 diabetes

Organism: Mouse

Tissue: Liver

Pathological State: Diabetes

52
Amentoflavone inhibits colorectal tumor growth, stemness, and metastasis, prolonging survival through GLI-1/IL6/STAT3 axis targeting

YJ Fang, CH Chen, HJ Ku, DC Dong, TL Liao, FT Hsu

Biomedicine & Pharmacotherapy (Elsevier) Taiwan , 11 August 2025

Oncology

Key words: Amentoflavone, GLI-1, IL-6/STAT3, G1-arrest, stemness, metastasis

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

53
Taurine as a Protective Metabolite in Radiation-Induced Liver Disease: Evidence from 1H NMR Metabolomics

YH Chung, CC Weng, F Jhang, G Lin, CF Yu, FH Chen

Journal of Proteome Research (ACS Publications) Taiwan , 11 August 2025

Hepathology

Key words: Anatomy, Metabolism, Monomers, Peptides and proteins, Rodent models, 1H NMR metabolomics, radiation-induced liver diseases, taurine, preclinical study

Organism: Mouse

Tissue: Liver

Pathological State: Liver Disease

54
Prx1+ progenitors give rise to new articular cartilage when conditions are permissive for endogenous regeneration

CL Jablonski, D Modrcin, J Cobb, DM McCafferty, PT Salo, RJ Krawetz

Regenerative Medicine (NPJ) Canada , 09 August 2025

Cell Biology

Key words: Mesenchymal stem cells, Osteoarthritis

Organism: Mouse

Tissue: Bone

55
Regulation of cortical neurogenesis by MED13L via transcriptional priming and its implications for MED13L syndrome

J Li, Y Hao, J Cui, X Cao, N Wu, J Ma, S Xie,Y Pan, X He, Y Zhao, X Yuan

Communications Biology (Nature) China , 08 August 2025

Neuroscience

Key words: Developmental disorders, Neurodevelopmental disorders

Organism: Mouse

Tissue: Brain

Pathological State: MED13L

56
ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation

W Zhang, W Ren, S Guo, H Han, W Cai, H Bai, L Li, X Jiang, X Zheng, T Zhang, Y Wang, H Ye, H Cao, W Shi, H Zhou, Z Yu, L Qin, Z Jiao

Cell Death & Disease (Nature) China , 08 August 2025

Oncology

Key words: Immunosuppression, Translational research

Organism: Human, Mouse

Tissue: Stomache

Pathological State: Cancer

57
Therapeutic blockade of platelet-derived growth factor receptor-like protein attenuates cartilage degeneration and modulates cytokines in a spontaneous osteoarthritis mouse model

SWN Ueng, YH Hsu, YC Lin, CC Hu, YT Chiu, Y Chang, MF Chen

International Immunopharmacology (Elsevier) Taiwan , 07 August 2025

Osteology

Key words: Platelet-derived growth factor receptor-like (PDGFRL), STR/ort mice, Human cartilage plugs, Chondrocyte, SOX9, OARSI score

Organism: Mouse

Tissue: Bone

58
Pathological regression patterns following neoadjuvant chemo-immunotherapy in head and neck squamous cell carcinoma: a pilot study

D Wang, F Zeng, S Zhang, WM Hu, Y Wang, D Ouyang, B Zeng, G Zeng, J Li, G Liao, Y Liang

Frontiers in Immunology (Frontiers) China , 06 August 2025

Oncology

Key words: chemo-immunotherapy, neoadjuvant therapy, head and neck squamous cell carcinoma (HNSCC), regression pattern, pathological response

Organism: Human

Tissue: Mouth

Pathological State: Cancer

59
Effect of neoadjuvant chemotherapy on the clinical outcomes and immune microenvironment in oral squamous cell carcinoma

Z You, T Zhang, M Liu, J Wen, Y Wu, S Zhang

Journal of Cranio-Maxillofacial Surgery (Elsevier) China , 05 August 2025

Oncology

Key words: Neoadjuvant chemotherapy, Oral squamous cell carcinoma, Tumor immune microenvironment, CD8+PDL1+ cells, Multiplex immunofluorescence

Organism: Human

Tissue: Mouth

Pathological State: Cancer

60
Endothelial PRMT7 prevents dysfunction, promotes revascularization and enhances cardiac recovery post-myocardial infarction

TTV Tran, Y Zhang, S Wei, J Lee, Y Jeong,TA Vuong, SJ Lee, D Ryu, GU Bae, JS Kang

Experimental and Molecular Medicine (Nature) Korea , 05 August 2025

Cardiology

Key words: Cardiovascular diseases, Genetics research

Organism: Mouse

Tissue: Heart

Pathological State: Myocardial Infarction

Results 51 - 60 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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