Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 11 - 20 of 3451
11
Myeloid ZNRF1 suppresses autoimmune demyelination and neuroinflammation by regulating MHC-II-mediated T cell activation

YC Chang, CC Wu, FT Hsiao, YS Lin, TY Lai, KH Huang, SC Tang, CY Lee, SJ Chou, LC Hsu

Journal of Neuroinflammation (Springer) Taiwan , 22 October 2025

Neuroscience

Key words: Multiple Sclerosis, Neuroinflammation, Experimental autoimmune encephalomyelitis, Macrophage, ZNRF1

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Multiple Sclerosis

12
CRISPR/Cas9 library screening reveals that STK19 has synergistic antitumor effects when combined with cisplatin on tongue squamous cell carcinoma

C Li, W Peng, Z Zhong, C Zhang, X Wang, R Qin, Q Lei, J Lv, F Liu, Y Zhao, Z Lv, C Li, S Yang, H Zhang, Z Tao, C Sun

Journal of Translational Medicine (Springer) China , 21 October 2025

Oncology

Key words: Tongue squamous cell carcinoma, CRISPR/Cas9 library, Synthetic lethality, Combinatorial drug targets, Cisplatin

Organism: Mouse

Tissue: Tongue

Pathological State: Cancer

13
Sustained‐Release Sitagliptin Microneedles for Scar Prevention via Fibroblast‐to‐Adipocyte Conversion

JL Zhang, JN Zhou, C Tang, Y Li, WD Yao, LL Guo, ZY Chen, YL Jia, Q Zeng, B Zhang, T Fan, JF Xi, XT Pei, Y Han, W Yue

Small Science (Wiley Online Library) China , 21 October 2025

Dermatology

Organism: Mouse

Tissue: Skin

Pathological State: Fibrosis

14
Enhanced FOS expression improves tumor clearance and resists exhaustion in NR4A3-deficient CAR T cells under chronic antigen exposure

P Yin, J Yang, Y Jiang, L Han, T Xiong, H Liu, Y Fang, W Ruan, J Wu, L Chen, L Tan, Y Zuo, X Wu, F Mao, R Huang, X Liu, XW Bian

Science Advances (Science) China , 17 October 2025

Oncology

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

15
Noninvasive Cell Population Profiling of Normal and Dysplastic Cervical Biofluids by Multicolor Flow Cytometry as a Promising Tool for Companion Diagnostics

C Berger, W Dietrich, M Richter, F Kellner, C Kühne, K Strasser

Cancers (MDPI) Austria, Switzerland , 15 October 2025

Pharmacology

Key words: biofluids; flow cytometry; pap smear; cervical intraepithelial lesion; cervical cancer; companion diagnostics

Organism: Human

Tissue: Cervix

16
Carcinomas exhibiting epithelial–mesenchymal transition manifest an M2 macrophage-enriched tumor immune microenvironment

HC Lien, YC Li, RYJ Huang, KC Chen, TWW Chen, IC Chen, LP Hsiao, LC Yeh, YS Lu

Breast Cancer Research (Springer) Taiwan , 14 October 2025

Oncology

Key words: Cancer Microenvironment, Epithelial-mesenchymal Transition, Peritoneal macrophages, Sarcoma, Tumour Angiogenesis, Tumour Immunology

Organism: Human

Tissue: Breast

Pathological State: Cancer

17
Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis

F Khan, E Petrosyan, Y Liu, A Bahrami, E Taefi, C Geula, MS Lesniak, P Chen

Cancer Research (AACR Journals) USA , 14 October 2025

Oncology

Organism: Human

Tissue: Breast

Pathological State: Cancer

18
MMPs and NETs are detrimental in CNS-tuberculosis with MMP Inhibition in CNS-tuberculosis mice improving survival

XY Poh, FK Loh, C Bai, HT Chong, WK Teo, YH Wong, JM Hong, QH Miow, PM Thong, B Vilaysane, TH Hu, S Chhabra, Y Wang, SC Tiong, SM Fong, M Kamihigashi, R Rajarethinam, WD Looi, ESH Cheow, GK Bonney, LS Pakkiri, CL Drum, YF Peng, M Lee, CL Tan, CSL Ding, TCC Lim, TW Yeo, JK Tay, AF Vallejo, CWM Ong

Journal of Neuroinflammation (Springer) Singapore , 11 October 2025

Neuroscience

Organism: Mouse

Tissue: Brain

Pathological State: Tuberculosis

19
Antibacterial effects of coniferyl alcohol-derived dehydrogenation polymer on chlamydial infection in vitro

A Pfundner, T Weinmayer, N Geissler, A Kovacevic, D Spaspjevic, K Radotic, M Stojanovic, I Schabussova, U Wiedermann, A Inic-Kanada

Frontiers in Chemistry (Frontiers) Austria, Serbia , 10 October 2025

Bacteriology

Key words: chlamydial infection, sexually transmitted infection, Chlamydia trachomatis, treatment, lignin, dehydrogenation polymer

Organism: Human

Pathological State: Bacterial Infection

Cell Line: A2EN

20
TIM-3 expression in tumor and stromal cells are associated with the prognosis in patients with epithelial ovarian cancer

J Wu, Y Zhang, H Zhang, Y Li, Z Jie, S Kang

Medicine (Wolters Kluwer) China , 10 October 2025

Oncology

Key words: epithelial ovarian cancer; prognosis; TIM-3; tumor cells; tumor microenvironment

Organism: Human

Tissue: Ovary

Pathological State: Cancer

Results 11 - 20 of 3451

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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