Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Filter publications

Customer Publications (A total of 2648 papers published)

601
PD-1+ T-Cells Correlate with Nerve Fiber Density as a Prognostic Biomarker in Patients with Resected Perihilar Cholangiocarcinoma

X Tan, J Bednarsch, M Rosin, S Appinger, D Liu, G Wiltberger, J Garcia Vallejo, SA Lang, Z Czigany, S Boroojerdi, NT Gaisa, P Boor, RD Bülow, J De Vos-Geelen, L Valkenburg-van Iersel, MC Clahsen-van Groningen, EJM de Jong, BG Koerkamp, M Doukas, FG Rocha, T Luedde, U Klinge, S Sivakumar, UP Neumann, LR Heij

Cancers (MDPI) Germany, The Netherlands, USA, UK, 27 April 2022

Oncology

Key words: cholangiocarcinoma, liver cancer, tumor microenvironment, nerve fiber density, immune checkpoint, immune cells

Organism: Human

Tissue: Bile duct

Pathological State: Cancer

602
Corallodiscus flabellata BL Burtt extract and isonuomioside A ameliorate Aβ25− 35-induced brain injury by inhibiting apoptosis, oxidative stress, and autophagy via the NMDAR2B/CamK Ⅱ/PKG pathway

M Zeng, A Feng, M Li, M Liu, P Guo, Y Zhang, Q Zhang, B Zhang, B Cao, J Jia, R Wang, J Lyu, X Zheng

Phytomedicine (Elsevier) China, 27 April 2022

Toxicology

Key words: Isonuomioside A, Corallodiscus flabellata B. L. Burtt extract, NMDAR2B, Apoptosis, Oxidative stress, Autophagy

Organism: Mouse

Tissue: Brain

603
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target

BC Moraes, HV Ribeiro-Filho, AP Roldão, EF Toniolo, GPB Carretero, GG Sgro, FAH Batista, DE Berardi, VRS Oliveira, R Tomasin, FM Vieceli, DT Pramio, AB Cardoso, ACM Figueira, SC Farah, LA Devi, CS Dale, PSL de Oliveira, D Schechtman

Science Signaling (Science) Brazil, USA, 26 April 2022

Pharmacology

604
Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site

Y Jing, F Bai, L Wang, D Yang, Y Yan, Q Wang, Y Zhu, Y Yu, Z Chen

Microbiology Spectrum (ASM Journals) China, 25 April 2022

Microbiology, Neuroscience

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

605
Oxidative Stress-Induced Growth Inhibitor (OSGIN1), a Target of X-Box-Binding Protein 1, Protects Palmitic Acid-Induced Vascular Lipotoxicity through Maintaining Autophagy

CS Khoi, CQ Xiao, KY Hung, TY Lin, CK Chiang

Biomedicines (MDPI) Taiwan, 25 April 2022

Cell Biology

Key words: palmitic acid, OSGIN1, unfolded protein response, XBP1s, autophagy, eNOS, endothelial cells

Organism: Human

Tissue: Blood Vessels

Pathological State: Atherosclerosis

606
HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer

X Lu, K Fong, G Gritsina, F Wang, SC Baca, LT Brea, JE Berchuck, S Spisak, J Ross, C Morrissey, E Corey, NS Chandel, WJ Catalona, X Yang, ML Freedman, JC Zhao, J Yu

Nature Genetics (Nature) USA, 25 April 2022

Oncology

Key words: Epigenomics, Prostate cancer, Targeted therapies

Organism: Human

Tissue: Prostate

Pathological State: Cancer

607
HLA class I downregulation in progressing metastases of melanoma patients treated with ipilimumab

A Ladányi, B Hegyi, T Balatoni, G Liszkay, R Rohregger, C Waldnig, J Dudás, S Ferrone

Pathology and Oncology Research (Elsevier) Hungary, Austria, USA, 22 April 2022

Oncology

Key words: immunotherapy, melanoma, ipilimumab, HLA class I expression, longitudinal study

Organism: Human

Tissue: Skin

Pathological State: Cancer

608
Increased fatty acid metabolism attenuates cardiac resistance to β-adrenoceptor activation via mitochondrial reactive oxygen species: A potential mechanism of hypoglycemia-induced myocardial injury in diabetes

L Huang, Z Chen, R Chen, L Lin, L Ren, M Zhang, L Liu

Redox Biology (Elsevier) China, 21 April 2022

Endocrinology

Key words: Hypoglycemia, Diabetes, Lipid metabolism, β-adrenoceptor, Mitochondrial reactive oxygen species

Organism: Mouse

Tissue: Heart

609
CIRBP-OGFR axis safeguards against cardiomyocyte apoptosis and cardiotoxicity induced by

C Liu, X Cheng, J Xing, J Li, Z Li, D Jian, Y Wang, S Wang, R Li, W Zhang, D Shao, X Ma, X Chen, J Shen, C Shi, Z Gao, W Wang, T Fan, L Liu, H Tang

International Journal of Biological Sciences (Ivyspring International Publisher) China, 20 April 2022

Cardiology, Oncology

Key words: CIRBP, Cardioprotection, OGFR, Chemotherapy-induced cardiotoxicity, Cardiomyocyte apoptosis

Organism: Mouse

Tissue: Heart

610
CD19 and POU2AF1 are Potential Immune-Related Biomarkers Involved in the Emphysema of COPD: On Multiple Microarray Analysis

DW Zhang, JJ Ye, Y Sun, S Ji, JY Kang, YY Wei, GH Fei

Journal of Inflammation Research (Dovepress) China, 20 April 2022

Pulmonology

Key words: chronic obstructive pulmonary disease, emphysema, B cell, bioinformatics analysis

Organism: Human

Tissue: Lung

Pathological State: Chronic obstructive pulmonary disease

611
Endocrine-disrupting chemicals affect sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro

A Yawer, E Sychrová, J Raška, P Babica, I Sovadinová

Food and Chemical Toxicology (Elsevier) Czech Republic, 19 April 2022

Reproductive Medicine

Key words: Connexins, Endocrine-disrupting chemicals, Gap junctional intercellular communication, Reproductive toxicity, Sertoli cells, Testicular tumors

Organism: Human

Cell Line: Sertoli TM4 cells

612
Computer-assisted evaluation enhances the quantification of interstitial fibrosis in renal implantation biopsies, measures differences between frozen and paraffin sections, and predicts delayed graft function

M Pavlovic, A Oszwald, Ž Kikić, MC Nackenhorst, R Kain, N Kozakowski

Journal of Nephrology (Springer) Austria, France, 19 April 2022

Medical Image Analysis

Key words: Implantation biopsy, Interstitial fibrosis, Computer-assisted evaluation, Delayed graft function

Organism: Human

Tissue: Kidney

Pathological State: Interstitial fibrosis

613
Robust delivery of RIG‐I agonists using extracellular vesicles for anti‐cancer immunotherapy

B Peng, TM Nguyen, MK Jayasinghe, C Gao, TT Pham, LT Vu, EYM Yeo, G Yap, L Wang, BC Goh, WL Tam, D Luo, MTN Le

Journal of Extracellular Vesicles (Wiley) Singapore, 16 April 2022

Oncology

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

614
Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging

N Mori, C Inoue, H Tamura, T Nagasaka, H Ren, S Sato, Y Mori, M Miyashita, S Mugikura, K Takase

Magnetic Resonance Imaging (Elsevier) Japan, 16 April 2022

Medical Imaging

Key words: Breast cancer, Magnetic resonance imaging, Diffusion weighted imaging, Diffusion kurtosis imaging, Histology

Organism: Human

Tissue: Breast

Pathological State: Cancer

615
The significance of NAD+ metabolites and nicotinamide N-methyltransferase in chronic kidney disease

R Takahashi, T Kanda, M Komatsu, T Itoh, H Minakuchi, H Urai, T Kuroita, S Shigaki, T Tsukamoto, N Higuchi, M Ikeda, R Yamanaka, N Yoshimura, T Ono, H Yukioka, K Hasegawa, H Tokuyama, S Wakino, H Itoh

Scientific Reports (Nature) Japan, 16 April 2022

Nephrology

Key words: Medical research, Nephrology

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

616
Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway

Y Sun, Y Qian, C Chen, H Wang, X Zhou, W Zhai, L Qiu, X Zhou, H Ning, Y Zhao, C Shi, L Han, Y Qi, Y Wu, Y Gao

Journal of Experimental & Clinical Cancer Research (BMC) China, 15 April 2022

Oncology

Key words: Esophageal squamous cell carcinoma, IL-32, Extracellular vesicle, M2 macrophage polarization, Metastasis

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

617
Protective effects of konjac glucomannan on gut microbiome with antibiotic perturbation in mice

YH Mao, Y Xu, F Song, ZM Wang, YH Li, M Zhao, F He, Z Tian, Y Yang

Carbohydrate Polymers (Elsevier) China, 14 April 2022

Gastroenterology

Key words: Polysaccharides, Molecular weight, Prebiotic fiber, Protection, Dysbiosis

Organism: Mouse

Tissue: Colon

Pathological State: Dysbiosis

618
AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia

E Gonçalves-Alves, M Garcia, CJ Rodríguez-Hernández, S Gómez-González, R Ecker, M Suñol, O Muñoz-Aznar, AM Carcaboso, J Mora, C Lavarino, S Mateo-Lozano

International Journal of Molecular Sciences (MDPI) Spain, Austria, 13 April 2022

Oncology

Key words: neuroblastoma, calcium-sensing receptor, calcimimetic, cinacalcet, AC-265347, biased signaling, differentiation, cancer-testis antigens

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

619
A phase 1b study of OXIRI in pancreatic adenocarcinoma patients and its immunomodulatory effects

M Ng, S Chen, WS Ong, A Balachander, A Seet, J Yeong, N Sutiman, TKH Lim, B Lee, YA Guo, WF Leong, SS Lee, J Lam, SP Choo, AJ Skanderup, SK Biswas, D Tai, B Chowbay

