Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3421 papers published)

Results 3211 - 3220 of 3421
3211
An Essential Role for Modulation of Hyperpolarization-Activated Current in the Development of Binaural Temporal Precision

Sukant Khurana, Zhiqiang Liu, Alan S Lewis, Kristen Rosa, Dane Chetkovich, Nace L Golding

Journal of Neuroscience (SFN) USA , 22 February 2012

Neuroscience

Key words: Medial superior olive, binaural neurons, hyperpolarization-activated current, cyclic nucleotide-gated (HCN) channels

Organism: Other Rodent

Tissue: Brain

3212
Regulation of Axonal HCN1 Trafficking in Perforant Path Involves Expression of Specific TRIP8b Isoforms

Wiebke Wilkars, Zhiqiang Liu, Alan S Lewis, Travis R Stoub, Elena M Ramos, Nicola Brandt, Daniel A Nicholson, Dane M Chetkovich, Roland A Bender

PLoS One (PLOS) Germany, USA , 21 February 2012

Neuroscience

Key words: Neurons, neuronal dendrites, axons, neuronal differentiation, immunohistochemistry techniques, pyramidal cells, in situ hybridization, hippocampus

Organism: Mouse, Rat

Tissue: Brain

3213
Inhibition of CD26/DPP-IV enhances donor muscle cell engraftment and stimulates sustained donor cell proliferation

Maura H Parker, Carol Loretz, Ashlee E Tyler, Lauren Snider, Rainer Storb, Stephen J Tapscott

Skeletal Muscle (Springer) USA , 16 February 2012

Regenerative Medicine

Key words: Muscular dystrophy, cell transplantation, xenotransplant, canine, CXCR4, diprotin A

3214
Combined strategies of apomorphine diester prodrugs and nanostructured lipid carriers for efficient brain targeting

Kuo-Sheng Liu, Chih-Jen Wen, Tzu-Chen Yen, K C Sung, Ming-Chuan Ku, Jhi-Joung Wang, Jia-You Fang

Nanotechnology (IOP Science) Taiwan, Saudi Arabia , 10 February 2012

Nanomedicine

Key words: nanostructured lipid carriers, diacetyl apomorphine, diisobutyryl apomorphine, DAA, DIA

Organism: Mouse

Tissue: Brain

3215
Optimisation of the diffractive optical element for snapshot spectral imaging used in fluorescence microscopy

R Leitner, T Arnold, M De Biasio, G McGunnigle, R Rogojanu, G E Steiner, A Hermerschmidt

Computational Microscopy (SPIE) Austria, Germany , 09 February 2012

Microscopy

Key words: Luminescence, microscopy, optical components, maging spectroscopy, cameras, reconstruction algorithms, spectral resolution, spectrometers, imaging systems, computed tomography

3216
Polycaprolactone electrospun mesh conjugated with an MSC affinity peptide for MSC homing in vivo

Zhenxing Shao, Xin Zhang, Yanbin Pi, Xiaokun Wang, Zhuqing Jia, Jingxian Zhu, Linghui Dai, Wenqing Chen, Ling Yin, Haifeng Chen, Chunyan Zhou, Yingfang Ao

Biomaterials (Elsevier) China , 07 February 2012

Biomaterials

Key words: Phage display, tssue engineering (TE), MSC-homing, peptide-modified polycaprolactone electrospun mesh

Organism: Rat

3217
Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial

Seema A Khan, Robert T Chatterton, Nancy Michel, Michelle Bryk, Oukseub Lee, David Ivancic, Richard Heinz, Carola M Zalles, Irene B Helenowski, Borko D Jovanovic, Adrian A Franke, Maarten C Bosland, Jun Wang, Nora M Hansen, Kevin P Bethke, Alexander Dew, Margerie Coomes, Raymond C Bergan

Cancer Prevention Research (AACR Publications) USA , 05 February 2012

Oncology

Key words: breast cancer, breast epithelial proliferation, random fine-needle aspiration

Organism: Human

Tissue: Breast

3218
Single-walled carbon nanotubes induce airway hyperreactivity and parenchymal injury in mice

WY Hsieh, CC Chou, CC Ho, SL Yu, HY Chen, HYE Chou, JJW Chen, HW Chen, PC Yang

American Journal of Respiratory Cell and Molecular Biology (ATS Journals) Taiwan , 01 February 2012

Nanomedicine

Key words: single-walled carbon nanotubes, toxicity, matrix metalloproteinase2, cathepsin K, NF-κB

Organism: Mouse

Tissue: Lung

3219
Swine Leukocyte Antigen-DQ Expression and Its Regulation by Interferon-Gamma at the Maternal-Fetal Interface in Pigs

Mingoo Kim, Heewon Seo, Yohan Choi, Jangsoo Shim, Fuller W Bazer, Hakhyun Ka

Biology of Reproduction (SSR) South Korea , 01 February 2012

Reproductive Medicine

Key words: Endometrium female reproductive tract pig pregnancy reproductive immunology SLA-DQ uterus

3220
Modulating intestinal immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus

Mohammad W Khan, Mojgan Zadeh, Praveen Bere, Elias Gounaris, Jennifer Owen, Todd Klaenhammer, Mansour Mohamadzadeh

Immunotherapy (FSG) USA , 01 February 2012

Immunology

Key words: Microbe Lactobacillus acidophilus, lipoteichoic acid-deficient strain, dendritic cells and macrophages

Organism: Mouse

Tissue: Colon

Pathological State: Intestinal Inflammation

Results 3211 - 3220 of 3421

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

 

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