Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2891 - 2900 of 3451
2891
Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain

Costa R, Bergwerf I, Santermans E, De Vocht N, Praet J, Daans J, Le Blon D, Hoornaert C, Reekmans K, Hens N, Goossens H, Berneman Z, Parolini O, Alviano F, Ponsaerts P

Cell Transplantation (SAGE Journals) Italy , 01 February 2015

Transplantation Medicine

Key words: Fetal membrane-derived stromal cells, Embryonic fibroblasts, Immunomodulation, Transplantation, Brain, Angiogenesis

Organism: Mouse

Tissue: Brain

2892
Biomarkers in Lung Diseaes: from Pathogenesis to Prediction to New Therapies: A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle

Wilfred J Poppinga, Irene H Heijink, Laura J Holtzer, Philipp Skroblin, Enno Klussmann, Andrew J Halayko, Wim Timens, Harm Maarsingh, Martina Schmidt

American Journal of Physiology (APS Journals) The Netherlands, Germany, Canada, USA , 30 January 2015

Pulmonology

Key words: Compartmentalization, A-kinase-anchoring protein, inflammation, cyclic AMP, chronic obstructive pulmonary disease

Organism: Human

Cell Line: Human bronchial ASM cells

2893
The Major Birch Pollen Allergen Bet v 1 Induces Different Responses in Dendritic Cells of Birch Pollen Allergic and Healthy Individuals

Ursula Smole, Christian Radauer, Nina Lengger, Martin Svoboda, Neil Rigby, Merima Bublin, Sonja Gaier, Karin Hoffmann-Sommergruber, Erika Jensen-Jarolim, Diana Mechtcheriakova, Heimo Breiteneder

PLoS One (PLOS) USA, Austria, UK , 30 January 2015

Allergy Research

Key words: Allergens, cytokines, gene expression, pollen, immune response, fluorescence competition, monocytes, chemokines

Organism: Human

Pathological State: Allergy

Cell Line: iMoDCs ( immature monocyte-derived dendritic cells)

2894
Correlation of circular RNA abundance with proliferation–exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues

Anna Bachmayr-Heyda, Agnes T Reiner, Katharina Auer, Nyamdelger Sukhbaatar, Stefanie Aust, Thomas Bachleitner-Hofmann, Ildiko Mesteri, Thomas W Grunt, Robert Zeillinger and Dietmar Pils

Scientific Reports (Nature) Austria , 27 January 2015

Oncology

Key words: Cancer genetics, Epigenetics

Organism: Human

Tissue: Colon

Pathological State: Cancer

2895
Mapping spatial heterogeneity in the tumor microenvironment: a new era for digital pathology

Andreas Heindl, Sidra Nawaz, Yinyin Yuan

Nature (Nature) UK , 19 January 2015

Oncology

Key words: Tumor, digital pathology, mapping, spatial heterogeneity

2896
Loss of mitochondrial exo/endonuclease EXOG affects mitochondrial respiration and induces ROS-mediated cardiomyocyte hypertrophy

Wardit Tigchelaar, Hongjuan Yu, Anne Margreet de Jong, Wiek H van Gilst, Pim van der Harst, B Daan Westenbrink, Rudolf A de Boer, Herman H W Silljé

Cell Physiology (APS Journals) The Netherlands, China , 15 January 2015

Cardiology

Key words: Cardiomyocytes, hypertrophy, mitochondria, mitochondrial respiration, ROS

Organism: Rat

Pathological State: Cardiac Hypertrophy

Cell Line: NRVCs (neonatal rat ventricular cardiomyocytes)

2897
Down-regulation of TIMP-1 inhibits cell migration, invasion, and metastatic colonization in lung adenocarcinoma

Ying-Hua Chang, Yi-Jen Chiu, Hung-Chi Cheng, Fang-Ju Liu, Wu-Wei Lai, Hsiao-Jen Chang, Pao-Chi Liao

Tumor Biology (Springer) Taiwan, USA , 13 January 2015

Oncology

Key words: TIMP-1, migration, invasion, metastatic colonization, pericellular fibronectin assembly, lung adenocarcinoma

Organism: Human

Tissue: Lung

Pathological State: Cancer

2898
Localization of sunitinib, its metabolites and its target receptors in tumour-bearing mice: a MALDI-MS imaging study

S Torok, A Vegvari, M Rezeli, T E Fehniger, J Tovari, S Paku, V Laszlo, B Hegedus, A Rozsas, B Dome, G Marko-Varga

British Journal of Pharmacology (Wiley) Hungary, Austria, Sweden, Japan , 12 January 2015

Pharmacology

Key words: C-26 adenocarcinoma cells, matrix-assisted laser desorption ionization MS imaging, VEGF receptor-2

Organism: Mouse

Tissue: Allograft Tumor, Colon

Pathological State: Cancer

2899
Epitope topography controls bioactivity in supramolecular nanofibers

S Sur, F Tantakitti, JB Matson, SI Stupp

Biomaterials Science (Royal Society of Chemistry) USA , 09 January 2015

Nanomedicine

Key words: Epitope topography, bioactivity, nanofibers

Organism: Mouse

Cell Line: Mouse embryonic fibroblasts

2900
A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis

Tine Verreet, Roel Quintens, Debby Van Dam, Mieke Verslegers, Mirella Tanori, Arianna Casciati, Mieke Neefs, Liselotte Leysen, Arlette Michaux, Ann Janssen, Emiliano D'Agostino, Greetje Vande Velde, Sarah Baatout, Lieve Moons, Simonetta Pazzaglia, Anna Saran, Uwe Himmelreich, Peter Paul De Deyn, Mohammed Abderrafi Benotmane

Journal of Neurodevelopmental Disorders (Springer) Belgium, Italy, The Netherlands , 09 January 2015

Neuroscience

Key words: Apoptosis, Brain development, Cognitive dysfunction, MRI, Radiation

Organism: Mouse

Tissue: Brain

Results 2891 - 2900 of 3451

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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