Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Read the Publication
Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

Read the Publication
AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Read the Publication
Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

Read the Publication
COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Read the Publication
Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Read the Publication
Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Read the Publication
Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Read the Publication
Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Read the Publication
Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Read the Publication
Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

Read the Publication
SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

Read the Publication
CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Read the Publication
previous arrow
next arrow

Filter publications

Customer Publications (A total of 3451 papers published)

Results 2871 - 2880 of 3451
2871
Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells

Charlotte Gröschel, Abhishek Aggarwal, Samawansha Tennakoon, Julia Höbaus, Maximilian Prinz-Wohlgenannt, Brigitte Marian, Petra Heffeter, Walter Berger, Eniko Kállay

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria , 14 March 2015

Oncology

Key words: 1, 25-Dihydroxyvitamin D3, colorectal cancer, chemoprevention, wnt pathway, LGR5

Organism: Human

Tissue: Colon

Pathological State: Cancer

2872
Vimentin regulates activation of the NLRP3 inflammasome

Gimena dos Santos, Micah R Rogel, Margaret A Baker, James R Troken, Daniela Urich, Luisa Morales-Nebreda, Joseph A Sennello, Mikhail A Kutuzov, Albert Sitikov, Jennifer M Davis, Anna P Lam, Paul Cheresh, David Kamp, Dale K Shumaker, G R Scott Budinger and Karen M Ridge

Nature Communications (Nature) USA , 12 March 2015

Cell Biology

Key words: Cytoskeletal proteins, Inflammasome, NOD-like receptors, Respiratory tract diseases

Organism: Mouse

Tissue: Heart, Lung

2873
Nitric Oxide Prevents Alveolar Senescence and Emphysema in a Mouse Model

Amanda E Boe, Mesut Eren, Luisa Morales-Nebreda, Sheila B Murphy, G R Scott Budinger, Gökhan M Mutlu, Toshio Miyata, Douglas E Vaughan

PLoS One (PLOS) USA, Japan , 10 March 2015

Pulmonology

Key words: Nω-nitro-L-arginine methyl ester, alveolar tissue destruction, plasminogen activator inhibitor-1

Organism: Mouse

Tissue: Lung

Pathological State: Chronic Obstructive Pulmonary Disease

2874
Clinical improvement in psoriasis with specific targeting of interleukin-23

Tamara Kopp, Elisabeth Riedl, Christine Bangert, Edward P Bowman, Elli Greisenegger, Ann Horowitz, Harald Kittler, Wendy M Blumenschein, Terrill K McClanahan, Thomas Marbury, Claus Zachariae, Danlin Xu, Xiaoli Shirley Hou, Anish Mehta, Anthe S Zandvliet, Diana Montgomery, Frank van Aarle and Sauzanne Khalilieh

Nature (Nature) Austria, USA, Denmark , 09 March 2015

Dermatology

Key words: Psoriasis, interleukin-23

Pathological State: Psoriasis

2875
Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer

TT Wei, YC Lin, PH Lin, JY Shih, CW Chou, WJ Huang, YC Yang, PW Hsiao, CC Chen

Oncotarget (Impact Journals) Taiwan , 08 March 2015

Oncology

Key words: c-Cbl, EGFR, HDAC inhibitors, lung cancer

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

2876
Active vitamin D potentiates the anti-neoplastic effects of calcium in the colon: A cross talk through the calcium-sensing receptor

Abhishek Aggarwal, Julia Höbaus, Samawansha Tennakoon, Maximilian Prinz-Wohlgenannt, João Graça, Sally A Price, Petra Heffeter, Walter Berger, Sabina Baumgartner-Parzer, Enikö Kállay

The Journal of Steroid Biochemistry and Molecular Biology (Elsevier) Austria, UK , 07 March 2015

Oncology

Key words: Calcium-sensing receptor, Colon cancer, Calcium, Vitamin D, Chemoprevention, Calcimimetic

