Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2681 - 2690 of 3451
2681
Tumor-associated B cells in cutaneous primary melanoma and improved clinical outcome

Kanika Garg, Margarita Maurer, Johannes Griss, Marie-Charlotte Brüggen, Ingrid H Wolf, Christine Wagnera, Niels Willi, Kirsten D Mertz, Stephan N Wagner

Human Pathology (Elsevier) Austria , 20 April 2016

Pathology

Key words: CD20, prognosis, melanoma, tumor microenvironment, tumor-associated B cells (TAB), tumor-infiltrating lymphocytes

Organism: Human

Tissue: Skin

Pathological State: Cancer

2682
Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

Ai-Ho Liao,Ying-Jui Lu, Yi-Chun Lin, Hang-Kang Chen, Huey-Kang Sytwu, Chih-Hung Wang

Theranostics (Ivyspring International Publisher) Taiwan , 11 April 2016

Oncology

Key words: Microbubbles, ultrasound, transdermal drug delivery, minoxidil, chitosan oligosaccharide lactate, hair growth

Organism: Pig, Mouse

Tissue: Skin

2683
Biocompatibility Assessment of a New Biodegradable Vascular Graft via In Vitro Co-culture Approaches and In Vivo Model

Marjan Enayati, Magdalena Eilenberg, Christian Grasl, Peter Riedl, Christoph Kaun, Barbara Messner, Ingrid Walter, Robert Liska, Heinrich Schima, Johann Wojta, Bruno K Podesser, Helga Bergmeister

Annals of Biomedical Engineering (Springer) Austria , 07 April 2016

Regenerative Medicine

Key words: Vascular graft, biocompatibility, biodegradable polyurethane, fibroblast-macrophage co-culture

Organism: Rat

Tissue: Blood Vessels

Pathological State: Organ Transplantation

2684
Dose-escalation study for the targeting of CD44v+cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Kohei Shitara, Toshihiko Doi, Osamu Nagano, Chiyo K Imamura, Takeshi Ozeki, Yuya Ishii, Kenji Tsuchihashi, Shunji Takahashi, Takako E Nakajima, Shuichi Hironaka, Miki Fukutani, Hiromi Hasegawa, Shogo Nomura, Akihiro Sato, Yasuaki Einaga, Takeshi Kuwata, Hideyuki Saya, Atsushi Ohtsu

Gastric Cancer (Springer) Japan , 07 April 2016

Oncology

Key words: Cancer stem cellCD44 variant positiveGastric cancerSulfasalazinexCT

Organism: Human

Tissue: Stomach

Pathological State: Cancer

2685
Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells

Bernd Schöpf, Georg Schäfer, Anja Weber, Heribert Talasz,Iris E Eder, Helmut Klocker, Erich Gnaiger

FEBS Journal (FEBS PRESS) Austria , 06 April 2016

Cell Biology

Key words: electron transfer system, high‐resolution respirometry, mitochondria, oxidative phosphorylation, prostate metabolism

Organism: Human

Tissue: Prostate

2686
Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression.

Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CV, Negroiu Gabriela

Journal of Biological Chemistry (American Society for Biochemistry and Molecular Biology) Romania , 06 April 2016

Oncology

Key words: Antigen processing, caveolin, epithelial-mesenchymal transition (EMT), melanoma, structural model

Organism: Human

Tissue: Skin

Pathological State: Cancer

2687
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Jonas Kloeppera,Lars Riedemanna, Zohreh Amoozgara,1, Giorgio Seanoa, Katharina Suseka, Veronica Yua, Nisha Dalviea, Robin L Amelunga, Meenal Dattaa,Jonathan W Songa,Vasileios Askoxylakisa, Jennie W Taylora,Christine Lu-Emersona,Ana Batistaa,Nathaniel D Kirkpatricka,Keehoon Junga, Matija Snuderla, Alona Muzikanskye, Kay G Stubenrauchf, Oliver Krieterf, Hiroaki Wakimotog, Lei Xu1, Lance L Munna, Dan G Dudaa, Dai Fukumuraa, Tracy T Batchelorc, Rakesh K Jaina,

PNAS (PNAS) USA , 04 April 2016

Oncology

Key words: Anti-angiogenic therapy, tumor microenvironment, anti-tumor immunity, macrophage polarization, microglia reprogramming

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

2688
CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma

Hagma H Workel, Fenne L Komdeur, Maartje CA Wouters, Annechien Plat, Harry G Klip, Florine A Eggink, G Bea A Wisman, Henriette JG Arts, Maaike HM Oonk, Marian JE Mourits, Refika Yigit, Marco Versluis, Evelien W Duiker, Harry Hollema, Marco de Bruyn, Hans W Nijman

European Journal of Cancer (Elsevier) The Netherlands , 31 March 2016

Oncology

Key words: Tumour-infiltrating lymphocytes, endometrial cancer, adenocarcinoma, CD103, survival

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

2689
Combining ultrasound and lactobacilli treatment for high-fat-diet-induced obesity in mice

A-H Liao, C-B Jiang, C-C Li, H-C Chuang, J-S Chiang Chiau, W-T Chan, C-Y Yeung, M-L Cheng, H-C Lee

Journal of Animal Physiology and Animal Nutrition (Wiley) Taiwan , 29 March 2016

Physiology

Key words: Actobacilli, ultrasound, high-fat-diet-induced obesity mice, micro-CT, fat deposition

Organism: Mouse

Tissue: Liver, Adipose Tissue

Pathological State: Obesity

2690
Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition

M Kuttke, E Sahin, J Pisoni, S Percig, A Vogel, D Kraemmer, L Hanzl, J S Brunner, H Paar, K Soukup, A Halfmann, A M Dohnal, C W Steiner, S Blüml, J Basilio, B Hochreiter, M Salzmann, B Hoesel, G Lametschwandtner, R Eferl, J A Schmidd and G Schabbauer

OncoImmunology (Taylor and Francis) Austria , 28 March 2016

Immunology

Key words: Colitis-associated colon cancer, myeloid Pi3K, tumor immune-surveillance

Organism: Mouse

Tissue: Xenograft Tumor, Colon

Pathological State: Cancer

Results 2681 - 2690 of 3451

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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