Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

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Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 41 - 50 of 3421
41
Spatial regulation of CD8+ T cells at the HLA-E-NKG2A axis drives HIV persistence in lymph node B cell follicles

AO Papadopoulos, L Mvaya, T Khaba, N Ngema, W Smidt, S Msipa, B Mahlobo, T Ngubane, K Dong, I Jajbhay, J Pansegrouw, K Jambo, Z Ndhlovu

Cell Reports (Cell) South Africa, Malawi, USA, UK , 23 August 2025

Virology

Key words: HIV reservoir, spatial transcriptomics, lymph node immune regulation, CD8 T cell regulation, HLA-E

Organism: Human

Tissue: Lymph Node

Pathological State: Viral Infection

42
Induced Chondrocyte Ablation Disrupts Articular Cartilage Homeostasis but Is Not a Driver of Degeneration

AO Masson, JM Corpuz, K Corpuz, JA Biernaskie, WB Edwards, RJ Krawetz

Faseb Journal (Wiley Online Library) Canada , 21 August 2025

Osteology

Organism: Mouse

Tissue: Bone

43
Maternal liver lipid dysregulation mediates fetal developmental impairments induced by gestational co-exposure to ozone and heat in C57BL/6J Mice

Y Guo, J Zhang, X Jiang, M Li, W Li, Y Yang, L Chen, X Xing, Q Wang, Y Xiao, D Li, C Liao, W Chen, S Chen

Ecotoxicology and Environmental Safety (Springer) China , 20 August 2025

Enviormental Science

Key words: Development toxicity, Co-Exposure to ozone and heat, Global warming, Air pollution, Lipid metabolism, Placenta

Organism: Mouse

Tissue: Liver

Pathological State: Chemical Exposure

44
ZBED4: A Prognostic Biomarker and Therapeutic Target in Hepatocellular Carcinoma

J Ding, X Zou, X Huang, L Yu, H Hong, T Lin

Journal of Hepatocellular Carcinoma (Taylor & Francis) China , 20 August 2025

Oncology

Key words: ZBED4, pan-cancer, hepatocellular carcinoma, immune infiltration, therapy, prognosis

Organism: Human

Tissue: Liver

Pathological State: Cancer

45
Taurine alleviated paraquat-induced oxidative stress and gut-liver axis damage in weaned piglets by regulating the Nrf2/Keap1 and TLR4/NF-κB signaling pathways

C Chen, M Qi, W Zhang, F Chen, Z Sun, W Sun, W Tang, Z Yang, X Zhao, Z Tang

Journal of Animal Science and Biotechnology (Springer Nature) China , 18 August 2025

Hepathology

Key words: Antioxidant, Gut-liver axis, Immune response, Intestinal barrier, Lipopolysaccharide, Paraquat, Taurine, Weaned piglets

Organism: Pig

Tissue: Liver

Pathological State: Stress

46
Damaging effect of ischemia on the development of retinal organoids derived from human embryonic stem cells

YH Yan, HY Li, LX Gao, W Li, LP Zhao, Q Zeng, Y Luo, TT Cui, RG Zang, Z Ye, JF Xi, W Yue, ZH Li

International Journal of Ophthalmology (IJO Press) China , 18 August 2025

Opthalmology

Key words: retinal diseases, fetal ischemia, oxygen-glucose deprivation and reperfusion, human retinal organoids, retinal ganglion cells

Organism: Human

Pathological State: Ischemia

Cell Line: WA09

47
PSD3 as a context-dependent modulator of immune landscape and tumor aggressiveness in esophageal squamous cell carcinoma

S Luo, H Li, B Cai, A Nurbahati, H Cui, T Peng, W Wang, Q Liu, X Lu, S Zheng

Frontiers in Immunology (Frontiers) China , 15 August 2025

Oncology

Key words: esophageal squamous cell carcinoma, PSD3, PD-L1, TNFSF18, tumor microenvironment, immune infiltration, biomarker, multiplex immunohistochemistry

Organism: Human

Pathological State: Cancer

Cell Line: KYSE150

48
Lycium barbarum Polysaccharide Improves Iron Homeostasis in Spermatocytes and Sertoli Cells via NRF2 to Alleviate DEHP-Induced Male Reproductive Toxicity in Mice

Z Zhang, Y Shang, H Yang, L Ding, Y Deng, B Xu, X Fu

Toxics (MDPI) China , 14 August 2025

Reproductive Medicine

Key words: ferroptosis; NRF2; di-(2-ethylhexyl)phthalate; Lycium barbarum polysaccharide; Sertoli cell; spermatocytes

Organism: Mouse

Tissue: Testis

Pathological State: Chemical Exposure

49
The role of APOBEC mutagenesis in the progression and therapeutic guidance of pancreatic cancer

X Yu, G Shen, Z Liu, P Kaysar, X Shang, B Ni, W Zhang, Y Zhou, Y Xie, W Liu

Genomics (Elsevier) China , 12 August 2025

Oncology

Key words: APOBEC mutagenesis, Pan-cancer analysis, Immunotherapy, Prognosis

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

50
Cadherin 11 regulates presynaptic vesicle trafficking and neuronal activity in autism-related brain circuit

X Cao, J Jia, Z Li, S Guo, J Duan, J Ma, XB Yuan, YH Pan

Molecular Psychiatry (Nature) China , 12 August 2025

Neuroscience

Key words: Autism spectrum disorders, Neuroscience

Organism: Mouse

Tissue: Brain

Results 41 - 50 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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