Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2811 - 2820 of 3451
2811
Male-Specific Alleviation of Iron-Induced Striatal Injury by Inhibition of Autophagy

Li-Fang Wang, Kazunari K Yokoyama, Tzu-Yin Chen, Hsiu-Wen Hsiao, Pei-Chi Chiang, Ya-Ching Hsieh, Steven Lo, Chin Hsu

PLoS One (PLOS) Taiwan, USA , 06 July 2015

Neuroscience

Key words: Autophagic cell death, neurons, neostriatum, neuronal tuning, histology, DNA fragmentation, mice, ovariectomy

Organism: Mouse

Tissue: Brain

Pathological State: Stratial Injury

2812
T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine

Kristen L Dennis, Abdulrahman Saadalla, Nichole R Blatner, Shuya Wang, Vysak Venkateswaran, Fotini Gounari, Hilde Cheroutre, Casey T Weaver, Axel Roers, Nejat K Egilmez, Khashayarsha Khazaie

Cancer Immunology Research (AACR Publications) USA, Germany , 01 July 2015

Oncology

Key words: T -cell, IL10, tumor immune surveillance, small intestine

Organism: Mouse

Tissue: Intestine

2813
Membrane-bound Klotho is not expressed endogenously in healthy or uraemic human vascular tissue

Rik Mencke, Geert Harms, Katarina Mirkovic, Joyce Struik, Joris Van Ark, Ellen Van Loon, Melissa Verkaik, Martin H De Borst, Clark J Zeebregts, Joost G Hoenderop, Marc G Vervloet, Jan-Luuk Hillebrands

Cardiovascular Research (Oxford University Press) The Netherlands , 01 July 2015

Cardiology

Key words: Membrane-bound Klotho, uraemic human vascular tissue

Organism: Human

Tissue: Kidney, Blood Vessels

2814
Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons

Isabella Rauch, Felix Rosebrock, Eva Hainzl, Susanne Heider, Andrea Majoros, Sebastian Wienerroither, Birgit Strobl, Silvia Stockinger, Lukas Kenner, Mathias Müller, Thomas Decker

Molecular and Cellular Biology (ASM) Austria , 01 July 2015

Immunology

Key words: IRF9, intestinal inflammation, interferons

Organism: Mouse

Tissue: Colon

Pathological State: Colitis

2815
miR-22 and miR-29a are members of the androgen receptor cistrome modulating LAMC1 and Mcl-1 in prostate cancer

Lorenza Pasqualini, Huajie Bu, Martin Puhr, Narisu Narisu, Johannes Rainer, Bettina Schlick, Georg Schäfer, Mihaela Angelova, Zlatko Trajanoski, Stefan T Börno, Michal R Schweiger, Christian Fuchsberger, Helmut Klocker

Molecular Endocrinology (Oxford University Press) Austria, USA, Italy, Germany , 01 July 2015

Endocrinology, Oncology

Key words: miR-22, miR-29a, Androgen Receptor Cistrome, LAMC1, Mcl-1, Prostate Cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

2816
Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo

Fariba Poosti, Bao Tung Pham, Dorenda Oosterhuis, Klaas Poelstra, Harry van Goor, Peter Olinga, Jan-Luuk Hillebrands

Disease Models and Mechanisms (The Company of Biologists) The Netherlands , 24 June 2015

Nephrology

Key words: Drug targeting, Fibrosis, Kidney, Tissue slices

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Fibrosis

2817
Lanreotide-conjugated PEG-DSPE micelles: an efficient nanocarrier targeting to somatostatin receptor positive tumors

Nan Zheng, Wenbing Dai, Hua Zhang, Xueqing Wang, Jiancheng Wang, Xuan Zhang, Kun Wang, Jian Lia, Qiang Zhang

Journal of Drug Targeting (Taylor and Francis) China , 24 June 2015

Oncology

Key words: Lanreotide, over-express somatostatin receptor 2, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (poly-(ethylene glycol))-2000]

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2818
Memantine attenuates delayed vasospasm after experimental subarachnoid hemorrhage via modulating endothelial nitric oxide synthase

CY Huang, LC Wang, YS Shan, CH Pan, KJ Tsai

International Journal of Molecular Sciences (MDPI) Taiwan , 23 June 2015

Neuroscience

Key words: memantine, nitric oxide synthase, subarachnoid hemorrhage, vasospasm

Organism: Rat

Tissue: Brain

Pathological State: Vasospasm

2819
STAT3 regulated ARF expression suppresses prostate cancer metastasis

Jan Pencik, Michaela Schlederer, Wolfgang Gruber, Christine Unger, Steven M Walker, Athena Chalaris, Isabelle J Marié, Melanie R Hassler, Tahereh Javaheri, Osman Aksoy, Jaine K Blayney, Nicole Prutsch, Anna Skucha, Merima Herac, Oliver H Krämer, Peter Mazal, Florian Grebien, Gerda Egger, Valeria Poli, Wolfgang Mikulits et al

Nature Communications (Nature) Austria, UK, Germany, USA, Italy, Sweden , 22 June 2015

Oncology

Key words: STAT3 and p14ARF expression, PI3K–AKT–mTOR signalling pathway, ARF–Mdm2–p53 tumour suppressor axis

Organism: Mouse

Tissue: Xenograft Tumor, Colon

Pathological State: Cancer

2820
The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia

Stephanie M Rangel, Maureen H Diaz, Claire A Knoten, Angelica Zhang, Alan R Hauser

PLoS Pathogens (PLOS) USA , 19 June 2015

Pulmonology

Key words: Pneumocytes, pneumonia, bacterial pathogens, pseudomonas aeruginosa, pulmonary imaging, cell staining, phagocytes, blood

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

Results 2811 - 2820 of 3451

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