Spatial Multi-Omics Identifies NAD-Driven Niche in Early Gastric Cancer
A new study reveals how an NAD-dependent immunosuppressive niche drives early gastric cancer development. Using spatial multi-omics and TissueFAXS Spectra with StrataQuest, researchers mapped cell interactions and quantified tumor-promoting fibroblast and epithelial populations.
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Spatial Multi-Omics Identifies NAD-Driven Niche in Early Gastric Cancer
11 Mar, 2026
Highlight of the week: Spatiotemporal multi-omics analysis uncovers NAD-dependent immunosuppressive niche triggering early gastric cancer
The research team reports in Nature Signal Transduction and Targeted Therapy novel discoveries on the development of early gastric cancer. They used spatial multimodal data from patient material to construct a spatial-temporal profile of disease progression. By using spatial omics approaches, the team described an inflammatory, cancer stem cell-populated niche which orchestrates macrophage-epithelial (AREG-EGFR/ERBB2) and epithelial-fibroblast (NAMPT-ITGA5/ITGB1) crosstalk, collectively priming tumorigenic transformation.
TissueFAXS Spectra slide scanner combined with StrataQuest imaging analysis solution allowed to automatically image and quantify various fibroblastic and cancer cell populations in the tissues as well as assess the colocalisation between NAMPT+ inflammatory pit mucous cells and ITGA5+ITGB1+ fibroblasts.
Read the full study here: https://www.nature.com/articles/s41392-025-02390-w
