Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2701 - 2710 of 3451
2701
Acquisition of chemoresistance and other malignancy-related features of colorectal cancer cells are incremented by ribosome-inactivating stress

CK Oh, SJ Lee, SH Park, Y Moon

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) South Korea , 09 March 2016

Oncology

Key words: Ribosome-inactivating stress (RIS), Colorectal cancer, Activating transcription factor 3 (ATF3), Macrophage inhibitory cytokine-1 (MIC-1), Chemosensitivity

Organism: Mouse

Tissue: Allograft Tumor, Colon

Pathological State: Cancer

2702
Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach

Anastasia Meshcheryakova, Martin Svoboda, Ammar Tahir, Harald C Köfeler, Alexander Triebl, Felicitas Mungenast, Georg Heinze, Christopher Gerner, Philip Zimmermann, Markus Jaritz, and Diana Mechtcheriakova

Oncotarget (Impact Journals) Austria, Switzerland , 07 March 2016

Oncology

Key words: sphingolipid-related targets, sphingosine 1-phosphate/ceramide rheostat, multigene signature, epithelial to mesenchymal transition, lung cancer

Organism: Human

Pathological State: Cancer

Cell Line: Lung adenocarcinoma epithelial cell line A549

2703
Intrathecal transplantation of embryonic stem cell-derived spinal GABAergic neural precursor cells attenuates neuropathic pain in a spinal cord injury rat model

Insik Hwang, Suk-Chan Hahm Suk-Chan Hahm, Kyung-Ah Choi, Sung-Ho Park, Hyesun Jeong, Ji-Hye Yea, Junesun Kim, PhD, Sunghoi Hong, PhD

Cell Transplantation (SAGE Journals) South Korea , 01 March 2016

Regenerative Medicine

Key words: Spinal cord injury (SCI), Neuropathic pain, Spinal GABAergic neurons, Intrathecal transplantation

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

2704
Platelet-rich plasma influences expansion and paracrine function of adipose-derived stromal cells in a dose-dependent fashion

Willemsen, Joep C N, Spiekman, Maroesjka, Stevens, H P Jeroen, van der Lei, Berend, Harmsen, Martin C

Plastic and Reconstructive Surgery (Ingentaconnect) The Netherlands , 01 March 2016

Regenerative Medicine

Organism: Human

Tissue: Adipose Tissue

2705
Double Linear Gradient Biointerfaces for Determining Two-Parameter Dependent Stem Cell Behavior

Patrick Van Rijn, Philipp Kuhn, Qihui Zhou, Torben Van Der Boon, Aneta Schaap-Oziemlak, Theo Van Kooten

ChemNanoMat (Wiley) The Netherlands , 26 February 2016

Biological Methods

Key words: Biointerfaces, gradients, stem cell, wettability, stiffness

Organism: Human

Cell Line: Mesenchymal stem cells from human bone marrow (hBM-MSCs)

2706
Fenretinide: a potential treatment for endometriosis

Mary Ellen Pavone, Saurabh S Malpani, Matthew Dyson, J Julie Kim, Serdar E Bulun

Reproductive Sciences (SAGE Journals) USA , 25 February 2016

Reproductive Medicine

Key words: endometriosis, fenretinide, apoptosis, retinol, retinoid, STRA6, retinoic acid

Organism: Mouse

Tissue: Endometrium

Pathological State: Endometriosis

2707
Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice

Eva Bauer, Michaela Schlederer, Ruth Scheicher, Jaqueline Horvath, Petra Aigner, Ana-Iris Schiefer, Renate Kain, Heinz Regele, Gregor Hoermann, Günter Steiner, Lukas Kenner, Veronika Sexl, Andreas Villunger, Richard Moriggl, and Dagmar Stoiber

Oncotarget (Impact Journals) Austria , 23 February 2016

Oncology

Key words: ETV6/RUNX1, BCL2, glomerulonephritis, lymphoma, autoimmunity, Immunology and Microbiology Section, Immune response, Immunity

Organism: Mouse

Tissue: Kidney

2708
In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection

Xiaonan Zhang, Wei Lu, Ye Zheng, Weixia Wang, Lu Bai, Liang Chen, Yanling Feng, Zhanqing Zhang, and Zhenghong Yuan

The Journal of Clinical Investigation (American Society for Clinical Investigation) China , 22 February 2016

Virology

Key words: intrahepatic virological events, chronic hepatitis B virus infection

Organism: Human

Tissue: Liver

Pathological State: Hepatitis B Virus Infection

2709
In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain

Wardit Tigchelaar, Anne Margreet De Jong, Wiek H van Gilst, Rudolf A De Boer, Herman HW Silljé

Inside the Cell (Wiley) The Netherlands , 18 February 2016

Cell Biology

Key words: Cardiomyocyte, cell death, EXOG, hypertrophy, mitochondria

Organism: Rat

Cell Line: NRVC cells ( neonatal rat ventricular cardiomyocytes )

2710
Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies

M Sips, M Krykbaeva, T J Diefenbach, M Ghebremichael, B A Bowman, A-S Dugast, A W Boesch, H Streeck, D S Kwon, M E Ackerman, T J Suscovich, P Brouckaert, T W Schacker and G Alter

Mucosal Immunology (Nature) USA, Belgium, Germany , 17 February 2016

Key words: Cell signalling, HIV infections, Phagocytosis, Vaccines

Pathological State: HIV Infection

Results 2701 - 2710 of 3451

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