International Journal of Cancer (Wiley) Singapore, 12 April 2022

Oncology

Key words: PDAC, OXIRI, metronomic oxaliplatin, chronomodulated capecitabine, UGT1A1, irinotecan

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

620
Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy

H Kong, H Zhao, T Chen, Y Song, Y Cui

Cell Death & Disease (Nature) China, 12 April 2022

Ophthalmology

Key words: Apoptosis, Cell death

Organism: Mouse

Tissue: Eye

Pathological State: Diabetes, Retinopathy

621
Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25–35-Induced Mice by Inhibiting the NLRP3 Inflammasome

P Guo, M Zeng, S Wang, B Cao, M Liu, Y Zhang, J Jia, Q Zhang, B Zhang, R Wang, X Zheng, W Feng

Molecules (MDPI) China, 12 April 2022

Neuroscience

Key words: eriodictyol, homoeriodictyol, NLRP3 inflammasome, Alzheimer's disease, Aβ25–35

Organism: Mouse

Tissue: Brain

622
Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy

MK Jayasinghe, M Pirisinu, Y Yang, B Peng, TT Pham, CY Lee, M Tan, L Tien Vu, XTT Dang, TC Pham, H Chen, AYH Leung, WC Cho, J Shi, MTN Le

Theranostics (Ivyspring International Publisher) Singapore, Hong Kong, China, 11 April 2022

Oncology

Organism: Mouse

Tissue: Spleen

Pathological State: Cancer

623
ERBB2D16 Expression in HER2 Positive Gastric Cancer Is Associated With Resistance to Trastuzumab.

S Wang, Y Zhao, Y Song, G Qiao, Y Di, J Zhao, P Sun, H Zheng, H Huang, H Huang

Frontiers in Oncology (Frontiers Media S.A.) China, 07 April 2022

Oncology

Key words: gastric cancer, ERBB2d16, epithelial-mesenchymal transition, immunosuppression, trastuzumab resistance

Organism: Human

Tissue: Stomach

Pathological State: Cancer

624
Rho kinase inhibition ameliorates vascular remodeling and blood pressure elevations in a rat model of apatinib-induced hypertension

C Li, L Ma, Q Wang, X Shao, L Guo, J Chen, W Wang, J Yu

Journal of Hypertension (Wolters Kluwer) China, 07 April 2022

Cardiology

Key words: RhoA/Rho-associated coiled-coil domain-containing protein kinase signaling pathway, apatinib, hypertension, tyrosine kinase inhibitors, vascular endothelial growth factor

625
Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis

G Zhang, Q Wang, W Tao, W Jiang, E Elinav, Y Wang, S Zhu

Nature Biomedical Engineering (Nature) China, Israel, 07 April 2022

Nanomedicine, Gastroenterology

626
Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice

C Huang, Y Wang, P Chen, QH Shan, H Wang, LF Ding, GQ Bi, JN Zhou

Communications Biology (Nature) China, 06 April 2022

Neuroscience

Key words: 3-D reconstruction, Fluorescence imaging, Light-sheet microscopy, Neural circuits, Viral tracing

Organism: Mouse

Tissue: Brain

627
Inhibition of CXXC5 function reverses obesity‐related metabolic diseases

SH Seo, E Kim, SH Lee, Y Lee, DH Han, H Go, JK Seong, KY Choi

Clinical and Translational Medicine (Wiley) South Korea, 05 April 2022

Endocrinology

Organism: Mouse

Tissue: Pancreas

Pathological State: Obesity

628
Inhibiting MNK kinases promotes macrophage immunosuppressive phenotype to limit CD8+ T cell anti-tumor immunity

TND Pham, C Spaulding, MA Shields, AE Metropulos, DN Shah, MG Khalafalla, DR Principe, DJ Bentrem, HG Munshi

JCI Insight (American Society for Clinical Investigation) USA, 05 April 2022

Immunology, Oncology

Key words: MNK kinases, tumor-associated macrophages, CD8+ T cells, immunotherapy, antiPD-1 antibody, anti-CSF-1R antibody, pancreatic cancer, thyroid cancer

Organism: Human

Tissue: Thyroid

629
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

CC Gao, M Li, W Deng, CH Ma, YS Chen, YQ Sun, T Du, QL Liu, WJ Li, B Zhang, L Sun, SM Liu, F Li, F Qi, Y Qu, X Ge, J Liu, P Wang, Y Niu, Z Liang, YL Zhao, B Huang, XZ Peng, Y Yang, C Qin, WM Tong, YG Yang

Protein & cell (Springer) China, 04 April 2022

SARS-CoV-2, Immunology

Key words: SARS-CoV-2, NRP1, inflammation, central nervous system, viral encephalitis, rhesus macaque

Organism: Rhesus Macaques

Tissue: Lung

Pathological State: COVID-19

630
KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion

X Han, C Wang, L Song, X Wang, S Tang, T Hou, C Liu, X Liang, C Qiu, Y Wang, Y Du

EBioMedicine (Elsevier) China, Sweden, 01 April 2022

Cell Biology, Neuroscience

Key words: Extracellular vesicles, Lysosomes, KIBRA, Amyloid β, Alzheimer's disease

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

631
Extracellular Vesicles Derived from SIPA1high Breast Cancer Cells Enhance Macrophage Infiltration and Cancer Metastasis through Myosin-9

L Feng, J Weng, C Yao, R Wang, N Wang, Y Zhang, Y Tanaka, L Su

Biology (MDPI) China, Japan, 31 March 2022

Oncology

Key words: breast cancer, extracellular vesicles, macrophage, myosin-9, SIPA1

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

632
Prenatal infection predisposes offspring to enhanced susceptibility to imiquimod-mediated psoriasiform dermatitis in mice

S Yu, CW Lee, YA Li, TH Chen, HS Yu

Dermatologica Sinica (Taiwanese Society for Investigative Dermatology) Taiwan, 30 March 2022

Dermatology

Key words: Bacterial infection, lipopolysaccharide, polyinosinic:polycytidylic acid, psoriasis, psoriatic arthritis, viral infection

Organism: Mouse

Tissue: Skin

Pathological State: Psoriasis

633
Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19

N Kaneko, J Boucau, HH Kuo, C Perugino, VS Mahajan, JR Farmer, H Liu, TJ Diefenbach, A Piechocka-Trocha, K Lefteri, MT Waring, KR Premo, BD Walker, JZ Li, G Gaiha, XG Yu, M Lichterfeld, RF Padera Jr, S Pillai

Clinical Immunology (Elsevier) USA, Japan, 29 March 2022

SARS-CoV-2, Immunology

Key words: COVID-19, CD8+ T cells, Cytotoxic CD4+ T cells

Organism: Human

Tissue: Lung, Lymphoid Tissue

Pathological State: COVID-19

634
FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway

Y Zhang, Y Wang, G Zhao, EJ Tanner, M Adli, D Matei

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, 29 March 2022

Oncology

Organism: Mouse

Tissue: Ovaries, Xenograft Tumor

Pathological State: Cancer

635
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration

M Zou, Q Ke, Q Nie, R Qi, X Zhu, W Liu, X Hu, Q Sun, JL Fu, X Tang, Y Liu, DWC LI, L Gong

Cell Death & Differentiation (Nature) China, 28 March 2022

Ophthalmology

Key words: Drug development, Epigenetics

Organism: Mouse

Tissue: Eye

636
Food Allergen Nitration Enhances Safety and Efficacy of Oral Immunotherapy in Food Allergy

N Samadi, L Koidl, M Salzmann, M Klems, N Komatitsch, D Schaffer, E Weidmann, A Duschi, J Horejs-Hoeck, E Untersmayr

Nutrients (MDPI) Austria, 25 March 2022

Allergy Research

Key words: oral immunotherapy, food allergy, protein nitration, modulated immune response

Organism: Mouse

Tissue: Stomach

Pathological State: Allergy

637
Effects of Magnetite Nanoparticles and Static Magnetic Field on Neural Differentiation of Pluripotent Stem Cells

AT Semeano, FA Tofoli, JC Corrêa-Velloso, AP de Jesus Santos, Á Oliveira-Giacomelli, RR Cardoso, MA Pessoa, E Lummertz da Rocha, G Ribeiro, MZR Ferrari, LV Pereira, YD Teng, DFS Petri, H Ulrich

Stem Cell Reviews and Reports (Springer) Brazil, USA, 24 March 2022

Stem Cell Research, Nanomedicine

Key words: Neural differentiation, Magnetic nanoparticles, Magnetic field, Biomagnetic effects, Embryonic stem cells, iPSCs, Dopaminergic neurons

Organism: Human

Cell Line: Induced dopaminergic neurons

638
Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells Mitigate Endoplasmic Reticulum Stress, Inflammation, and Lung Injury in Lipopolysaccharide-Treated Obese Mice

MD Chiang, CY Chang, HJ Shih, VL Le, YH Huang, CJ Huang

Antioxidants (MDPI) Taiwan, Vietnam, 23 March 2022

Endocrinology

Key words: lung injury, obesity, endoplasmic reticulum stress, exosomes, LPS

Organism: Mouse

Tissue: Lung

Pathological State: Obesity

639
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway

Y Li, H Liu, X Liu, B Xiao, M Zhang, Y Luo, M Li, J Yang

Frontiers in Oncology (Frontiers Media S.A.) China, 22 March 2022

Oncology, Pharmacology

Key words: gracillin, non-small cell lung cancer, autophagy, mTOR signaling pathway, anti-tumor

