Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 681 - 690 of 3451
681
Disorganized adrenocortical zonational structure in COVID-19 patients: Implications of critical illness duration

TZ Wen, WJ Fu, SQ Xiao, S Wang, TR Li, XY Chen, HY Chen, J Luo, XW Bian, XH Yao

Pathology -Research and Practice (Elsevier) China , 12 March 2024

Virology

Key words: Adrenal cortex; Areas of cortical zonations; COVID-19; Corticosteroid receptor; Structural disorganization

Organism: Human

Tissue: Liver, Kidney

Pathological State: Viral Infection

682
Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis

S Zhang, Q Chen, M Jin, J Ren, X Sun, Z Zhang, Y Luo, X Sun

Phytomedicine (Elsevier) China , 11 March 2024

Neuroscience

Key words: Notoginsenoside R1, Ischemic stroke, Microbiota-gut-brain axis, TLR4/MyD88/NF-κB signaling pathway, Neuroinflammation, Systemic inflammation

Organism: Mouse

Tissue: Brain

Pathological State: Ischemia

683
Regulation of the immune cell repertoire in psoriasis patients upon blockade of IL-17a or TNFα

J Tittes, J Brell, P Fritz, C Jonak, G Stary, JM Ressler, S Künig, W Weninger, J Stöckl

Dermatology and Therapy (Springer) Austria , 08 March 2024

Dermatology, Immunology

Key words: Psoriasis, Biologics, Immunology, T cells, Dendritic cells

Organism: Human

Tissue: Skin

Pathological State: Plaque Psoriasis

684
Cytotoxic response of tumor-infiltrating lymphocytes of head and neck cancer slice cultures under mitochondrial dysfunction

MdC Greier, A Runge, J Dudas, R Hartl, M Santer, D Dejaco, TB Steinbichler, J Federspiel, C Seifarth, M Konschake, S Sprung, S Sopper, A Randhawa, M Mayr, BG Hofauer, H Riechelmann

Frontiers in Oncology (Frontiers) Austria, USA , 07 March 2024

Oncology

Key words: cytotoxic T-cells; head and neck carcinoma; immune response; mitochondrial dysfunction; mitochondrial electron transport chain

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

685
DUX4-induced HSATII transcription causes KDM2A/B–PRC1 nuclear foci and impairs DNA damage response

T Arends, H Tsuchida, RO Adeyemi, SJ Tapscott

Journal of Cell Biology (Rockerfeller University Press) USA , 07 March 2024

Molecular Biology

Key words: Chromatin or epigenetics, Development, Disease, RNA biology

686
Precursor exhausted CD8+T cells in colorectal cancer tissues associated with patient's survival and immunotherapy responsiveness

H Huang, J Ge, Z Fang, S Wu, H Jiang, Y Lang, J Chen, W Xiao, B Xu, Y Liu, L Chen, X Zheng, J Jiang

Frontiers in Immunology (Frontiers) China , 06 March 2024

Oncology

Key words: colorectal cancer; immunotherapy; multi-color immunohistochemistry; multi-omics; precursor exhausted CD8+T cells

Organism: Human

Tissue: Colon

Pathological State: Cancer

687
Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression

L Tong, X Zheng, T Wang, W Gu, T Shen, W Yuan, S Wang, S Xing, X Liu, C Zhang, C Zhang

Journal of Cellular and Molecular Medicine (Wiley) China , 06 March 2024

Oncology

Key words: autophagy, EMC6, hepatocellular carcinoma, progression, tumorigenesis, UBA52

Organism: Human

Tissue: Liver

Pathological State: Cancer

688
Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury

JB Cao, ST Zhu, XS Huang, XY Wang, ML Wu, X Li, FL Liu, L Chen, YT Zheng, JH Wang

Virologica Sinica (Elsevier) China , 06 March 2024

Virology

Key words: SARS-CoV-2, Mast cell (MC), Bronchial epithelial cell, Inflammation, Tracheal injury

Organism: Mouse

Tissue: Trachea

Pathological State: Viral Infection

689
Oleic acid induces lipogenesis and NLRP3 inflammasome activation in organotypic mouse meibomian gland and human meibomian gland epithelial cells

R Liu, M Tu, J Xue, B Xiao, J Li, L Liang

Experimental Eye Research (Elsevier) China , 05 March 2024

Ophthalmology

Key words: Oleic acid, Meibomian gland dysfunction, Lipid, NLRP3 inflammasome, AMPK

Organism: Mouse

Tissue: Eye

Pathological State: Inflammation

690
Construction of an infectious clone for enterovirus A89 and mutagenesis analysis of viral infection and cell binding

J Yan, M Wang, X Li, J Fan, R Yu, M Kang, Y Zhang, J Xu, X Zhang, S Zhang

Microbiology Spectrum (American Society for Microbiology) China , 05 March 2024

Virology

Key words: enterovirus A89; infectious clone; reverse genetics; site mutations; subgenomic replicon

Organism: Human

Pathological State: Viral Infection

Cell Line: HEK293T

Results 681 - 690 of 3451

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