Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2931 - 2940 of 3451
2931
Characterization and anti-tumor effects of chondroitin sulfate–chitosan nanoparticles delivery system

Chieh-Shen Hu, Sung-Ling Tang, Chiao-Hsi Chiang, Hossein Hosseinkhani, Po-Da Hong, Ming-Kung Yeh

Journal of Nanoparticle Research (Springer) Taiwan , 07 November 2014

Oncology

Key words: Cell uptake efficiency, hepg2 cell, dox concentration, chondroitin sulfate, encapsulation efficiency, chitosan nanoparticle, anthracycline, gold nanoparticle, disaccharide, hepg2 cell line, entrapment efficiency, tumor volume

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2932
The Pseudomonas aeruginosa type III translocon is required for biofilm formation at the epithelial barrier

Cindy S Tran, Stephanie M Rangel, Henrik Almblad, Arlinet Kierbel, Michael Givskov, Tim Tolker-Nielsen, Alan R Hauser, Joanne N Engel

PLoS Pathogens (PLOS) Uruguay, Singapore, Denmark, USA , 06 November 2014

Microbiology

Key words: Bacterial biofilms, Pseudomonas aeruginosa, Pulmonary imaging, Antibiotic resistance, Host cells Cell staining, Confocal microscopy, Mouse models

Organism: Mouse

Tissue: Lung

Pathological State: Pseudomonas Infection

2933
Pharmacological inhibition of TGFβ receptor improves Nkx2.5 cardiomyoblast-mediated regeneration

Wen-Pin Chen, Yuan-Hung Liu, Yi-Jin Ho, Sean M Wu

Cardiovascular Research (Oxford University Press) Taiwan, USA , 01 November 2014

Regenerative Medicine

Key words: Nkx2.5, Cardiomyoblast, TGFβ, Regeneration, Myocardial infarction

Organism: Mouse

Tissue: Heart

2934
GATA2 Regulates Differentiation Of Bone Marrow-Derived Mesenchymal Stem Cells

Mayumi Kamata, Yoko Okitsu, Tohru Fujiwara, Masahiko Kanehira, Shinji Nakajima, Taro Takahashi, Ai Inoue, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae

Haematologica (Ferrata Storti Foundation) Japan , 01 November 2014

Stem Cell Research

Key words: Bone marrow, stem cells

Organism: Human

Cell Line: BM-MSCs

2935
The role of cytokines and chemokines in the T-cell-mediated autoimmune process in alopecia areata

Taisuke Ito, Yoshiki Tokura

Experimental Dermatology (Wiley) Japan , 29 October 2014

Dermatology

Key words: Alopecia areata, chemokine, cytokine, immune privilege, swarm of bees

Organism: Mouse

Pathological State: Alopecia Areata

Cell Line: Th17 cells

2936
Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin

Ayako Nakamura-Ishizua, Keiyo Takubo, Masato Fujioka, Toshio Suda

Biochemical and Biophysical Research Communications (Elsevier) Japan , 24 October 2014

Hematology

Key words: Megakaryocytes, hematopoietic stem cells, thrombopoietin, niche, bone marrow

Organism: Mouse

Tissue: Bone Marrow

2937
Fenretinide: A Novel Treatment for Endometrial Cancer

Navdha Mittal, Saurabh Malpani, Matthew Dyson, Masanori Ono, John S Coon, Julie J Kim, Julian C Schink, Serdar E Bulun, Mary Ellen Pavone

PLoS One (PLOS) USA , 23 October 2014

Oncology

Key words: Cancer treatment, apoptosis, uterine cancer, vitamin A, gene expression, small interfering RNAs, retinoic acid, cancer therapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2938
Loss of Gsα Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors

Partha Sinha, Piia Aarnisalo, Rhiannon Chubb, Noriaki Ono, Keertik Fulzele, Martin Selig, Hamid Saeed, Min Chen, Lee S Weinstein, Paola Divieti Pajevic, Henry M Kronenberg, Joy Y Wu

Journal of Bone and Mineral Research (Wiley) USA, Finland , 20 October 2014

Rheumatology

Key words: Osteoblasts, GSA, mesenchymal progenitors, adipocytes

Organism: Mouse

Tissue: Adipose Tissue

2939
Role of fractalkine in the pathogenesis of primary Sjögren syndrome: increased serum levels of fractalkine, its expression in labial salivary glands, and the association with clinical manifestations

Jae Ho Lee, Seung-Ki Kwok, Seung Min Jung, Jennifer Lee, Jae-Seon Lee, Seung Ye Baek, Eun-Kyung Kim, Ji Hyeon Ju, Sung-Hwan Park and Ho-Youn Kim

Journal of Rheumatology (jrheum.org) South Korea , 15 October 2014

Rheumatology

Key words: SJÖGREN SYNDROME, FRACTALKINE, CX3CR1

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

2940
Langerhans cells promote early germinal center formation in response to Leishmania-derived cutaneous antigens

Nicole Zimara, Christian Florian, Maximilian Schmid, Bernard Malissen, Adrien Kissenpfennig, Daniela N Männel, Matthias Edinger, James A Hutchinson, Petra Hoffmann, Uwe Ritter

European Journal of Immunology (Wiley) Germany, France, UK , 13 October 2014

Immunology

Key words: B cells, follicular helper, germinal center reaction, langerhans cells, leishmania major, T cells

Organism: Human

Pathological State: Leishmaniasis

Cell Line: B-Cells

Results 2931 - 2940 of 3451

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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