Organism: Mouse

Tissue: Heart, Liver, Kidney, Lung, Xenograft Tumor

Pathological State: Cancer

640
A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer

PH Chou, CK Luo, N Wali, WY Lin, SK Ng, CH Wang, M Zhao, SW Lin, PM Yang, PJ Liu, JJ Shie, TT Wei

Journal of Biomedical Science (BMC) Taiwan, USA, 22 March 2022

Oncology

Key words: STAT1, Colorectal cancer, Stemness, Angiogenesis, 4',5,7-trihydroxyisoflavone (THIF), BODIPY-THIF

Organism: Human

Tissue: Colon

Pathological State: Cancer

641
Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model

H Scherthan, SQ Wagner, J Grundhöfer, N Matejka, J Müller, S Müller, S Rudigkeit, M Sammer, S Schoof, M Port, J Reindl

Cancers (MDPI) Germany, 17 March 2022

Radiotherapy

Key words: 53BP1, cell death, DNA damage, epidermis, γ-H2AX, proton minibeam radiation therapy, DNA repair, skin model

Organism: Human

Cell Line: Human reconstructed epidermis (epiCS®) models

642
Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis

M Wu, X Zhang, W Zhang, YS Chiou, W Qian, X Liu, M Zhang, H Yan, S Li, T Li, X Han, P Qian, S Liu, Y Pan, PE Lobie, T Zhu

Nature communications (Nature) China, Taiwan, 16 March 2022

Oncology

Key words: Breast cancer, Cancer stem cells, Cancer therapy, Metastasis, Tumour heterogeneity

Organism: Human

Tissue: Breast, Lymphoid Tissue

Pathological State: Cancer

643
Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway

J Lv, Y Liu, S Mo, Y Zhou, F Chen, F Cheng, C Li, D Saimi, M Liu, H Zhang, K Tang, J Ma, Z Wang, Q Zhu, WM Tong, B Huang

Nature Cell Biology (Nature) China, 15 March 2022

Oncology

Key words: Glycoproteins, Mechanisms of disease, Pancreatic cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

644
Regorafenib Reverses Temozolomide-Induced CXCL12/CXCR4 Signaling and Triggers Apoptosis Mechanism in Glioblastoma

I Chiang, YC Liu, HS Liu, AAA Ali, SY Chou, TI Hsu, FT Hsu

Neurotherapeutics (Springer) Taiwan, 10 March 2022

Oncology

Key words: Glioblastoma, Temozolomide, Regorafenib, NF-κB, CXCR4/CXCL12

Organism: Mouse

Tissue: Brain, Xenograft Tumor

Pathological State: Cancer

645
hsa-miR-875-5p inhibits tumorigenesis and suppresses TGF-β signalling by targeting USF2 in gastric cancer

S Gao, Z Zhang, X Wang, Y Ma, C Li, H Liu, C Jing, L Li, X Guo

Journal of Translational Medicine (Springer) China, 07 March 2022

Oncology

Key words: miR-875-5p, USF2, Gastric cancer, TGF-β

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

646
Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy

W Jiang, W Dong, M Li, Z Guo, Q Wang, Y Liu, Y Bi, H Zhou, Y Wang

ACS NANO (ACS Publications) China, 03 March 2022

Oncology

Key words: Nitric oxide, Immunogenic cell death, NO nanogenerator, Vaccination effects, PD-1 blockade therapy

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

647
Low miR-10b-3p associated with sorafenib resistance in hepatocellular carcinoma

YY Shao, PS Chen, LI Lin, BS Lee, A Ling, AL Cheng, C Hsu, DL Ou

British Journal of Cancer (Nature) Taiwan, USA, 02 March 2022

Oncology

Key words: Hepatocellular carcinoma, Tumour biomarkers

Organism: Mouse

Tissue: Liver, Xenograft Tumor

Pathological State: Cancer

648
Gα13 loss in Kras/Tp53 mouse model of pancreatic tumorigenesis promotes tumors susceptible to rapamycin

MA Shields, C Spaulding, AE Metropulos, MG Khalafalla, TND Pham, HG Munshi

Cell Reports (Cell Press) USA, 01 March 2022

Oncology

Key words: Gα13, KC mouse model, KPC mouse model, Human PDAC tumors, E-cadherin, mTOR, Rapamycin

Organism: Mouse

Tissue: Pancreas

Pathological State: Cancer

649
Immunoarchitectural patterns as potential prognostic factors for invasive ductal breast cancer

X Du, Z Zhou, Y Shao, K Qian, Y Wu, J Zhang, M Cui, J Wang, S Wang, Y Tai

npj Breast Cancer (Nature) China, 28 February 2022

Oncology

Key words: Breast cancer, Prognostic markers

Organism: Human

Tissue: Breast

Pathological State: Cancer

650
EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma

J Ingruber, J Dudás, D Savic, G Schweigl, TB Steinbichler, M do Carmo Greier, M Santer, S Carollo, Z Trajanoski, H Riechelmann

Experimental Cell Research (Elsevier) Austria, 25 February 2022

Oncology

Key words: Mesenchymal-to-epithelial transition, Cell-transfection, TissueFax, UPCI-SCC090, SCC25, FaDu

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

651
Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus

JH Lee, C Ostalecki, T Oberstein, S Schierer, E Zinser, M Eberhardt, K Blume, B Plosnita, L Stich, H Bruns, R Coras, J Vera-Gonzales, M Maler, AS Baur

EBioMedicine (Elsevier) Germany, Austria, 25 February 2022

Neuroscience

Key words: Alzheimer's disease, Plasma extracellular vesicles, Choroid plexus, Hippocampus, Hyaluronan, Hyaluronic acid synthetase, Secretases, BACE, Aβ, APP

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

652
Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms

X Guo, X Jin, K Han, S Kang, S Tian, X Lv, M Feng, H Zheng, Y Zuo, G Xu, M Hu, J Xu, P Lv, YZ Chang

Free Radical Biology and Medicine (Elsevier) China, 24 February 2022

Neuroscience

Key words: Iron, Ischemic stroke, Gliosis, Synaptic plasticity, Myelination, Nerve regeneration

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

653
Tumor Necrosis Factor-α Mediates Lung Injury in the Early Phase of Endotoxemia

KY Chen, CY Chang, HJ Hsu, HJ Shih, IT Huang, HH Patel, CJ Huang

Pharmaceuticals (MDPI) Taiwan, Australia, 24 February 2022

Pulmonology

Key words: lung injury, endotoxin, cytokines, cytokine receptors, peptide, mice

Organism: Mouse

Tissue: Lung

Pathological State: Endotoxemia

654
Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation

J Gao, H Mei, J Sun, H Li, Y Huang, Y Tang, L Duan, D Liu, Y Pang, Q Wang, Y Gao, K Song, J Zhao, C Zhang, J Liu

Advanced Biology (Wiley) China, Australia, 23 February 2022

SARS-CoV-2, Osteology

Organism: Human

Pathological State: Covid-19

Cell Line: Bone marrow cells

655
High farnesoid X receptor expression predicts favorable clinical outcomes in PD‑L1low/negative non‑small cell lung cancer patients receiving anti‑PD‑1‑based chemo‑immunotherapy

L Wang, X Xu, B Shang, J Sun, B Liang, X Wang, W You, S Jiang

International Journal of Oncology (Spandidos Publications) China, 23 February 2022

Oncology

Key words: Farnesoid X receptor, Predictor, anti‑PD‑1‑based, Chemo‑immunotherapy, Non‑small cell lung cancer, PD‑L1low/negative patients

Organism: Human

Tissue: Lung

Pathological State: Cancer

656
Prompt Antiviral Action of Pulmonary CD8+ TRM Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung

L Jiang, L Liu, M Zhang, L Zhang, C Zhu, Q He, L Ye, C Zhao, Z Li, J Xu, X Zhang

Frontiers in Immunology (Frontiers Media S.A.) China, 22 February 2022

Immunology

Key words: influenza, lung-resident memory CD8 T cells, IFN-γ, interferon-induced genes, inflammatory cytokines

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection

657
Meloxicam Inhibits Hepatocellular Carcinoma Progression and Enhances the Sensitivity of Immunotherapy via the MicroRNA-200/PD-L1 Pathway

S Guangshun, S Guoqiang, C Xin, K Xiangyi, Z Wubin, L Zhitao, Z Zhiying, C Hongyong, L Chengyu, X Yongxiang, T Weiwei

Journal of Oncology (Hindawi Publishing Corporation) China, 21 February 2022

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

658
TSPAN6 is a suppressor of Ras-driven cancer

PO Humbert, TZ Pryjda, B Pranjic, A Farrell, K Fujikura, R de Matos Simoes, R Karim, I Kozieradzki, SJF Cronin, GG Neely, TF Meyer, A Hagelkruys, HE Richardson, JM Penninger

Oncogene (Nature) Australia, Austria, Germany, Canada, 19 February 2022

Oncology

Key words: Cancer genetic, Cell polarity, Growth factor signalling

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

659
Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects

YH Chan, KN Ho, YC Lee, MJ Chou, WZ Lew, HM Huang, PC Lai, SW Feng

Stem Cell Research & Therapy (Springer) Taiwan, USA, 19 February 2022

Osteology

Key words: Melatonin, Dental pulp mesenchymal stem cells, Osteogenesis, COX2/NF-κB, p38/ERK signaling pathwaym, Bone regeneration, Calvarial bone defect

Organism: Rabbit

Tissue: Bone

660
The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

F Niu, P Han, J Zhang, Y She, L Yang, J Yu, M Zhuang, K Tang, Y Shi, B Yang, C Liu, B Peng, SJ Ji

Elife (eLife Sciences Publications) China, 18 February 2022

Neuroscience

Organism: Mouse

Tissue: Brain

661
Imaging net retrograde axonal transport in vivo: a physiological biomarker

PTJ Lee, Z Kennedy, Y Wang, Y Lu, C Cefaliello, Ö Uyan, CQ Song, BM da Cruz Godinho, Z Xu, M Rusckowski, W Xue, RH Brown

