Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2651 - 2660 of 3451
2651
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine

Norihiro Kishida, Sachiko Matsuda, Osamu ItanoEmail author, Masahiro Shinoda, Minoru Kitago,Hiroshi Yagi, Yuta Abe, Taizo Hibi, Yohei Masugi, Koichi Aiura, Michiie Sakamoto and Yuko Kitagawa

BMC Gastroenterology (BioMed Central) Japan , 13 June 2016

Oncology

Key words: Nonalcoholic steatohepatitis, hepatocellular carcinoma, diethylnitrosamine, high-fat choline-deficient diet, mouse model

Organism: Mouse

Tissue: Liver

Pathological State: Hepatic Steatosis, Cancer, Liver Fibrosis

2652
Automated muscle fiber type population analysis with ImageJ of whole rat muscles using rapid myosin heavy chain immunohistochemistry

Konstantin D Bergmeister, Marion Gröger, Martin Aman, Anna Willensdorfer, Krisztina Manzano-Szalai, Stefan Salminger and Oskar C Aszmann

Muscle and Nerve (Wiley) Austria , 13 June 2016

Medical Image Analysis

Key words: Automated muscle fiber analysis, fiber population, ImageJ, muscle fiber type, myosin heavy chain, rat

Organism: Rat

Tissue: Muscle

2653
Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

Pu-Hyeon Cha, Yong-Hee Cho, Sang-Kyu Lee, JaeHeon Lee, Woo-Jeong Jeong, Byoung-San Moon, Ji-Hye Yun, Jee Sun Yang, Sooho Choi, Juyong Yoon, Hyun-Yi Kim, Mi-Yeon Kim, Saluja Kaduwal, Weontae Lee, Do Sik Min, Hoguen Kim, Gyoonhee Han and Kang-Yell Choi

Nature Chemical Biology (Nature) South Korea , 13 June 2016

Oncology

Key words: Cancer therapy, cell signalling, screening, small molecules

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2654
Clonorchis sinensis omega-class glutathione transferases play major roles in the protection of the reproductive system during maturation and the response to oxidative stress

Jeong-Geun Kim, Chun-Seob Ahn, Seon-Hee Kim, Young-An Bae, Na-Young Kwon, Insug Kang, Hyun-Jong Yang, Woon-Mok Sohn, Yoon Kong

Parasites and Vectors (BioMed Central) South Korea , 13 June 2016

Parasitology

Key words: Clonorchis sinensis, glutathione transferase (GST), omega-class GST, sexual maturation, reproductive system, oxidative stress

Organism: Worm

Tissue: Whole Organism

2655
Amniotic Fluid Cells Proliferation in Normal and Down Syndrome Subjects

A Honcea, R Iulian, AG Pavel, I Ion, LE Sima

ARS Medica Tomitana (Sciendo) Romania , 11 June 2016

Reproductive Medicine

Key words: Down syndrome, Trisomy 21, amniotic fluid-derived stem cells, proliferation, cell cycle

Organism: Human

Cell Line: Amniotic fluid derived cells

2656
Epidermal desmoglein 1 expression is reduced in kidney transplant recipients compared to immunocompetent patients

Jodi L Johnson, Paul Hoover, Borko D Jovanovic, Kathleen J Green, John J Friedewald, June K Robinson

Journal of Investigative Dermatology (Elsevier) USA , 11 June 2016

Dermatology

Key words: Calcineurin inhibitor, desmoglein, E-cadherin, epidermal growth factor receptor, histone deacetylase inhibitor, immunocompetent patient, K1/10, Keratin 1 or 10, kidney transplant recipient, mycophenolate mofitil, plakoglobin, squamous cell carcinoma, ultraviolet light

Organism: Human

Tissue: Skin

Pathological State: Cancer

2657
ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model

Amy M Archer, Rana Saber, Shawn Rose, Alexander Shaffer, Alexander V Misharin, FuNien Tsai, G Kenneth Haines III, Salina Dominguez, Mesut Eren, Douglas E Vaughan, Carla M Cuda and Harris Perlman

Journal of Translational Medicine (BioMed Central) USA , 10 June 2016

Immunology

Key words: Arthritis, cholesterol, inflammation, animal models of human disease

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Atherosclerosis

2658
Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang

Molecular Cancer (Springer) Taiwan , 10 June 2016

Oncology

Key words: Histone deacetylase inhibitor, radiation, triple-negative breast cancer, autophagy

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

2659
Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation

Tobias Bergler, Bettina Jung, Felix Bourier, Louisa Kühne, Miriam C Banas, Petra Rümmele, Simone Wurm, Bernhard Banas

PLoS One (PLOS) Germany , 10 June 2016

Transplantation Medicine

Key words: Macropaghes, T-lymphocytes, calcineriurin, inhibitor, renal transplantation

Organism: Human

Tissue: Kidney

Pathological State: Organ Transplantation

2660
Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer's Disease

Cheng-Chun Wu, Cheng-Chang Lien, Wen-Hsien Hou, Po-Min Chiang,Kuen-Jer Tsai

Scientific Reports (Nature) Taiwan , 06 June 2016

Neuroscience

Key words: Dementia, neural stem cells, regeneration and repair in the nervous system, stem-cell research

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

Results 2651 - 2660 of 3451

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