Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

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Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

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SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 3091 - 3100 of 3451
3091
A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

Karoline Kollmann, Gerwin Heller, Christine Schneckenleithner, Wolfgang Warsch, Ruth Scheicher, Rene G Ott, Markus Schäfer, Sabine Fajmann, Michaela Schlederer, Ana-Iris Schiefer, Ursula Reichart, Matthias Mayerhofer, Christoph Hoeller, Sabine Zöchbauer-Müller, Dontscho Kerjaschki, Christoph Bock, Lukas Kenner, Gerald Hoefler, Michael Freissmuth, Anthony R Green, Richard Moriggl, Meinrad Busslinger, Marcos Malumbres, Veronika Sexl

Cancer Cell (Cell Press) Austria, UK, Spain , 12 August 2013

Oncology

Key words: Cell cycle kinase CDK6, pro-angiogenic factor VEGF-A, tumor suppressor p16INK4a

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

3092
Quantitative magnetization transfer MRI of desmoplasia in pancreatic ductal adenocarcinoma xenografts

Weiguo Li, Zhuoli Zhang, Jodi Nicolai, Guang-Yu Yang, Reed A Omary, Andrew C Larson

NMR in Biomedicine (Wiley) USA , 12 August 2013

Oncology

Key words: Quantitative magnetization transfer, bound proton fraction, desmoplasia, pancreatic cancer, xenograft

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

3093
Entry of human rhinovirus 89 via ICAM-1 into HeLa epithelial cells is inhibited by actin skeleton disruption and by bafilomycin

Beatrix Pfanzagl, Daniel Andergassen, Johanna Edlmayr, Katarzyna Niespodziana, Rudolf Valenta, Dieter Blaas

Archives of Virology (Springer) Austria , 04 August 2013

Virology

Key words: Hela cell, transferrin, rhabdomyosarcoma, confocal immunofluorescence microscopy, cholesterol depletion, dextran, skeletal muscle cell, stress fiber formation, actin aggregate, lipid raft, breast cancer cell line, infected hela cell, actin patch, rock inhibitor, capsid protein

Organism: Human

Cell Line: HeLa cells

3094
An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

Alicia S Chung, Xiumin Wu, Guanglei Zhuang, Hai Ngu, Ian Kasman, Jianhuan Zhang, Jean-Michel Vernes, Zhaoshi Jiang, Y Gloria Meng, Franklin V Peale, Wenjun Ouyang and Napoleone Ferrara

Nature Medicine (Nature) USA , 04 August 2013

Oncology

Key words: Cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

3095
Interleukin-1β induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis

Yasuyuki Shigematsu, Tohru Niwa, Emil Rehnberg, Takeshi Toyoda, Satoshi Yoshida, Akiko Mori, Mika Wakabayashi, Yoichiro Iwakura, Masao Ichinose, Yong-Joon Kim, Toshikazu Ushijima

Cancer Letters (Elsevier) Japan, South Korea , 03 August 2013

Oncology

Key words: Interleukin-1ß, gastric cancer, helicobacter pylori infection, inflammation

Organism: Mouse

Tissue: Stomach

Pathological State: Cancer, Helicobacter pylori infection

3096
Impact of constant storage temperatures and multiple warming cycles on the quality of stored red blood cells

T Wagner, M-A Pabst, G Leitinger, U Reiter, N Kozma, G Lanzer, B Huppertz

VoxSanguinis (Wiley) Austria , 02 August 2013

Hematology

Key words: Electron microscopy, quality, RBC, storage, temperature.

Organism: Human

Cell Line: Red blood cells

3097
Decreased hippocampal MR/GR ratio is associated with low-birth weight in Cynomolgus macaque neonates

JP Buschdorf, SX Ong, K Chng, MJ Meany

Journal of Molecular Endocrinology (Society for Endocrinology) Singapore , 01 August 2013

Reproductive Medicine

Key words: MR:GR ratio, cynomolgus macaque, glucocorticoid receptor, low birth weight

Organism: Monkey

Tissue: Brain

3098
Mobilizing monocytes to cross-present circulating viral antigen in chronic infection

Adam J Gehring, Muzlifah Haniffa, Patrick T Kennedy, Zi Zong Ho, Carolina Boni, Amanda Shin, Nasirah Banu, Adeline Chia, Seng Gee Lim, Carlo Ferrari, Florent Ginhoux, Antonio Bertolett

The Journal of Clinical Investigation (American Society for Clinical Investigation) Singapore, UK, Italy , 01 August 2013

Immunology

Organism: Human

Cell Line: PBMCs

3099
Infliximab induces downregulation of the IL-12/IL-23 axis in 6-sulfo-LacNac (slan)+ dendritic cells and macrophages

Patrick M Brunner, Frieder Koszik, Bärbel Reininger, Madeleine L Kalb, Wolfgang Bauer, Georg Stingl

Journal of Allergy and Clinical Immunology (Elsevier) Austria , 25 July 2013

Allergy Research

Key words: Psoriasis, myeloid dendritic cells, 6-sulfo-LacNac, IL-12p40, TNF-a

Organism: Human

Tissue: Skin

Pathological State: Psoriasis

3100
Association of gamma-glutamyltransferase with severity of disease at diagnosis and prognosis of ovarian cancer

C Grimm, G Hofstetter, S Aust, I Mutz-Dehbalaie, M Bruch, G Heinze, J Rahhal-Schupp, A Reinthaller, N Concin, S Polterauer

British Journal of Cancer (Nature) Austria, USA , 16 July 2013

Oncology

Key words: Ovarian cancer, Prognostic markers

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

Results 3091 - 3100 of 3451

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