Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2731 - 2740 of 3451
2731
Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease

Meliana Riwanto, Sarika Kapoor, Daniel Rodriguez, Ilka Edenhofer, Stephan Segerer, Rudolf P Wüthrich

PLoS One (PLOS) Switzerland , 11 January 2016

Nephrology

Key words: Kidneys, glycolysis, renal system, epithelial cells, glucose metabolism, apoptosis, ERK signaling cascade, polycystic kidney disease

Organism: Rat

Tissue: Kidney

Pathological State: Kidney Disease

2732
Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer

Leila Akkari, Vasilena Gocheva, Marsha L Quick, Jemila C Kester, Alison K Spencer, Alfred L Garfall, Robert L Bowman, Johanna A Joyce

Genes and Development (CHS Press) USA, Switzerland , 10 January 2016

Oncology

Key words: Cathepsin protease, compensatory mechanism, cancer

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

2733
Toll-Like Receptor 4 Is Essential in the Development of Abdominal Aortic Aneurysm

Chao-Han Lai, Kuan-Chieh Wang, Fang-Tzu Lee, Hung-Wen Tsai, Chih-Yuan Ma, Tsung-Lin Cheng, Bi-Ing Chang, Yu-Jen Yang, Guey-Yueh Shi, Hua-Lin Wu

PLoS One (PLOS) Taiwan , 07 January 2016

Immunology

Key words: Macrophages, immune receptor signaling, aneurysms, inflammation, toll-like receptors, aorta, small interfering RNAs, cytokines

Organism: Mouse

Tissue: Kidney

2734
The single-chain anti-TNF-a antibody DLX105 induces clinical and biomarker responses upon local administration in patients with chronic plaque-type psoriasis

Athanasios Tsianakas, Patrick M Brunner, Kamran Ghoreschi, Claudia Berger, Karin Loser, Martin Röcken, Georg Stingl, Thomas Luger, Thomas Jung

Experimental Dermatology (Wiley) Germany, Austria, Switzerland , 06 January 2016

Dermatology

Key words: Psoriasis, TNF-alpha, TNF-alpha-blocker

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

2735
3, 4-Dihydroxy-L-phenylalanine as a novel covalent linker of extracellular matrix proteins to polyacrylamide hydrogels with a tunable stiffness

Olaf Y Wouters, Diana TA Ploeger, Sander M van Putten, and Ruud A Bank

Tissue Engineering Part C (Mary Ann Liebert Inc.) The Netherlands , 05 January 2016

Regenerative Medicine

Key words: Tissue Enigneering, 3, 4-Dihydroxy-L-Phenylalanine, Linker, Extracellular Matrix, Hydrogel, Stiffness

Organism: Human

Cell Line: Human dermal fetal fibroblasts

2736
T1 Mapping by CMR Imaging : From Histological Validation to Clinical Implication

Andreas A Kammerlander, Beatrice A Marzluf, Caroline Zotter-Tufaro, Stefan Aschaue, Franz Duca, Alina Bachman, Klaus Knechtelsdorfer, Matthias Wiesinger, Stefan Pfaffenberge, Andreas Greiser Irene M Lang, Diana Bonderman, Julia Mascherbauer

JACC: Cardiovascular Imaging (Elsevier) Austria, Germany , 01 January 2016

Cardiology

Key words: CMR imaging, histological validation

Organism: Human

Tissue: Heart

2737
N-octanoyl dopamine attenuates the development of transplant vasculopathy in rat aortic allografts via smooth muscle cell protective mechanisms

J Wedel, MC Hottenrott, M Bulthuis, S Huitema, BA Yard, JK Hillebrands

Transplantation (Wolters Kluwer) The Netherlands, Germany , 01 January 2016

Transplantation Medicine

Key words: N-octanoyl Dopamine, Transplant Vasculopathy, Aortic Allografts, Smooth Muscle Cells, Protective Mechanisms

Organism: Rat

Tissue: Blood Vessels

2738
The anti-inflammatory compound curcumin enhances locomotor and sensory recovery after spinal cord injury in rats by immunomodulation

Lucia Machova Urdzikova, Kristyna Karova, Jiri Ruzicka, Anna Kloudova, Craig Shannon, Jana Dubisova, Raj Murali, Sarka Kubinova, Eva Sykova, Meena Jhanwar-Uniyal and Pavla Jendelova

International Journal of Molecular Sciences (MDPI) Czech Republic, USA , 31 December 2015

Neuroscience

Key words: spinal cord injury, curcumin, inflammation, cytokines, secondary processes, NF-κB

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

2739
Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

Elisabeth Strak, Isabella Ellinger, Christina Balthasar, Matthias Scheinast, Jasmin Schatz, Tamara Szattler, Sonja Bleichert, Leila Saleh, Martin Knöfler, Harald Zeisler, Markus Hengstschläger, Margit Rosner, Hans Salzer, Claudia Gundacker

Toxicology (Elsevier) Austria , 29 December 2015

Toxicology

Key words: Mercury, placenta, amino acid transporters

Organism: Human

Tissue: Placenta

2740
Long-term in vitro expansion of salivary gland stem cells driven by Wnt signals

Martti Maimets, Cecilia Rocchi, Reinier Bron, Sarah Pringle, Jeroen Kuipers, Ben NG Giepmans, Robert GJ Vries, Hans Clevers, Gerald de Haan, Ronald van Os, Robert P Coppes

Stem Cell Reports (Elsevier) The Netherlands , 24 December 2015

Stem Cell Research

Key words: In Vitro Expansion, Salivary Gland, Stem Cells, Wnt

Organism: Mouse

Tissue: Salivary Gland

Results 2731 - 2740 of 3451

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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