Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 3231 - 3240 of 3421
3231
Digital Transplantation Pathology: Combining Whole Slide Imaging, Multiplex Staining and Automated Image Analysis

K Isse, A Lesniak, K Grama, B Roysam, M I Minervini A J Demetris

American Journal of Transplantation (Wiley) USA , 04 November 2011

Transplantation Medicine

Key words: Allograft pathology, C4d, digital image, fibrosis, quantitative analysis, quantum dots, three-dimensional imaging

3232
Gas challenge–blood oxygen level-dependent (GC-BOLD) MRI in the rat Novikoff hepatoma model

Yang Guo, Ning Jin, Rachel Klein, Jodi Nicolai, Guang-Yu Yang, Reed A Omary, Andrew C Larson

Magnetic Resonance Imaging (Elsevier) USA , 04 November 2011

Oncology

Key words: Gas challenge–blood oxygen level dependent (GC-BOLD), MRI, Rat Novikoff hepatoma, Tumor angiogenesis, Tumor microvessel density

Organism: Rat

Tissue: Liver

Pathological State: Cancer

3233
Evaluation of Functional and Structural Alterations in Muscle Tissue after Short-Term Cold Storage in a New Tissue Preservation Solution

Wille T, Gonder S, Thiermann H,Seeger T,Rauen U, Worek F

Cells Tissues Organs (Karger) Germany , 01 November 2011

Regenerative Medicine

Key words: Muscle tissue, preservation solution

Organism: Mouse

Tissue: Muscle

3234
Epithelial Area Detection in Cytokeratin Microscopic Images Using MSER Segmentation in an Anisotropic Pyramid

Cristian Smochina, Radu Rogojanu, Vasile Manta, Walter Kropatsch

Pattern Recognition in Bioinformatics (Springer) Romania, Austria , 01 November 2011

Medical Image Analysis

Key words: Crypt segmentation, Anisotropic diffusion pyramid, MSER, Biomedical imaging, Pathology, Microscopy, Fluorescence microscopy, Image analysis

Organism: Human

Tissue: Colon

Pathological State: Cancer

3235
Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands

Kwi Young Kang, Hyun-Ok Kim, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Dong-Il Sun, Joo Yeon Jhun, Hye Jwa Oh, Sung-Hwan Park, Ho-Youn Kim

Arthritis Research and Therapy (Springer) South Korea , 26 October 2011

Rheumatology

Key words: Serum il-21, anti-ro ssa antibody, synovial membrane cell, labial salivary gland, il-21r expression, il-21 gene, anti-ro la antibody, salivary gland biopsy, tfh cell, ectopic germinal center, encephalitis, th17 cell, nkt cell, il-21 concentration, ductal cell

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's syndrome

3236
Regulation of Oocyte and Cumulus Cell Interactions by Intermedin/Adrenomedullin 2

Chia Lin Chang, Hsin-Shih Wang, Yung-Kuei Soong, Shang Yu Huang, Shun Yuan Pa, Sheau Yu Teddy Hsu

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) Taiwan, USA , 18 October 2011

Reproductive Medicine

Key words: Apoptosis, Bioinformatics, Cell Compartmentation, Cyclic AMP (cAMP), G Protein-coupled Receptors (GPCR), Ovary Peptide Hormones Adrenomedullin CGRP

Organism: Mouse

Tissue: Ovaries

3237
Sampling step importance in hierarchical semantic segmentation of microscopic images

Smochina C, Manta V, Kropatsch W

System Theory, Control, and Computing (IEEEXplore) Romania, Austria , 16 October 2011

Microscopy

Key words: Semantic segmentation of microscopic images

3238
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

Tanaya Shree, Oakley C Olson, Benelita T Elie, Jemila C Kester, Alfred L Garfall, Kenishana Simpson, Katherine M Bell-McGuinn, Emily C Zabor, Edi Brogi, Johanna A Joyce

Genes and Development (CSH Press) USA , 12 October 2011

Oncology

Key words: Cancer metastasis, chemotherapy, tumor microenvironment, proteolysis paclitaxel

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

3239
Activation-Induced Cytidine Deaminase (AID)-Associated Multigene Signature to Assess Impact of AID in Etiology of Diseases with Inflammatory Component

Diana Mechtcheriakova, Yury Sobanov, Gabriele Holtappels, Erika Bajna, Martin Svoboda, Markus Jaritz, Claus Bachert, Erika Jensen-Jarolim

PLoS One (PLOS) Austria, Belgium , 03 October 2011

Immunology

Key words: Immunity, inflamation

Organism: Human

Tissue: Mucosa

Pathological State: Rhinosinusitis, Nasal polyps

3240
Evaluating the role of connexin43 in congenital heart disease: Screening for mutations in patients with outflow tract anomalies and the analysis of knock-in mouse …

GY Huang, LJ Xie, KL Linask, C Zhang, XQ Zhao, YI Yang, GM Zhou, YJ Wu, L Marquez-Rosado, DB McElhinney, E Goldmuntz, C Liu, PD Lampe, B Chatterjee, CW Lo

Journal of Cardiovascular Disease Research (Elsevier) USA, China , 01 October 2011

Cardiology

Key words: Connexin43, congenital heart disease, gap junction, knock-in mouse model, outflow tract, phosphorylations

Organism: Mouse

Tissue: Heart

Pathological State: Heart disease

Results 3231 - 3240 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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