Annals of Neurology (Wiley) USA, 17 February 2022

Medical Imaging

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

662
Cordycerebroside A inhibits ICAM‐1‐dependent M1 monocyte adhesion to osteoarthritis synovial fibroblasts

KT Lee, CH Su, SC Liu, BC Chen, JW Chang, CH Tsai, WC Huang, CJ Hsu, WC Chen, YC Wu, CH Tang

Journal of Food Biochemistry (Wiley) Taiwan, 15 February 2022

Rheumatology

Key words: Adhesion, Cordycerebroside A, ICAM-1, M1 macrophage, Osteoarthritis

Organism: Human, Rat

Tissue: Joint Tissue

663
Quantitative Characterization of Macrophage, Lymphocyte, and Neutrophil Subtypes Within the Foreign Body Granuloma of Human Mesh Explants by 5-Marker Multiplex Fluorescence Microscopy

U Klinge, A Dievernich, J Stegmaier

Frontiers in Medicine (Frontiers Media S.A.) Germany, 15 February 2022

Medical Image Analysis

Key words: Foreign body granuloma, Mesh, Multiplex, Fluorescence, Macrophage, Lymphocyte, Neutrophil

Organism: Human

Tissue: Surgical mesh

664
A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+ CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy

D Wang, J Fang, S Wen, Q Li, J Wang, L Yang, W Dai, H Lu, J Guo, Z Shan, W Xie, X Liu, L Wen, J Shen, A Wang, Q Chen, Z Wang

International Journal of Oral Science (Nature) China, 14 February 2022

Oncology

Key words: Cancer microenvironment, Head and neck cancer

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

665
Cell-Penetrating Botulinum Neurotoxin Type A With Improved Cellular Uptake and Therapeutic Index

X Wei, L Li, Y Wu, J Liu

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) China, 11 February 2022

Biological Methods, Neuroscience

Key words: Cell-penetrating peptides, Zinc finger proteins, Botulinum neurotoxin type A, Cellular uptake, Therapeutic index

Organism: Mouse

Tissue: Muscle

666
H2S-mediated aerobic exercise antagonizes the hippocampal inflammatory response in CUMS-depressed mice

L Ruilian, Q Honglin, X Jun, L Jianxin, B Qingyun, C Yilin, M Haifeng

Journal of Affective Disorders (Elsevier) China, 10 February 2022

Neuroscience

Key words: Chronic stress stimulated depression model, Hippocampus, Hydrogen sulfide, Inflammatory, Aerobic exercise

Organism: Mouse

Tissue: Brain

Pathological State: Depression

667
The effects of hypoxia on mitochondrial function and metabolism in gastric cancer cells

J Jiang, Y Jiang, YG Zhang, T Zhang, JH Li, DL Huang, J Hou, MY Tian, L Sun, XM Su, Y Dong, YY Ma

Translational Cancer Research (AME Publishing Company) China, 10 February 2022

Oncology

Key words: Gastric cancer, Hypoxia, Mitochondrial function, Aerobic respiration

Organism: Mouse

Pathological State: Cancer

Cell Line: Gastric cancer line MKN45

668
MYC/MAX-Activated LINC00958 Promotes Lung Adenocarcinoma by Oncogenic Transcriptional Reprogramming Through HOXA1 Activation.

T Zhang, F Su, YB Lu, XL Ling, HY Dai, TN Yang, B Zhang, D Zhao, XM Hou

Frontiers in Oncology (Frontiers Media S.A.) China, 09 February 2022

Oncology

Key words: Lung adenocarcinoma, LINC00958, MYC, MAX, Transcriptional reprogramming, HOXA1

Organism: Human

Tissue: Lung

Pathological State: Cancer

669
Colonic Leucine-Rich Repeat Kinase 2 Expression Is Increased and Associated With Disease Severity in Patients With Parkinson's Disease

PH Liao, HL Chiang, CT Shun, JF Hang, HM Chiu, MS Wu, CH Lin

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 08 February 2022

Neuroscience

Key words: Parkinson's disease, Colon biopsy, Leucine-rich repeat kinase 2, Inflammatory bowel diseases, Biomarker (BM)

Organism: Human

Tissue: Colon

Pathological State: Parkinson's disease

670
Differential localization and limited cytotoxic potential of duodenal CD8+ T cells

L Mvaya, T Khaba, AE Lakudzala, T Nkosi, N Jambo, I Kadwala, A Kankwatira, PD Patel, MA Gordon, TS Nyirenda, KC Jambo, ZM Ndhlovu

JCI Insight (American Society for Clinical Investigation) Malawi, South Africa, UK, USA, 08 February 2022

Immunology

Organism: Human

Tissue: Small Intestine

671
Assessment of Physiological Rat Kidney Ageing—Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation

A Baumgartner, S Reichelt-Wurm, W Gronwald, C Samol, JA Schröder, C Fellner, K Holler, A Steege, FJ Putz, PJ Oefner, B Banas, MC Banas

Metabolites (MDPI) Germany, 08 February 2022

Transplantation Medicine, Nephrology

Key words: Kidney, Ageing, Transplantation, Inflammation, Urinary metabolites

Organism: Rat

Tissue: Kidney

672
ATP8B1 Knockdown Activated the Choline Metabolism Pathway and Induced High-Level Intracellular REDOX Homeostasis in Lung Squamous Cell Carcinoma

X Zhang, R Zhang, P Liu, R Zhang, J Ning, Y Ye, W Yu, J Yu

Cancers (MDPI) China, 07 February 2022

Oncology

Key words: ATP8B1, LUSC, CHKA, REDOX

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

673
Multi-Factorial Nerve Guidance Conduit Engineering Improves Outcomes in Inflammation, Angiogenesis and Large Defect Nerve Repair

AJ Hibbitts, Z Kočí, S Kneafsey, A Matsiko, L Žilić, A Dervan, P Hinton, G Chen, B Cavanagh, JK Dowling, CE McCoy, CT Buckley, SJ Archibald, FJ O'Brien

Matrix Biology (Elsevier) Ireland, USA, 04 February 2022

Neuroscience

Key words: Peripheral Nerve, Biomaterials, Extracellular Matrix, Nerve Guidance Conduit, Angiogenesis, Inflammation

Organism: Rat

Tissue: Nerves

674
Effect of Helicobacter pylori-associated chronic gastritis on autonomous activity and sleep quality in mice

H Liu, W Zheng, L Zhang, T Lin, Y Tang, L Hu

Frontiers in Pharmacology (Frontiers Media S.A.) China, 04 February 2022

Microbiology, Gastroenterology

Key words: Autonomous activity, Chronic gastritis, Helicobacter pylori, Mouse behavior, Sleep quality

Organism: Mouse

Tissue: Stomach

Pathological State: Gastritis

675
Tegaserod Maleate Inhibits Breast Cancer Progression and Enhances the Sensitivity of Immunotherapy

X Li, L Wu, Z Zheng, H Liu, H Li, G Sun, G Sun, Y Cheng, H Wang, Z Li, J Shi, W Tang

Journal of Oncology (Hindawi Publishing Corporation) China, Germany, 03 February 2022

Oncology, Pharmacology

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

676
Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR Publications) USA, 02 February 2022

Oncology, Immunology

Organism: Mouse

Tissue: Xenograft Tumor, Lung

Pathological State: Cancer

677
Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues

M Tsuda, R Horio, L Wang, T Takenami, J Moriya, J Suzuka, H Sugino, Z Tanei, M Tanino, S Tanaka

Scientific Reports (Nature) Japan, 02 February 2022

Biological Methods

Key words: Assay systems, Biotechnology

Organism: Human

Tissue: Colon

Pathological State: Cancer

678
Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond

S Chen, W Li, X Zheng, P Yu, P Wang, Z Sun, Y Xu, D Jiao, X Ye, M Cai, M Shen, M Wang, Q Zhang, F Kong, Y Wang, J He, H Wei, F Shi, J Du

PNAS (United States National Academy of Sciences) China, 01 February 2022

Oncology

Key words: Tumor Tissue, Histological Magnetometry, Nitrogen-Vacancy Center, Micrometer-Resolution Magnetic Imaging, Absolute Magnetic Quantification

Organism: Human

Tissue: Lung

Pathological State: Cancer

679
PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through β-catenin dysregulation

BY Ahn, MH Jeong, JH Pyun, HJ Jeong, TA Vuong, JH Bae, S An, SW Kim, YK Kim, D Ryu, HJ Kim, H Cho, GU Bae, JS Kang

Cellular and Molecular Life Sciences (Springer) South Korea, 28 January 2022

Cardiology

Key words: PRMT7, Cardiomyopathy, Wnt, β-catenin

Organism: Rat

Pathological State: Cardiac Fibrosis

Cell Line: Neonatal rat ventricular myocyte (NRVM) cells

680
Regorafenib enhances antitumor immune efficacy of anti-PD-L1 immunotherapy on oral squamous cell carcinoma

IT Chiang, YH Lee, ZL Tan, FT Hsu, HF Tu

Biomedicine & Pharmacotherapy (Elsevier) Taiwan, 26 January 2022

Oncology, Pharmacology

Key words: Oral squamous cells carcinoma, Regorafenib, Anti-PD-L1, Antitumor-induced immunity

Organism: Mouse

Tissue: Mucosa

Pathological State: Cancer

681
Metastatic Tumor Antigen 1 Contributes to Hepatocarcinogenesis Posttranscriptionally Through Novel RNA Binding Function

YT Li, CJ Liu, JH Kao, LF Lin, HC Tu, CC Wang, PH Huang, HR Cheng, PJ Chen, DS Chen, HL Wu

