Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2881 - 2890 of 3451
2881
EVI1 promotes tumor growth via transcriptional repression of MS4A3

Gerwin Heller, Anna Rommer, Katarina Steinleitner, Julia Etzler, Hubert Hackl, Petra Heffeter, Erwin Tomasich, Martin Filipits, Birgit Steinmetz, Thais Topakian, Simone Klingenbrunner, Barbara Ziegler, Andreas Spittler, Sabine Zöchbauer-Müller, Walter Berger, Rotraud Wieser

Journal of Hematology & Oncology (Springer) Austria , 01 March 2015

Oncology

Key words: EVI1, MS4A3, Transcriptional repression, Myeloid leukemia, Tumor growth

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2882
Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma

Chieh-Wen Cheng, Jenn-Ren Hsiao, Chi-Chen Fan, Yu-Kang Lo, Chi-Yuan Tzen, Li-Wha Wu, Wei-Yu Fang, Ann-Joy Cheng, Chung-Hsing Chen, I-Shou Chang, Shih Sheng Jiang, Jang-Yang Chang, Alan Yueh-Luen Lee

Molecular Carcinogenesis (Wiley) Taiwan , 01 March 2015

Oncology

Key words: Growth differentiation factor-10, transforming growth factor-β (TGF-β) superfamily, oral squamous cell carcinoma

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

2883
Poly(lactide-co-glycolide) microspheres for MRI-monitored delivery of sorafenib in a rabbit VX2 model

Jeane Chena, Sarah B White, Kathleen R Harris, Weiguo Li, Jonathan WT Yap, Dong-Hyun Kim, Robert J Lewandowski, Lonnie D Shea, Andrew C Larson

Biomaterials (Elsevier) USA , 25 February 2015

Nanomedicine

Key words: Sorafenib, hepatocellular carcinoma, poly(lactide-co-glycolide), magnetic resonance imaging

Organism: Rabbit

Tissue: Liver, Stomach, Lung

2884
Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease

Eva N Hadaschik, Xiaoying Wei, Harald Leiss, Britta Heckmann, Birgit Niederreiter, Günter Steiner, Walter Ulrich, Alexander H Enk, Josef S Smolen, Georg H Stummvoll

Arthritis Research and Therapy (BioMed Central) Germany, China, Austria , 23 February 2015

Rheumatology

Key words: Systemic lupus erythematosus, severe interface dermatitis, arthritis, mesangioproliferative glomerulonephritis

Organism: Mouse

Tissue: Bone, Connective Tissue

Pathological State: Lupus

2885
The calcium-sensing receptor: A promising target for prevention of colorectal cancer

Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Samawansha Tennakoona, Julia Höbaus, Cedric Boudot, Romuald Mentaverri, Edward M Brown, Sabina Baumgartner-Parzer, Enikö Kállay

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (Elsevier) Austria, France, USA , 18 February 2015

Oncology

Key words: Calcium-sensing receptor, tumor suppressor, colorectal cancer, colon, calcium, calcimimetic, calcilytic

Organism: Human

Pathological State: Cancer

Cell Line: Caco2 cells, HT29 cells

2886
MRI visible drug eluting magnetic microspheres for transcatheter intra-arterial delivery to liver tumors

DH Kim, J Chen, RA Omary, AC Larson

Theranostics (NCBI) USA , 07 February 2015

Oncology, Nanomedicine

Key words: MRI, microspheres, liver tumors

Organism: Rat

Tissue: Liver

Pathological State: Cancer

2887
Tissue Microarray

Myra L Wilkerson, Stephen M Hewitt

Handbook of Practical Immunohistochemistry (Springer) USA , 05 February 2015

Biological Methods

Key words: Tissue microarray, tissue cores, population studies, virtual microscopy, data exchange, standards, validation studies, quality assurance, donor block, recipient block, multitumor, tissue microarray, progression tissue microarray, prognosis tissue microarray, normal tissue microarray, frozen tissue microarray, cell line tissue microarray, xenograft tissue microarray, cutting edge matrix assembly tissue microarray, immunohistochemistry, chromogenic in situ hybridization (CISH), fluorescent in situ hybridization (FISH), quantum dots, multiplex immunoblotting, hierarchical clustering analysis, hierarchical naïve Bayes model, random forest clustering

2888
Generation of an anti-EpCAM antibody and epigenetic regulation of EpCAM in colorectal cancer

Mei-Ying Liao, Mark Yen-Ping Kuo, Tung-Ying Lu, Yi-Ping Wang, Han-Chung Wu

International Journal of Oncology (Spandidos Publications) Taiwan , 05 February 2015

Oncology

Key words: epigenetic regulation, EpCAM, colorectal cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

2889
Extracellular matrix expansion by cardiac magnetic resonance T1 mapping- validation with myocardial biopsy

Andreas Kammerlander, Caroline Tufaro, Alina F Bachmann, Beatrice A Marzluf, Stefan Aschauer, Andreas Greiser, Diana Bonderman, Julia Mascherbauer

Journal of Cardiovascular Magnetic Resonance (Springer) Austria, Germany , 03 February 2015

Cardiology

Key words: Cardiology, angiology, imaging/radiology

Organism: Human

Tissue: Heart

Pathological State: Heart Failure

2890
The expression of thymic stromal lymphopoietin in primary tumors of breast cancer is associated with prognosis

Yu H, Yang J, Li Y, Jiao S

Chinese journal of cellular and molecular immunology (NCBI) China , 01 February 2015

Oncology

Key words: Rythymic stromal lymphopoietin, disease-free survival, Univariate LOG-RANK

Organism: Human

Tissue: Breast

Pathological State: Cancer

Results 2881 - 2890 of 3451

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