Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2381 - 2390 of 3451
2381
Novel platforms of multiplexed immunofluorescence for study of paraffin tumor tissues

Edwin Roger Parra

Journal of Cancer Treatment and Diagnosis (Sciaccess Publishers) USA , 01 March 2018

Cytometry

Key words: Multiplexed proteins identification Immunofluorescence Signal Amplification Spatial Cell Distribution Image Analysis

2382
4:20 PM Abstract No. 350 Interferon-gamma-eluting microspheres for MRI-guided immunotherapy of liver cancer

WParkAGordonSChoXHuangKHarrisZZhangALarsonDKim

Journal of Vascular and Interventional Radiology (Elsevier) USA , 01 March 2018

Oncology

Organism: Rabbit

Tissue: Liver

Pathological State: Cancer

2383
In vitro behavior of human mesenchymal stem cells on poly(N-isopropylacrylamide) based biointerfaces obtained by matrix assisted pulsed laser evaporation

Madalina Icriverzi, Laurentiu Rusen, Livia Elena Sima, Antoniu Moldovan, Simona Brajnicov, Anca Bonciu, Natalia Mihailescu, Maria Dinescu, Anisoara Cimpean, Anca Roseanu, Valentina Dinca

Applied Surface Science (Elsevier) Romania , 28 February 2018

Cell Biology

Key words: pNIPAM coatings, MAPLE, mesenchymal stem cells

Organism: Human

Cell Line: Human mesenchymal stem cells (hMSCs)

2384
[18F]FEPPA: Improved Automated Radiosynthesis, Binding Affinity, and Preliminary in Vitro Evaluation in Colorectal Cancer

Neydher Berroterán-Infante, Theresa Balber, Petra Fürlinger, Michael Bergmann, Rupert Lanzenberger, Marcus Hacker, Markus Mitterhauser and Wolfgang Wadsak

ACS Medicinal Chemistry Letters (ACS Publications) Austria , 21 February 2018

Radiotherapy

Key words: Affinity, autoradiography, colorectal cancer, FEPPA, radiosynthesis, TSPO

Organism: Human

Tissue: Colon

Pathological State: Cancer

2385
CXCL5 facilitates melanoma cell-neutrophil interaction and lymph node metastasis

Ana Soler Cardona, Agnes Forsthuber, Katharina Lipp, Stefanie Ebersbergr, Magdalena Heinz, Klaudia Schossleitner, Elisabeth Buchberger, Mario Gröger, Peter Petzelbauer, Christoph Hoeller, Erwin Wagner, Robert Loewe

Journal of Investigative Dermatology (Elsevier) Austria , 21 February 2018

Dermatology

Key words: CXCL5, melanoma cells, chemokine mRNA expression

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2386
Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain

Yi-Chao Lee, Ying-Chao Chang, Chia-Ching Wu,Chao-Ching Huang

Molecular Neurobiology (Springer) Taiwan , 19 February 2018

Neuroscience

Key words: Neonatal brain injury, neurovascular protection, hypoxia-preconditioned, human umbilical vein endothelial cells, hypoxia-inducible factor 1-alpha

Organism: Human

Cell Line: HUVECs (Human umbilical vein endothelial cells)

2387
Inflammatory Monocytes Drive Influenza A Virus–Mediated Lung Injury in Juvenile Mice

Bria M Coates, Kelly L Staricha, Clarissa M Koch, Yuan Cheng, Dale K Shumaker, G R Scott Budinger, Harris Perlman, Alexander V Misharin and Karen M Ridge

The Journal of Immunology (American Association of Immunologists) USA , 14 February 2018

Immunology

Key words: Influenza A virus (IAV), NLRP3 inflammasome, cytokines, monocytes

Organism: Mouse

Tissue: Lung, Heart

2388
Preclinical In Vitro and In Vivo Evaluation of [18F]FE@SUPPY for Cancer PET Imaging: Limitations of a Xenograft Model for Colorectal Cancer

T Balber, JSinger, N Berroterán-Infante, M Dumanic, L Fetty, J Fazekas-Singer, C Vraka, L Nics, M Bergmann, K Pallitsch, H Spreitzer, W Wadsak, M Hacker, E Jensen-Jarolim, H Viernstein, and M Mitterhauser,

Contrast Media and Molecular Imaging (Wiley) Austria , 13 February 2018

Oncology

Key words: [18F]FE@SUPPY, Cancer PET Imaging, Colorectal Cancer

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

2389
Calcium signaling mediates five types of cell morphological changes to form neural rosettes

Hana Hříbková, Marta Grabiec, Dobromila Klemová, Iva Slaninová, Yuh-Man Sun

Journal of Cell Science (The Company of Biologists) Czech Republic , 12 February 2018

Neuroscience

Key words: Embryonic stem cells, neural stem cell niche, neural rosette formation, calcium, neurogenesis, adherens junctions, cytoskeleton proteins

Organism: Human

Cell Line: Human ESC-derived neural rosettes

2390
Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers

Junko Ohtsuka, Hiroko Oshima, Issei Ezawa, Ryo Abe, Masanobu Oshima and Rieko Ohki

Scientific Reports (Nature) Japan , 02 February 2018

Oncology

Key words: Gastric cancer, p53 mutations, tumour-suppressor proteins

Organism: Mouse

Tissue: Stomach

Pathological State: Cancer

Results 2381 - 2390 of 3451

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