Hepatology (Wiley) Taiwan, 24 January 2022

Oncology

Key words: RNA stability, Post-transcriptional control, Tumorigenic capacity, Self-renewal and anchorage-independent growth, Carcinogenesis

Organism: Human

Tissue: Liver

Pathological State: Cancer

682
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach

D Douchi, A Yamamura, J Matsuo, JW Lee, N Nuttonmanit, Y Hui, M Lim, K Suda, M Shimura, S Chen, SC Pang, K Kohu, M Kaneko, H Kiyonari, A Kaneda, H Yoshida, I Taniuchi, M Osato, H Yang, M Unno, JBY So, KG Yeoh, LSH Chuang, SC Bae, Y Ito

Cellular and Molecular Gastroenterology and Hepatology (Elsevier) Singapore, Japan, 21 January 2022

Stem Cell Research, Gastroenterology

Key words: Isthmus, Stem/Progenitor Cell, Enhanced Stem Cell Activity, Preneoplastic State, Gastric Carcinogenesis

Organism: Mouse

Tissue: Stomach

683
Inhibition of β-catenin signaling attenuates arteriovenous fistula thickening in mice by suppressing myofibroblasts

CT Liu, SC Hsu, HL Hsieh, CH Chen, CY Chen, YM Sue, TH Chen, YH Hsu, FY Lin, CM Shih, YT Shiu, PH Huang

Molecular Medicine (BMC) Taiwan, USA, 21 January 2022

Nephrology

Key words: Arteriovenous fistula (AVF), β-catenin, Hemodialysis, Myofibroblast

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney disease

684
Significant changes in macrophage and CD8 T cell densities in primary prostate tumors 2 weeks after SBRT

N Kane, T Romero, S Diaz-Perez, MB Rettig, ML Steinberg, AU Kishan, D Schaue, RE Reiter, BS Knudsen, NG Nickols

Prostate Cancer and Prostatic Diseases (Nature) USA, 20 January 2022

Oncology

Key words: Cancer therapy, Prostate cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

685
Chidamide and mitomycin C exert synergistic cytotoxic effects against bladder cancer cells in vitro and suppress tumor growth in a rat bladder cancer model

SC Wang, CY Yu, YC Wu, YC Chang, SL Chen, WW Sung

Cancer Letters (Elsevier) Taiwan, 18 January 2022

Oncology

Key words: Urothelial carcinoma, Histone, N-methyl-N-nitrosourea, Deacetylase, Axl

Organism: Rat

Tissue: Bladder

Pathological State: Cancer

686
Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro, despite Eliciting a Prolonged Antiviral Response

AM Gamage, KS Tan, WOY Chan, ZZR Lew, J Liu, CW Tan, D Rajagopalan, QXX Lin, LM Tan, PN Venkatesh, YW Ong, M Thong, RTP Lin, S Prabhakar, DY Wang, LF Wang

mBio (American Society for Microbiology) Singapore, 18 January 2022

SARS-CoV-2, Immunology

Organism: Human

Pathological State: COVID-19

Cell Line: human nasal epithelial stem/progenitor cells (hNESPCs)

687
Repair phase modeling of ischemic acute kidney injury: recovery vs. transition to chronic kidney disease

K Lee, HR Jang, J Jeon, KE Yang, JE Lee, GY Kwon, DJ Kim, W Huh

American Journal of Translational Research (e-Century Publishing Corporation) South Korea, 15 January 2022

Nephrology

Key words: Ischemic acute kidney injury, Chronic kidney disease, Ischemia-reperfusion injury, Recovery, Repair

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

688
P2RX7 in dopaminergic neurons of ventral periaqueductal gray mediates HTWP acupuncture-induced consciousness in traumatic brain injury

H Tang, S Qin, W Li, X Chen, L Ulloa, Q Zhu, B Liu, Y Gong, Y Zhao, S Wang, S Li, Y Guo, Z Xu, Y Guo

Frontiers in Cellular Neuroscience (Frontiers Media S.A.) China, USA, 13 January 2022

Neuroscience

Key words: Acupuncture, Traumatic Brain Injury, Neural Projection, Dopamine, P2RX7, Ventral Periaqueductal Gray, Hand 12 Jing-Well Points

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

689
Cottonseed protein concentrate as fishmeal alternative for largemouth bass (Micropterus salmoides) supplemented a yeast-based paraprobiotic: Effects on growth performance, gut health and microbiome

X Xie, J Wang, Y Guan, S Xing, X Liang, M Xue, J Wang, Y Chang, E Leclercq

Aquaculture (Elsevier) China, France, 13 January 2022

Zoology

Key words: Cottonseed Protein Concentrate, Largemouth Bass, Paraprobiotic, Gut Health, Gut Microbiome

Organism: Bass Fish

Tissue: Small Intestine

Pathological State: Alzheimer's Disease

690
Autochthonous Human Dirofilaria repens Infection in Austria

N Geissler, J Ruff, J Walochnik, W Ludwig, H Auer, U Wiedermann, W Geissler

Acta Parasitologica (Springer) Austria, 12 January 2022

Parasitology

Key words: Dirofilariasis · Nematode infections · Parasitic worms · Climate change · Austria

Organism: D. repens

Tissue: Whole Organism

691
Large deletion of Wdr19 in developing renal tubules disrupts primary ciliogenesis leading to polycystic kidney disease in mice

SS Yu, E Wang, CY Chiang, PH Cheng, YS Yeh, YY Wu, YY Chiou, ST Jiang

The Journal of Pathology (Wiley) Taiwan, 10 January 2022

Nephrology

Key words: Wdr19, intraflagellar transport, primary cilia, renal cyst, polycystic kidney disease

Organism: Mouse

Tissue: Kidney

Pathological State: Kidney Disease

692
Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease

HC Campos, DE Ribeiro, D Hashiguchi, DY Hukuda, C Gimenes, SAA Romariz, Q Ye, Y Tang, H Ulrich, B Monteiro Longo

Stem Cell Reviews and Reports (Springer) Brazil, China, 08 January 2022

Neuroscience, Stem Cell Research

Key words: Alzheimer's Disease, Hippocampus, Neural and Mesenchymal Stem Cell Transplantation, Tissue Cytometry, Amyloid-β plaques

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

693
Obesity attenuates inflammation, protein catabolism, dyslipidaemia, and muscle weakness during sepsis, independent of leptin

W Vankrunkelsven, S Derde, J Gunst, S Vander Perre, E Declerck, L Pauwels, I Derese, G Van den Berghe, L Langouche

Journal of Cachexia, Sarcopenia and Muscle (Wiley) Belgium, 07 January 2022

Infectious Diseases, Endocrinology

Key words: Leptin, Critical Illness, Sepsis, Muscle Weakness, Intensive Care Unit Acquired Weakness, Atrophy, Protein Catabolism

Organism: Mouse

Tissue: Muscle

Pathological State: Sepsis, Obesity

694
Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection

FJ Ogunshola, W Smidt, AF Naidoo, TP Nkosi, T Ngubane, PT Khaba, OO Baiyegunhi, B Mahlobo, S Rasehlo, N Ngema, I Jajbhay, KL Dong, V Ramsuran, J Pansegrouw, T Ndung'u, B Walker, T de Oliveria, ZM Ndhlovu

Blood Advances (ASH Publications) South Africa, USA, Germany, 06 January 2022

Immunology

Key words: Immunobiology, Immunotherapy

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

695
Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity

H Wang, Y Fan, W Chen, Z Lv, S Wu, Y Xuan, Chenfeng Wang, Yongliang Lu,Tao Guo,Donglai Shen,Fan Zhang,Qingbo Huang,Yu Gao,Hongzhao Li,Xin Ma,Baojun Wang,Yan Huang &Xu Zhang

OncoImmunology (Taylor & Francis) China, 05 January 2022

Oncology

Key words: CMTM6, DNA Damage, Cellular Senescence, Immunity, Renal Cell Carcinoma

Organism: Human

Pathological State: Cancer

Cell Line: HKC cells, ccRCC cells, HEK293T cells

696
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages

Z Wang, J Lv, P Yu, Y Qu, Y Zhou, L Zhou, Q Zhu, S Li, J Song, W Deng, R Gao, Y Liu, J Liu, WM Tong, C Qin, B Huang

Cellular & molecular Immunology (Nature) China, 04 January 2022

SARS-CoV-2, Immunology

Key words: SARS-CoV-2, Microparticles, Alveolar Macrophages, Endosomes, Lysosomes

Organism: Mouse

Tissue: Lung

Pathological State: COVID-19

697
Perichondrial progenitor cells promote proliferation and chondrogenesis of mature chondrocytes

CL Ho, LLH Huang, SJ Shieh

Regenerative Biomaterials (Chinese Society for Biomaterials) Taiwan, 04 January 2022

Stem Cell Research

Key words: Chondrocytes, Cell Proliferation, Perichondrial Progenitor Cells, Paracrine Effect, Neocartilage Formation

Organism: Mouse

Tissue: Joint Tissue

698
Stabilization but no functional influence of HIF-1α expression in the intestinal epithelium during Salmonella Typhimurium infection

L Robrahn, A Dupont, S Jumpertz, K Zhang, CH Holland, J Guillaume, S rappold, J Roth, V Cerovic, J Saez-Rodriguez, MW Hornef, T Cramer

Infection and Immunity (American Society for Microbiology) Germany, The Netherlands, 03 January 2022

Immunology, Microbiology

Organism: Mouse

Tissue: Small Intestine, Colon

Pathological State: Salmonella Typhimurium infection

699
Preclinical Safety of a 3D-Printed Hydroxyapatite-Demineralized Bone Matrix Scaffold for Spinal Fusion

M Plantz, J Lyons, JT Yamaguchi, AC Greene, DJ Ellenbogen, MJ Hallman, V Shah, C Yun, AE Jakus, D Procissi, S Minardi, RN Shah, WK Hsu, EL Hsu

