Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2391 - 2400 of 3451
2391
Angiogenin Attenuates Scar Formation in Burn Patients by Reducing Fibroblast Proliferation and Transforming Growth Factor β1 Secretion

SC Pan, CH Lee, CL Chen, WY Fang, LW Wu

Annals of Plastic Surgery (LWW Journals) Taiwan , 01 February 2018

Regenerative Medicine

Key words: angiogenin, fibroblast, scar, Smad2, transforming growth factor β1

Organism: Human

Tissue: Skin

Pathological State: Burn Wound

2392
Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of “luminal” muscle-invasive bladder cancers

Simon C Baker, Volker M Arlt, Radek Indra, Madeleine Joel, Marie Stiborová, Ian Eardley, Niaz Ahmad, Wolfgang Otto, Maximilian Burger, Peter Rubenwolf, David H Phillips, Jennifer Southgate

Molecular Carcinogenesis (Wiley) UK , 01 February 2018

Oncology

Key words: Urothelium, carcinogens, normal human urothelial (NHU) cells, EROD activity

Organism: Human

Cell Line: NHU cells (Normal human urothelial)

2393
Grey matter OPCs are less mature and less sensitive to IFNγ than white matter OPCs: consequences for remyelination

Dennis H Lentferink, Jacomien M Jongsma, Inge Werkman and Wia Baron

Scientific Reports (Nature) The Netherlands , 01 February 2018

Neuroscience

Key words: Multiple sclerosis (MS), central nervous system, oligodendrocyte progenitor cells (OPCs)

Organism: Rat

Cell Line: OPS cells (Oligodendrocyte progenitor cells)

2394
Assessing the selective therapeutic efficacy of superparamagnetic erlotinib nanoparticles in lung cancer by using quantitative magnetic resonance imaging and a nuclear factor kappa-B reporter gene system

Fei-Ting Hsu, Hua-Shan Liu, Ahmed Atef Ahmed Ali, Ping-Huei Tsai, Yu-Chieh Kao, Chia-Feng Lu, Hsu-Shan Huang Cheng-Yu Chen

Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier) Taiwan , 31 January 2018

Nanomedicine

Key words: Erlotinib, superparamagnetic iron oxide, magnetic resonance imaging, nuclear factor-κBNon-small-cell lung cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2395
Expression of cystatin C in the female reproductive tract and its effect on human sperm capacitation

Robert Kuo-Kuang Lee, Huan-Chin Tseng, Yuh-Ming Hwu, Chi-Chen Fan, Ming-Huei Lin, Jhih-Jie Yu, Ling-Yu Yeh and Sheng-Hsiang Li

Reproductive Biology and Endocrinology (Springer) Taiwan , 30 January 2018

Reproductive Medicine

Key words: Cystatin C (CST3), seminal plasma, sperm protein tyrosine phosphorylation

Organism: Human

Tissue: Uterus

2396
SPK1-transfected UCMSC has better therapeutic activity than UCMSC in the treatment of experimental autoimmune encephalomyelitis model of Multiple sclerosis

Yun-Liang Wang, Peng Xue, Chun-Yang Xu, Zhen Wang, Xin-Shan Liu, Lin-Lin Hua, Hong-Ying Bai, Zhi-Lei Zeng, Hai-Feng Duan and Jin-Feng Li

Scientific Reports (Nature) China , 29 January 2018

Neuroscience

Key words: Multiple Sclerosis (MS), central nervous system, permanent neurological damage, cytokine

Organism: Human

Cell Line: Human umbilical cord mesenchymal stem cells (HUC-MSC-SPK1)

2397
AXL promotes Zika virus infection in astrocytes by antagonizing type I interferon signalling

Jian Chen, Yi-feng Yang, Yu Yang, Peng Zou, Jun Chen, Yongquan He, Sai-lan Shui, Yan-ru Cui, Ru Bai, Ya-jun Liang, Yunwen Hu, Biao Jiang, Lu Lu, Xiaoyan Zhang, Jia Liu and Jianqing Xu

Nature Microbiology (Nature) China , 29 January 2018

Microbiology

Key words: Zika virus (ZIKV), neonatal microcephaly, Guillain–Barré syndrome, AXL

Organism: Insect

Pathological State: Zika Virus Infection, Guillain–Barré syndrome

Cell Line: C6/36 cells

2398
Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis

J B Wechsler, A Szabo, C L Hsu, R A Krier-Burris, H A Schroeder, M Y Wang, R G Carter, T E Velez, L M Aguiniga, J B Brown, M L Miller, B K Wershil, T A Barrett and P J Bryce

Mucosal Immunology (Nature) USA , 24 January 2018

Immunology

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

2399
Injectable hydroxyphenyl derivative of hyaluronic acid hydrogel modified with RGD as scaffold for spinal cord injury repair

Kristyna Zaviskova, Dmitry Tukmachev, Jana Dubisova, Irena Vackova, Ales Hejcl, Julie Bystronova, Martin Pravda, Ivana Scigalkova, Romana Sulakova, Vladimir Velebny, Lucie Wolfova, Sarka Kubinova

Journal of Biomedical Materials Research (Wiley) Czech Republic , 23 January 2018

Regenerative Medicine

Key words: Hydrogel, spinal cord injury (SCI), hydroxyphenyl derivative of hyaluronic acid (HA-PH)

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

2400
CCR5/CCL5 axis interaction promotes migratory and invasiveness of pancreatic cancer cells

Santosh Kumar Singh, Manoj K Mishra, Isam-Eldin A Eltoum, Sejong Bae, James W Lillard Jr and Rajesh Singh

Scientific Reports (Nature) USA , 22 January 2018

Oncology

Key words: Pancreatic cancer (PC), CCR5, CCL5, F-actin polymerization

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

Results 2391 - 2400 of 3451

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