Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2751 - 2760 of 3451
2751
MiR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis

Varun Nagpal, Rahul Rai, Aaron T Place, Sheila B Murphy, Suresh K Verma, Asish K Ghosh, and Douglas E Vaughan

Circulation (AHA Journals) USA , 19 November 2015

Cardiology

Key words: RNA sequence, fibrosis, angiotensin II, transforming growth factor, miR-125b

Organism: Mouse

Tissue: Heart

Pathological State: Cardiac Fibrosis

2752
IMPS-11 Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Seunggu Han, Gerald Reis, Gary Kohanbash, Shruti Srivastav, Stephen Magill, Annette Molinaro, Michael McDermott, Philip Theodosopoulos, Manish Aghi, Mitchel Berger, Igor Barani, Joanna Phillips, Arie Perry, Hideho Okada

Neuro-Oncology (Oxford University Press) USA , 09 November 2015

Oncology

Key words: meningioma, patient prognosis, impact, molecule, programmed cell death 1 ligand 1

Organism: Human

Tissue: Brain

Pathological State: Cancer

2753
CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow

A Nakamura-Ishizu, K Takubo, H Kobayashi, K Suzuki-Inoue, T Suda

Journal of Experimental Medicine (Rockefeller University Press) Japan , 09 November 2015

Stem Cell Research

Key words: CLEC-2, megakaryocyte, hematopoietic stem cells, bone marrow

Organism: Mouse

Tissue: Bone Marrow

2754
Transdermal drug targeting and functional imaging of tumor blood vessels in the mouse auricle

H Schröder, D Komljenovic, M Hecker, T Korff

The FASEB Journal (FASEB) Germany , 06 November 2015

Oncology

Key words: angiogenesis • blood vessel growth • bortezomib • mouse model • perfusion

Organism: Mouse

Pathological State: Cancer

2755
Melanin pigmentation in rat eyes: in vivo imaging by polarization-sensitive optical coherence tomography and comparison to histology

Bernhard Baumann, Johannes Schirmer, Sabine Rauscher, Stanislava Fialová, Martin Glösmann, Marco Augustin, Michael Pircher, Marion Gröger, Christoph K Hitzenberger

Investigative Ophthalmology & Visual Science (ARVO Journals) Austria , 01 November 2015

Ophthalmology

Key words: Melanin Pigmentation, Eyes, In Vivo Imaging, Polarization-Sensitive Optical Coherence Tomography

Organism: Rat

Tissue: Eye

2756
Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-a Production in Women

Morgane Griesbeck, Susanne Ziegler, Sophie Laffont, Nikaïa Smith, Lise Chauveau, Phillip Tomezsko, Armon Sharei, Georgio Kourjian, Filippos Porichis, Meghan Hart, Christine D Palmer, Michael Sirignano, Claudia Beisel, Heike Hildebrandt, Claire Cénac, Alexandra-Chloé Villani, Thomas J Diefenbach, Sylvie Le Gall, Olivier Schwartz, Jean-Philippe Herbeuval, Brigitte Autran, Jean-Charles Guéry, J Judy Chang, and Marcus Altfeld

The Journal of Immunology (American Association of Immunologists) France, Germany, UK, Australia , 30 October 2015

Immunology

Key words: Plasmacytoid dendridic cell levels, IRF5

Organism: Human, Mouse

Cell Line: PBMCs (Peripheral blood mononuclear cells )

2757
Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury

Shao-Ming Wang, Jung-Yu C Hsu, Chiung-Yuan Ko, Nai-En Chiu, Wai-Ming Kan, Ming-Derg Lai, Ju-Ming Wang

Molecular Neurobiology (Springer) Taiwan , 28 October 2015

Neuroscience

Key words: Astrogliosis C/EBPd, MMP-3 RhoA, astrocyte migration

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

2758
Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy

Nastasia Wilfinger, Shane Austin, Barbara Scheiber-Mojdehkar, Walter Berger, Siegfried Reipert, Monika Praschberger, Jakob Paur, Robert Trondl, Bernhard K Keppler, Christoph C Zielinski, and Karin Nowikovsky

Oncotarget (Impact Journals) Austria , 26 October 2015

Oncology

Key words: cancer, p53, BNIP3L, mitophagy, gallium complex

Organism: Human

Pathological State: Cancer

Cell Line: Human colon carcinoma cells

2759
Quantitative Image Analysis of Epithelial and Stromal Area in Histological Sections of Colorectal Cancer: An Emerging Diagnostic Tool.

R Rogojanu, T Thalhammer, U Thiem, A Heindl, I Mesteri, A Seewald, W Jäger, C Smochina, I Ellinger, G Bises

Biomed Research International (Hindawi Publishing Corporation) Austria, Romania , 22 October 2015

Oncology

Key words: Image analysis, histology, colorectal cancer, diagnosis tool

Organism: Human

Tissue: Colon

Pathological State: Cancer

2760
Glucose-regulated protein 94 mediates cancer progression via AKT and eNOS in hepatocellular carcinoma

Chien-Yu Huang, Uyanga Batzorig, Wan-Li Cheng, Ming-Te Huang, Wei- Yu Chen, Po-Li Wei, Yu-Jia Chang

Tumor Biology (Springer) Taiwan, Mongolia , 22 October 2015

Oncology

Key words: GRP94 HCC eNOS AKT Proliferation

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

Results 2751 - 2760 of 3451

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