Spine (ingentaconnect) USA, 01 January 2022

Osteology

Key words: 3D Printing, Bone Morphogenetic Protein-2, Demineralized Bone Matrix, Host Inflammatory Response, Hydroxyapatite, Spinal Fusion

Organism: Rat

Tissue: Bone

700
Detection of Cytopathic Effects Induced by Influenza, Parainfluenza, and Enterovirus Using Deep Convolution Neural Network

JJ Chen, PH Lin, YY Lin, KY Pu, CF Wang, SY Lin, TS Chen

Biomedicines (MDPI) Taiwan, 28 December 2021

Machine Learning, Virology

Key words: Artificial Intelligence, Cytopathic Effect, ResNet-50

701
The liquid Kangfuxin (KFX) has efficient antifungal activity and can be used in the treatment of vulvovaginal candidiasis in mouse

J Ma, YC Yang, LQ Su, DM Qin, K Yuan, Y Zhang, RR Wang

Letters in Applied Microbiology (Wiley) China, 27 December 2021

Infectious Diseases, Reproductive Medicine

Key words: Candida Albicans, Kangfuxin Liquid, Antifungal, Vaginal Candidiasis, Murine Model

Organism: Mouse

Tissue: Vagina

Pathological State: Candidiasis

702
Let-7i-5p Mediates the Therapeutic Effects of Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells on Mitigating Endotoxin-Induced Mortality and Liver Injury in High-Fat Diet-Induced Obese Mice

CY Chang, KY Chen, HJ Shih, M Chiang, IT Huang, YH Huang, CJ Huang

Pharmaceuticals (MDPI) Taiwan, 27 December 2021

Endocrinology

Key words: Obesity, Sepsis, Liver, Exosomes, let-7i

Organism: Mouse

Tissue: Liver

Pathological State: Obesity

703
Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis

J Zhang, L Wang, C Li, H Zhang, R Li, M Li

Systems biology in Reproductive Medicine (Taylor & Francis) China, 27 December 2021

Reproductive Medicine

Key words: Letrozole, Endometriosis, Endometrial Receptivity, Integrin avβ3, HOXA10

Organism: Rat

Tissue: Endometrium

Pathological State: Endometriosis

704
Vitamin D Analogs Regulate the Vitamin D System and Cell Viability in Ovarian Cancer Cells

K Piatek, A Kutner, D Cacsire Castillo-Tong, T Manhardt, N Kupper, U Nowak, M Chodyński, E Marcinkowska, E Kallay, M Schepelmann

International Journal of Molecular Sciences (MDPI) Austria, Poland, 24 December 2021

Endocrinology, Oncology

Key words: Vitamin D, Vitamin D Analogs, 25 Vitamin D 24-Hydroxylase, CYP24A1, Proliferation, High-Grade Serous Ovarian Cancer Cells

Organism: Human

Pathological State: Cancer

Cell Line: Ovarian cancer cells

705
Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression

YH Chu, WC Liao, YJ Ho, CH Huang, TJ Tseng, CH Liu

Cells (MDPI) Taiwan, 20 December 2021

Oncology

Key words: Glioma, Chondroitin Sulfate, CHSY1, Integrin Β1, CD44, Therapeutic Peptide

706
S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 MAPK Pathways

K Tanigawa, S Tsukamoto, Y Koma, Y Kitamura, S Urakami, M Shimizu, M Fujikawa, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki

The American Journal of Pathology (Elsevier) Japan, 20 December 2021

Oncology

Organism: Human

Pathological State: Cancer

Cell Line: Peripheral blood monocytes

707
Spatial point pattern analysis identifies mechanisms shaping the skin parasite landscape in Leishmania donovani infection

JSP Doehl, H Ashwin, N Brown, A Romano, S Carmichael, JW Pitchford, PM Kaye

Frontiers in Immunology (Frontiers Media S.A.) UK, 16 December 2021

Parasitology

Key words: Leishmania donovani, host cell, dispersion, dispersal, skin patches, spatial point pattern analysis

Organism: Mouse

Tissue: Skin

Pathological State: Leishmaniasis

708
P2Y12 receptor as a new target for electroacupuncture relieving comorbidity of visceral pain and depression of inflammatory bowel disease

Y Li, H Zhang, J Yang, M Zhan, X Hu, Y Liu, L Yu, X Yan, S Liang, R Zhang, Y Lu, B Li, C Liu, M Li

Chinese Medicine (Springer) China, 16 December 2021

Gastroenterology

Key words: P2Y12 Receptor, Visceral Pain, Depression, EA, IBD

Organism: Mouse

Tissue: Brain

Pathological State: Depression, Inflammatory bowel disease

709
Hedgehog-signalling in papillary fibroblasts is essential for hair follicle regeneration during wound healing

S Frech, A Forsthuber, A Korosec, K Lipp, V Kozumov, BM Lichtenberger

Journal of Investigative Dermatology (Elsevier) Austria, 16 December 2021

Dermatology

Key words: Wound Healing, Dermal Fibroblast Lineages, Hedgehog Signaling, Hair Follicle Neogenesis, WIHN, Papillary and Reticular Fibroblasts, Regeneration

Organism: Mouse

Tissue: Skin

710
Overexpression of NEK2 is correlated with poor prognosis in human clear cell renal cell carcinoma

C Wang, Y Huang, X Ma, B Wang, X Zhang

International Journal of Immunpathology and Pharmacology (SAGE Journals) China, 15 December 2021

Oncology

Key words: Clear Cell Renal Cell Carcinoma, NEK2, Prognosis

Organism: Human

Tissue: Kidney

Pathological State: Cancer

711
CD163+ M2 macrophages promote fibrosis in IgG4‐related disease via TLR7/IRAK4/NF‐κB signaling

A Chinju, M Moriyama, N Kakizoe-Ishiguro, H Chen,Y Miyahara, AR Haque, K Furusho, M Sakamoto, K Kai, K Kibe, S Hatakeyama-Furukawa, M Ito-Ohta, T Maehara, S Nakamura

Arthritis & Rheumatology (Wiley) Japan, Bangladesh, 15 December 2021

Immunology, Rheumatology

Key words: Igg4-Related Disease, M2 Macrophage, Toll-Like Receptor 7, IL-1 Receptor-Associated Kinase 4, Fibrosis

Organism: Human

Tissue: Salivary Gland

Pathological State: IgG4-Related Disease

712
Nuplazid suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting PAK4

Y Wei, W Wu, Y Jiang, H Zhou, Y Yu, L Zhao, X Wu, X Lu, Q Yuan, Z Wang, Z Dong, L He, J Zhao, K Liu

British Journal of Cancer (Nature) China, 15 December 2021

Oncology

Key words: Cancer Prevention

Organism: Mouse

Tissue: Xenograft Tumor, Esophagus

Pathological State: Cancer

713
A Single Vaccine Protects against SARS-CoV-2 and Influenza Virus in Mice

K Cao, X Wang, H Peng, L Ding, X Wang, Y Hu, L Dong, T Yang, X Hong, M Xing, D Li, C Zhu, X He, C Zhao, P Zhao, D Zhou, X Zhang, J Xu

Journal of Virology (American Society for Microbiology) China, 15 December 2021

SARS-CoV-2

Key words: COVID-19, Vaccine, SARS-CoV-2 Variants, Influenza, Adenoviral Vector

Organism: Mouse

Tissue: Lung

Pathological State: COVID-19

714
Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development

T Wang, J Zhang, N Li, M Li, S Ma, S Tan, X Guo, Z Wang, Z Wu, L Gao, C Ma, X Liang

Molecular Therapy (Cell Press) China, 15 December 2021

Oncology

Key words: Tim-3, Tim-3 Ligands, Immune Checkpoint Blockade, Tumor Microenvironment, Multiplexed Immunofluorescence

Organism: Human

Tissue: Liver

Pathological State: Cancer

715
Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response

YT Yen, M Chien, PY Wu, CC Ho, CT Ho, KCY Huang, SF Chiang, KSC Chau, WTL Chen, SC Hung

Nature Communications (Nature) Taiwan, 15 December 2021

Oncology, Immunology

Key words: Cancer Immunotherapy, Colon Cancer, Gene Silencing, Immunoediting

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

716
Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

J Chen, J Fan, Z Chen, M Zhang, H Peng, J Liu, L Ding, M Liu, C Zhao, P Zhao, S Zhang, X Zhang, J Xu

PNAS (United States National Academy of Sciences) China, 14 December 2021

SARS-CoV-2

Organism: Human

Pathological State: COVID-19

Cell Line: WT A549 cells

717
Polypharmacological reprogramming of tumor-associated macrophages towards an inflammatory phenotype

N Nishida-Aoki, TS Gujral

Cancer Research (AACR Publications) USA, 13 December 2021

Oncology

Key words: Tumor-Associated Macrophage, Breast Cancer, Tumor Microenvironment, Kinase Inhibitor Screening, Cell-Cell Interaction

Organism: Mouse

Tissue: Allograft Tumor, Lung

Pathological State: Cancer

718
The effect of local steroid application on bony fusion in a rat posterolateral spinal arthrodesis model

A Kannan, S Minardi, DJ Ellenbogen, MJ Hallman, AC Greene, JT Yamaguchi, MA Plantz, S Jeong, KC Sana, V Shah, C Yun, EL Hsu, WK Hsu

JOR Spine (Wiley) USA, 13 December 2021

Rheumatology

Key words: Local Steroid, Osteogenesis, Pseudarthrosis, Spine Fusion

Organism: Mouse

Tissue: Bone

Pathological State: Spinal arthrodesis

719
The plasminogen receptor Plg‐RKT regulates adipose function and metabolic homeostasis

F Samad, H Bai, N Baik, P Haider, Y Zhang, G Rega-Kaun, C Kaun, M Prager, J Wojta, Q Bui, S Chakrabarty, J Wang, RJ Parmer, LA Miles

