Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2961 - 2970 of 3451
2961
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix

Leila Akkari, Vasilena Gocheva, Jemila C Kester, Karen E Hunter, Marsha L Quick, Lisa Sevenich, Hao-Wei Wang, Christoph Peters, Laura H Tang, David S Klimstra, Thomas Reinheckel, Johanna A Joyce

Genes and Development (CSH Press) USA, Germany , 29 August 2014

Oncology

Key words: Cell invasion, cell migration, tumor microenvironment protease

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2962
Quantitative LA-ICP-MS imaging of platinum in chemotherapy treated human malignant pleural mesothelioma samples using printed patterns as standard

M Bonta, H Lohninger, V Laszlo, B Hegedus, A Limbeck

Journal of Analytical Atomic Spectrometry (Royal Society of Chemistry) Austria, Hungary , 29 August 2014

Oncology

Organism: Human

Tissue: Lung

Pathological State: Cancer

2963
Macrophage Migration Inhibitory Factor Triggers Chemotaxis of CD74+CXCR2+ NKT Cells in Chemically Induced IFN-γ–Mediated Skin Inflammation

Chia-Yuan Hsi, Chia-Ling Chen, Yee-Shin Lin, Trai-Ming Yeh, Tsung-Ting Tsai, Ming-Yuan Hong, Chiou-Feng Lin

The Journal of Immunology (American Association of Immunologists) Taiwan , 29 August 2014

Immunology

Key words: Human NK cell, macrophage migration inhibitory factor

Organism: Human

Cell Line: Isolated primary human blood cell

2964
Vascularization of primary and secondary ossification centres in the human growth plate

Sonja M Walzer, Erdal Cetin, Ruth Grübl-Barabas, Irene Sulzbacher, Beate Rueger, Werner Girsch, Stefan Toegel, Reinhard Windhager, Michael B Fischer

BMC Developmental Biology (Springer) Austria , 28 August 2014

Developmental Biology

Key words: Growth plate, vascularization, primary ossification centres, secondary ossification centres, progenitor cells

Organism: Human

Tissue: Bone

2965
Type I interferons have opposing effects during the emergence and recovery phases of colitis

Isabella Rauch, Eva Hainzl, Felix Rosebrock, Susanne Heider, Clarissa Schwab, David Berry, Dagmar Stoiber, Michael Wagner, Christa Schleper, Alexander Loy, Tim Urich, Mathias Müller, Birgit Strobl, Lukas Kenner,Thomas Decker

European Journal of Immunology (Wiley) Austria , 25 August 2014

Immunology

Key words: Colitis, inflammation, interferons, interleukin-1, microbiota

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

2966
Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation

Anna M Weihs, Christiane Fuchs, Andreas H Teusch, Joachim Hartinger, Paul Slezak, Rainer Mittermayr, Heinz Redl§,Wolfgang G Junger, Harald H Sitte, Dominik Rünzler

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) Austria , 12 August 2014

Regenerative Medicine

Key words: ATP Cell proliferation, extracellular signal-regulated kinase (ERK), signal transduction, wound healing, shock wave treatment

Organism: Rat

Tissue: Skin

2967
Histological Characterization and Quantification of Cellular Events Following Neural and Fibroblast(-Like) Stem Cell Grafting in Healthy and Demyelinated CNS Tissue

Jelle Praet, Eva Santermans, Kristien Reekmans, Nathalie de Vocht, Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Herman Goossens, Zwi Berneman, Niel Hens, Annemie Van der Linden, Peter Ponsaert

Animal Models for Stem Cell Therapy (Springer) Belgium , 04 August 2014

Stem Cell Research

Key words: Neural stem cell, mouse embryonic fibroblasts, cell grafting, cuprizone, quantitative histology, inflammation

2968
Analysis of tumour-and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

Lisa Sevenich, Robert L Bowman, Steven D Mason, Daniela F Quail, Franck Rapaport, Benelita T Elie, Edi Brogi, Priscilla K Brastianos, William C Hahn, Leslie J Holsinger, Joan Massagué, Christina S Leslie and Johanna A Joyce

Nature Cell Biology (Nature) USA , 03 August 2014

Oncology

Key words: Cancer microenvironment, Metastasis

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

2969
Benzyl butyl phthalate induces migration, invasion, and angiogenesis of Huh7 hepatocellular carcinoma cells through nongenomic AhR/G-protein signaling

Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Feng-Jie Lai, Kung-Kai Kuo, Hua-Lin Wu, Eing-Mei Tsai and Po-Lin Kuo

BMC Cancer (Springer) Taiwan , 01 August 2014

Oncology

Key words: Phthalate, Aryl hydrocarbon receptor, Angiogenesis, Migration, Hepatocellular carcinoma

Organism: Mouse

Tissue: Liver, Xenograft Tumor

Pathological State: Cancer

2970
The vitamin D system is deregulated in pancreatic diseases

Doris Hummel, Abhishek Aggarwal, Katalin Borka, Erika Bajna, Enikö Kállay, Henrik Csaba Horváth

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, Hungary, Switzerland , 30 July 2014

Oncology

Key words: Vitamin D, CYP24A1, VDR, CaSR, chronic pancreatitis, pancreatic ductal adenocarcinoma, pancreatic cancer

Organism: Human

Tissue: Pancreas

Results 2961 - 2970 of 3451

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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