Organism: Mouse

Tissue: Colon

2877
Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation

Elias Gounaris, Michael J Heiferman, Jeffrey R Heiferman, Manisha Shrivastav, Dominic Vitello, Nichole R Blatner, Lawrence M Knab, Joseph D Phillips, Eric C Cheon, Paul J Grippo, Khashayarsha Khazaie, Hidayatullah G Munshi, David J Bentrem

PLoS One (PLOS) USA , 06 March 2015

Oncology

Key words: Calcium-sensing receptor, tumor suppressor, colorectal cancer, colon, calcium, calcimimetic, calcilytic

Organism: Mouse

Tissue: Intestine

Pathological State: Cancer

2878
Disruption of ​STAT3 signalling promotes ​KRAS-induced lung tumorigenesis

Beatrice Grabner, Daniel Schramek, Kristina M Mueller, Herwig P Moll, Jasmin Svinka, Thomas Hoffmann, Eva Bauer, Leander Blaas, Natascha Hruschka, Katalin Zboray, Patricia Stiedl, Harini Nivarthi, Edith Bogner, Wolfgang Gruber, Thomas Mohr, Ralf Harun Zwick, Lukas Kenner, Valeria Poli, Fritz Aberger, Dagmar Stoiber, Gerda Egger, Harald Esterbauer, Johannes Zuber, Richard Moriggl, Robert Eferl, Balázs Gy?rffy, Josef M Penninger, Helmut Popper,Emilio Casanova

Nature Communications (Nature) Austria, USA, Italy, Hungary , 03 March 2015

Oncology

Key words: Interleukin-6, oncostatin-M, epidermal growth factor, Lung cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

2879
16 Dectin-2 is essentially involved in innate immune response of experimental arthritis

V Stögner, T Shvets, B Niederreiter, M Koenders, WB van den Berg, JS Smolen, K Redlich, S Hayer

Annals of the Rheumatic Diseases (BMJ Journals) Austria, The Netherlands , 01 March 2015

Rheumatology

Key words: C-type lectin receptor Dectin-2, Toll-like receptors, myeloid cells

Organism: Mouse

Pathological State: Rheumatoid Arthritis

2880
Comparative Proteomic Analysis Reveals Activation of Mucosal Innate Immune Signaling Pathways during Cholera

Crystal N Ellis, Regina C LaRocquea, Taher Uddin, Bryan Krastins, Leslie M Mayo-Smith, David Sarracino, Elinor K Karlsson, Atiqur Rahman, Tahmina Shirin, Taufiqur R Bhuiyan, Fahima Chowdhury, Ashraful Islam Khan, Edward T Ryan, Stephen B Calderwood, Firdausi Qadri, Jason B Harris

Infection and Immunity (ASM) USA, Bangladesh , 01 March 2015

Immunology

Key words: Tissue microarray, Tissue cores, Population studies, Virtual microscopy, Data exchange, Standards Validation studies, Quality assurance, Donor block, Recipient block, Multitumo, r Tissue microarray, Progression tissue microarray, Prognosis tissue microarray, Normal tissue microarray, Frozen tissue microarray, Cell line tissue microarray, Xenograft tissue microarray, Cutting edge matrix assembly tissue microarray, Immunohistochemistry, Chromogenic in situ hybridization (CISH), Fluorescent in situ hybridization (FISH), Quantum dots, Multiplex immunoblotting, Hierarchical clustering analysis, Hierarchical naïve, Bayes model, Random forest clustering

Organism: Human

Tissue: Intestine

Pathological State: Cholera

Results 2871 - 2880 of 3451

LogoOrangewhite2025

TissueGnostics GmbH
Taborstraße 10/2/8
1020 Vienna, Austria
+43 1 216 11 90
This email address is being protected from spambots. You need JavaScript enabled to view it.

Contact us

About Us

TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

Keep in Touch

Be the first to hear about the latest scientific updates