Journal of Thrombosis and Haemostasis (Wiley) USA, Austria, 12 December 2021

Endocrinology

Key words: Adipose Inflammation, Hepatic Steatosis, Insulin Resistance, Obesity, Plg-RKT

Organism: Human

Tissue: Adipose Tissue

Pathological State: Obesity

720
Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension

Z Zhao, Z Guo, Z Yin, Y Qiu, B Zhou

Frontiers in Physiology (Frontiers Media S.A.) China, 10 December 2021

Gastroenterology

Key words: Intra-Abdominal Hypertension, Abdominal Compartment Syndrome, Fecal Microbiota Transplantation, 16S rRNA, Gut Microbiota Dysbiosis

Organism: Rat

Tissue: Liver

Pathological State: Liver Injury

721
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

T Zhang, L Sun, Y Hao, C Suo, S Shen, H Wei, W Ma, P Zhang, T Wang, X Gu, ST Li, Z Chen, R Yan, Y Zhang, Y Cai, R Zhou, W Jia, F Huang, P Gao, H Zhang

Nature Cancer (Nature) China, 09 December 2021

Oncology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

722
FGL1 as a Novel Mediator and Biomarker of Malignant Progression in Clear Cell Renal Cell Carcinoma.

Z Lv, B Cui, X Huang, HY Feng, T Wang, HF Wang, YD Xuan, HZ Li, X Ma, Y Huang, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 09 December 2021

Oncology

Key words: biomarker, clear cell renal cell carcinoma, epithelial to mesenchymal transition, fibrinogen-like protein 1, progression

Organism: Human

Tissue: Kidney

Pathological State: Cancer

723
CD146 as a Prognostic-Related Biomarker in ccRCC Correlating With Immune Infiltrates

Z Lv, HY Feng, W Tao, HZ Li, X Zhang

Frontiers in Oncology (Frontiers Media S.A.) China, 08 December 2021

Oncology

Key words: CD146, ccRCC, prognosis, methylation, tumor microenvironment

Organism: Human

Tissue: Kidney

Pathological State: Cancer

724
Lipid Droplet-Specific Probe for Rapidly Locating Atherosclerotic Plaques and Intraoperative Imaging via In Situ Spraying

M Sang, B Cai, S Qin, S Zhao, Y Mao, Y Wang, X Yu, J Zheng

ACS Applied Materials & Interfaces (ACS Publications) China, 06 December 2021

Biological Methods

Key words: Lipids, Liquids, Fluorescence, Fluorescence Imaging, Probes

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

725
Hedgehog signaling controls bone homeostasis by regulating osteogenic/adipogenic fate of skeletal stem/progenitor cells in mice

L Zhang, X Fu, L Ni, C Liu, Y Zheng, H You, M Li, C Xiu, L Zhang, T Gong, N Luo, Z Zhang, G He, S Hu, H Yang, D Chen, J Chen

Journal of Bone and Mineral Research (Wiley) China, 06 December 2021

Osteology, Stem Cell Research

Key words: Genetic Animal Models, Hedgehogs, Stromal/Stem Cells, Osteoporosis, Aging

Organism: Mouse

Tissue: Bone

726
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

JL Zhang, YH Li, LL Wang, HQ Liu, SY Lu, Y Liu, K Li, B Liu, SY Li, FM Shao, K Wang, N Sheng, R Li, JJ Cui, PC Sun, CX Ma, B Zhu, Z Wang, YH Wan, SS Yu, Y Che, CY Wang, C Wang, Q Zhang, LM Zhao, XZ Peng, Z Cheng, JB Chang, JD Jiang

Signal Transduction and Targeted Therapy (Nature) China, 06 December 2021

SARS-CoV-2

Key words: Drug Development, Infectious Diseases

Organism: Monkey

Tissue: Brain, Lung

Pathological State: COVID-19

727
Ascorbic acid-2 glucoside mitigates intestinal damage during pelvic radiotherapy in a rat bladder tumor model

Y Ito, T Yamamoto, K Miyai, J Take, H Scherthan, A Rommel, S Eder, K Steinestel, A Rump, M Port, N Shinomiya, M Kinoshita

International Journal of Radiation Biology (Taylor & Francis) Japan, Germany, 06 December 2021

Oncology, Radiotherapy

Key words: AY-27 Cells, DNA Damage, 53BP1, CD163, M1/M2, Macrophages

Organism: Rat

Tissue: Bladder

Pathological State: Cancer

728
Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration

M Zou, L Gong, Q Ke, R Qi, X Zhu, W Liu, Q Sun, X Tang, Z Luo, X Gong, Y Liu, DWC Li

Free Radical Biology and Medicine (Elsevier) China, 04 December 2021

Cell Biology

Key words: Age-Related Macular Degeneration, Heterochromatin, Inflammation, Methotrexate, cGAS, STING

Organism: Mouse

Tissue: Eye

Pathological State: Macular degeneration

729
Defect of LSS Disrupts Lens Development in Cataractogenesis.

M Zhao, T Mei, B Shang, B Zou, Q Lian, W Xu, K Wu, Y Lai, C Liu, L Wei, J Zhu, K Zhang, Y Liu, L Zhao

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 02 December 2021

Developmental Biology

Key words: lanosterol synthase, congenital cataract, mouse model, mutation, lens development

Organism: Mouse

Tissue: Eye

Pathological State: Cataract

730
Mad2 Induced Aneuploidy Contributes to Eml4-Alk Driven Lung Cancer by Generating an Immunosuppressive Environment

K Alikhanyan, Y Chen, K Somogyi, S Kraut, R Sotillo

Cancers (MDPI) Germany, 30 November 2021

Oncology

Key words: Lung Cancer, Aneuploidy, Tumor Microenvironment, Immune Suppression, Mouse Models

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

731
Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1

A Lo, K Holmes, S Kamlapurkar, F Mundt, S Moorthi, I Fung, S Fereshetian, J Watson, SA Carr, P Mertins, AH Berger

Science Signaling (Science) USA, 30 November 2021

Oncology

Organism: Human

Cell Line: AALE cells

732
Conjugation to PEG as a Strategy to Limit the Uptake of Drugs by the Placenta: Potential Applications for Drug Administration in Pregnancy

A Dodd, AA Natfji, A Evangelinos, A Grigoletto, G Pasut, F Beards, L Renshall, HMI Osborn, F Greco, LK Harris

Molecular Pharmaceutics (ACS Publications) UK, Italy, 29 November 2021

Pharmacology

Key words: Polymer−Drug Conjugate PEG Pregnancy Placenta Transport Drug Delivery

Organism: Human

Tissue: Placenta

Pathological State: Pregnancy

733
ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

VA Arrieta, AX Chen, JR Kane, SJ Kang, C Kassab, C Dmello, J Zhao, KB Burdett, PS Upadhyayula, C Lee-Chang, J Shilati, D Jaishankar, L Chen, A Gould, D Zhang, J Yuan, W Zhao, X Ling, JK Burks, B Laffleur, C Amidei, JN Bruce, RV Lukas, JT Yamaguchi, D Cieremans, G Rothschild, U Basu, M McCord, DJ Brat, H Zhang, LAD Cooper, B Zhang, P Sims, TF Cloughesy, R Prins, P Canoll, R Stupp, AB Heimberger, C Horbinski, FM Iwamoto, R Rabadan, AM Sonabend

Nature Cancer (Nature) USA, Mexico, France, 29 November 2021

Oncology

Key words: Cancer, Cancer Immunotherapy, CNS Cancer, Tumour Biomarkers

Organism: Human

Tissue: Brain

Pathological State: Cancer

734
Single cell imaging-based chromatin biomarkers for tumor progression

S Venkatachalapathy, DS Jokhun, M Andhari, GV Shivashankar

Scientific Reports (Nature) Singapore, India, Italy, Switzerland, 29 November 2021

Oncology

Key words: Biomarkers, Biophysics, Cancer, Computational Biology and Bioinformatics

Organism: Human

Tissue: Breast

Pathological State: Cancer

735
Lipid‐Activatable Fluorescent Probe for Intraoperative Imaging of Atherosclerotic Plaque Using In Situ Patch

J Zheng, S Zhao, Y Mao, Z Du, G Li, M Sang

Nano Micro Small (Wiley) China, 27 November 2021

Biological Methods

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerosis

736
HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

C Da, J Pu, Z Liu, J Wei, Y Qu, Y Wu, B Shi, J Yang, N He, P Hou

Signal Transduction and Targeted Therapy (Nature) China, 24 November 2021

Oncology

Key words: Cancer, Molecular Biology

Organism: Human

Tissue: Brain

Pathological State: Cancer

737
Mechanism of Chronic Stress-Induced Glutamatergic Neuronal Damage in the Basolateral Amygdaloid Nucleus

S Wang, X Liu, W Shi, Q Qi, G Zhang, Y Li, B Cong, M Zuo

Analytical Cellular Pathology (Hindawi Publishing Corporation) China, 23 November 2021

Neuroscience

Organism: Rat

Tissue: Brain

738
Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

C Wang, A Cui, M Bukenya, A Aung, D Pradhan, CA Whittaker, Y Agarwal, A Thomas, S Liang, P Amlashi, H Suh, S Spranger, N Hacohen, DJ Irvine

Cell Reports (Cell Press) USA, 23 November 2021

Immunology, Oncology

Key words: NK Cell, Macrophage, Checkpoint Blockade, Sensitization, Tumor-Targeting Antibody, Interleukin-2, Tumor Microenvironment, Vascular Normalization

Organism: Mouse

Tissue: Allograft Tumor, Skin

Pathological State: Cancer

739
Pectins from various sources inhibit galectin-3-related cardiac fibrosis

AR van der Velde, WC Meijers, HHW Silljé, P Muntendam, MM Dokter, WH van Gilst, HA Schols, RA de Boer

