Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

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Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

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Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

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Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

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Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

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SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2831 - 2840 of 3451
2831
Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6

Hui-Wen Chiu, Shu-Wen Lin, Li-Ching Lin, Yung-Ho Hsu, Yuh-Feng Lin, Sheng-Yow Ho, Yuan-Hua Wu, Ying-Jan Wang

Cancer Letters (Elsevier) Taiwan , 04 June 2015

Oncology

Key words: Radiation, Proteasome inhibitor, Autophagy, Endoplasmic reticulum stress, Pancreatic cancer

Organism: Mouse

Tissue: Xenograft Tumor, Pancreas

Pathological State: Cancer

2832
Mast cell-macrophage dynamics in modulation of dengue virus infection in skin

Ya-Ting Chu, Shu-Wen Wan, Robert Anderson, Yee-Shin Lin

Immunology (Wiley) Taiwan, Canada , 04 June 2015

Immunology

Key words: Dengue virus, KitW-sh/W-sh mice, macrophage, mast cell

Organism: Mouse

Tissue: Skin

Pathological State: Dengue Virus Infection

2833
Silencing of LRRFIP1 reverses the epithelial–mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway

Daisuke Douchi, Hideo Ohtsuka, Kyohei Ariake, Kunihiro Masuda, Shuhei Kawasaki, Kei Kawaguchi, Koji Fukase, Masaya Oikawa, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Shinichi Egawa, Michiaki Unno

Cancer Letters (Elsevier) Japan , 03 June 2015

Oncology

Key words: LRRFIP1, EMT, Wnt/β-catenin signaling, β-catenin destruction complex, Reverse EMT

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

2834
Prognostic Significance and Determinants of the 6-Min Walk Test in Patients With Heart Failure and Preserved Ejection Fraction

Caroline Zotter-Tufaro, Julia Mascherbaue, Franz Duca, Benedikt Koell, Stefan Aschaue, Andreas A Kammerlande, Adelheid Panzenboeck, Roela Sadushi-Kolici, Christine Bangert, Daniela Laimer, Robin Ristl, Irene M Lang, Diana Bonderman

JACC: Heart Failure (Elsevier) Austria , 01 June 2015

Cardiology

Key words: cardiac catheterization, exercise test, extracellular matrix, pulmonary circulation

Organism: Human

Tissue: Heart

Pathological State: Cardiac Fibrosis

2835
Mastocytosis: the new differential diagnosis of CD30-positive neoplasms

Irina Maric, Katherine R Calvoa

Leukemia and Lymphoma (Taylor and Francis) USA , 01 June 2015

Oncology

Key words: Mastocytosis disease

2836
Clinically applicable magnetic-labeling of natural killer cells for MRI of transcatheter delivery to liver tumors: preclinical validation for clinical translation

Kangan Li, Andrew C Gordon, Linfeng Zheng, Weiguo Li, Yang Guo, Jing Sun, Guixiang Zhang, Guohong Han, Andrew C Larson, Zhuoli Zhang

Nanomedicine (Future Medicine) China, USA , 01 June 2015

Nanomedicine

Key words: Intraportal vein, heparin-protamine-ferumoxytol, HPF-labeled NK cells

Organism: Rat

Tissue: Xenograft Tumor, Liver

Pathological State: Cancer

2837
Paracrine factors of human amniotic fluid-derived mesenchymal stem cells show strong anti-fibrotic properties by inhibiting myofibroblast differentiation and collagen synthesis

MM Mia, RA Bank

Journal of Stem Cell Research and Therapy (OMICS) The Netherlands , 21 May 2015

Stem Cell Research

Key words: Fibrosis, Fibroblasts, Myofibroblasts, TGFβ1, Mesenchymal stem cells, Extracellular matrix

Organism: Human

Cell Line: Adipose tissue derived stromal cells (ADSC)

2838
Suppression of NADPH oxidase- and mitochondrion-derived superoxide by Notoginsenoside R1 protects against cerebral ischemia–reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 pathways

X Meng, M Wang, X Wang, G Sun, J Ye, H Xu, X Sun

Free Radical Research (Taylor and Francis) China , 20 May 2015

Neuroscience

Key words: Cerebral ischemia–reperfusion injury, oxidative stress, apoptosis, superoxide, NADPH oxidase

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

2839
Hypoxia-preconditioned mesenchymal stem cells attenuate bleomycin-induced pulmonary fibrosis

Ying-Wei Lan, Kong-Bung Choo, Chuan-Mu Chen, Tsai-Hsien Hung, Young-Bin Chen, Chung-Hsing Hsieh, Han-Pin Kuo, Kowit-Yu Chong

Stem Cell Research & Therapy (BMC) China, Malaysia , 20 May 2015

Stem Cell Research

Key words: Bleomycin, diopathic pulmonary fibrosis, hypoxia-inducible factor, hepatocyte growth factor, connective tissue growth factor

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

2840
Texture analysis of 125I-A5B7 anti-CEA antibody SPECT differentiates metastatic colorectal cancer model phenotypes and anti-vascular therapy response

V Rajkumar, V Goh, M Siddique, M Robson, G Boxer, RB Pedley, GJR Cook

British Journal of Cancer (Wiley) UK , 19 May 2015

Oncology

Key words: Cancer models, Colorectal cancer Computed tomography Tumour heterogeneity

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

Results 2831 - 2840 of 3451

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