Current Research in Translational Medicine (Elsevier) USA, The Netherlands, 23 November 2021

Cardiology

Key words: Galectin-3, Inhibitor, Pectin, Heart failure, Fibrosis, Affinity

Organism: Human

Cell Line: Monocytes

740
CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c. 1085 Genotypes

YM Yeh, PC Lin, WC Su, MR Shen

International Journal of Molecular Sciences (MDPI) Taiwan, 22 November 2021

Oncology

Key words: Colony-Stimulating Factor 1 Receptor, Genetic Variant, CD40, IL-2 Expression, Colorectal Cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

741
Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds

WH Tsai, CH Chou, TY Huang, HL Wang, PJ Chien, WW Chang, HT Lee

Cells (MDPI) Taiwan, 22 November 2021

Dermatology

Key words: Heat-Killed Probiotics, Lactobacillus, L. Plantarum, L. Paracasei, Skin Wound Healing, Lipoteichoic Acid

Organism: Mouse

Tissue: Skin

Pathological State: Cutaneous Wound

742
Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin-and mucosa-resident memory T cells

S Saluzzo, RV Pandey, LM Gail, R Dingelmaier-Hovorka, L Kleissl, L Shaw, B Reininger, D Atzmüller, J Strobl, V Tonzeau-Römer, A Beer, C Staud, A Rieger, M Farlik, W Weninger, G Stingl, G Stary

Immunity (Cell Press) Austria, 22 November 2021

Immunology, Virology

Key words: HIV, Tissue-Resident Memory T Cells, Skin, Mucosal Immunity, HPV, Cancer, CXCR3

Organism: Human

Tissue: Skin

Pathological State: HIV Infection

743
BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression

Q Wu, F Liu, M Ge, KV Laster, L Wei, R Du, M Jiang, J Zhang, Y Zhi, G Jin, S Zhao, DJ Kim, Z Dong, K Liu

Oncogene (Nature) China, 19 November 2021

Oncology

Key words: Oncogenes, Transcription

Organism: Human

Cell Line: KYSE450 cells

744
Calenduloside E protects against myocardial ischemia-reperfusion injury induced calcium overload by enhancing autophagy and inhibiting L-type Ca2+ …

R Wang, M Wang, B Liu, H Xu, J Ye, X Sun, G Sun

Biomedicine & Pharmacotherapy (Elsevier) China, 17 November 2021

Cardiology

Key words: calenduloside E, myocardial ischemia-reperfusion injury, L-type Ca2+ channels, BAG3, calcium overload, autophagy

Organism: Rat

Tissue: Heart

Pathological State: Myocardial ischemia

745
Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy

M Gao, Y Chen, C Wu

Bioengineered (Taylor & Francis) China, 16 November 2021

Nanomedicine, Oncology

Key words: Malignant Glioma, Doxorubicin-Loaded Nanoparticles, Chemosensitization, Tumor Chemotherapy, Size-Dependent

Organism: Mouse

Tissue: Heart, Kidney, Liver, Lung, Spleen

Pathological State: Cancer

746
HSBP1 Is a Novel Interactor of FIP200 and ATG13 That Promotes Autophagy Initiation and Picornavirus Replication

M Mauthe, N Dinesh Kumar, P Verlhac, N van de Beek, F Reggiori

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) The Netherlands, 15 November 2021

Virology

Key words: Autophagy, Infection, ULK Kinase Complex, EMCV, CVB3, EV71

Organism: Human

Cell Line: U2OS cells 

747
Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells

KC Wei, YC Lin, CH Chen, YH Chu, CY Huang, WC Liao, CH Liu

American Journal of Cancer Research (e-Century Publishing Corporation) Taiwan, 15 November 2021

Oncology

Key words: Fucosyltransferase 8, Glioma, HGF, MET, EGFR

Organism: Human

Tissue: Brain

Pathological State: Cancer

748
Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

LC Wang, WY Wei, PC Ho, PY Wu, YP Chu, KJ Tsai

Frontiers in Aging Neuroscience (Frontiers Media S.A.) Taiwan, 12 November 2021

Neuroscience

Key words: Cortical Electrical Stimulation, Neuromodulation, Ischemic Stroke, BDNF, PI3K – PKB/Akt Signaling Pathway

Organism: Rat

Tissue: Brain

Pathological State: Cerebral Ischemia

749
TJP1 Contributes to Tumor Progression through Supporting Cell-Cell Aggregation and Communicating with Tumor Microenvironment in Leiomyosarcoma

EY Lee, M Kim, BK Choi, DH Kim, I Choi, HJ You

Molecules and Cells (Korean Society for Molecular and Cellular Biology) South Korea, 12 November 2021

Oncology

Key words: cytokines, leiomyosarcoma, tjp1, tumor microenvironment

Organism: Mouse

Tissue: Xenograft Tumor, Esophagus

Pathological State: Cancer

750
Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

AE Hinman, C Jani, SC Pringle, WR Zhang, N Jain, AJ Martinot, AK Barczak

eLife (eLife Sciences Publications) USA, 10 November 2021

Immunology, Microbiology

Organism: Mouse

Tissue: Lung

Pathological State: Tuberculosis

751
Dopamine D2 receptor regulates cortical synaptic pruning in rodents

YQ Zhang, WP Lin, LP Huang, B Zhao, CC Zhang, DM Yin

Nature Communications (Nature) China, 08 November 2021

Neuroscience

Key words: Diseases of The Nervous System, Molecular Neuroscience, Spine Regulation and Structure, Synaptic Development

Organism: Rat

Tissue: Brain

752
IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1

WJ Wu, SH Wang, CC Wu, YA Su, CY Chiang, CH Lai, TH Wang, TL Cheng, JY Kuo, TC Hsu, TH Lin, YJ Lee

International Journal of Molecular Sciences (MDPI) Taiwan, 05 November 2021

Reproductive Medicine

Key words: IL-4, IL-13, Mammary Glands, Cell Proliferation, STAT6, IRS Protein

Organism: Human

Cell Line: Mammary epithelial cells

753
Donor Bone Marrow Derived Macrophage Engraftment into the Central Nervous System of Allogeneic Transplant Patients

AM Loeb, SS Pattwell, A Bedalov, S Meshinchi, KR Loeb

Blood (ASH Publications) USA, 05 November 2021

Hematology

Organism: Human

Tissue: Bone Marrow

Pathological State: Allogeneic Transplantation

754
Cholesterol-lowering Intervention Decreases mTOR Complex 2 Signaling and Enhanced Antitumor Immunity

Y Wang, S You, S Su, A Yeon, E Lo, S Kim, J Mohler, MR Freeman, HL Kim

Clinical Cancer Research (AACR Publications) USA, 02 November 2021

Oncology

Organism: Human

Tissue: Prostate

Pathological State: Cancer

755
Whole-Brain Afferent Inputs to the Caudate Nucleus, Putamen, and Accumbens Nucleus in the Tree Shrew Striatum

RJ Ni, YM Shu, T Li, JN Zhou

Frontiers in Neuroanatomy (Frontiers Media S.A.) China, 02 November 2021

Neuroscience

Key words: Caudate Nucleus, Putamen, Accumbens Nucleus, Thalamus, Neural Circuits

Organism: Tree Shrew

Tissue: Brain

756
Self-extracellular RNA promotes pro-inflammatory response of astrocytes to exogenous and endogenous danger signals

S Fischer, E Nasyrov, M Brosien, KT Preissner, HM Marti, R Kunze

Journal of Neuroinflammation (BMC) Germany, 02 November 2021

Neuroscience

Key words: Extracellular RNA, Astrocyte, Inflammation, Stroke, Ischemia/Reperfusion, PAMP, DAMP, TLR

Organism: Mouse

Tissue: Brain

757
Expression of Vascular Cell Adhesion Molecule-1 in Peripheral Artery Disease is Enriched in Patients with Advanced Kidney Disease

PT Lee, IC Liao, CH Lee, LW Hsu, PY Liu

Acta Cardiologica Sinica (Taiwan Society of Cardiology) Taiwan, 01 November 2021

Cardiology

Key words: Chronic Kidney Disease, Hemodialysis

Organism: Human

Tissue: Kidney

Pathological State: Vascular Disease, Kidney Disease

758
SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway

CY Kuo, YC Chang, MN Chien,

Endocrine-Related Cancer (Society for Endocrinology) Taiwan, 01 November 2021

Oncology

Key words: SREBP1, Invasion, Thyroid Cancer, Lipid Metabolism

Organism: Human

Tissue: Thyroid

Pathological State: Cancer

759
Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer

BL Horton, DM Morgan, N Momin, M Zagorulya, E Torres-Mejia, V Bhandarkar, KD Wittrup, JC Love, S Spranger

Science Immunology (Science) USA, 29 October 2021

Oncology, Immunology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

760
Spatiotemporal Protein Expression Profiles of QSOX1 in the Murine Uterus, Placenta, and Embryo during Pregnancy

HS Lin, RKK Lee, TH Yang, HW Fang, SH Li

Applied Sciences (MDPI) Taiwan, 29 October 2021

Reproductive Medicine

Key words: Quiescin Sulfhydryl Oxidase 1, Uterus, Placenta, Embryo, Maternal-Fetal Interface, Tissue Distribution, Pregnancy

Organism: Mouse

Tissue: Uterus, Placenta, Embryo

Pathological State: Pregnancy

761
SPION NANOPARTICLES IN VITRO AND IN VIVOTESTING FOR ANTIMELANOMA DRUG RELEASE INTO TUMORS

M Doni, HF Oancea, HRC Fierăscu

The International Symposium PRIOrities of CHEMistry for a sustainable development (ICECHIM) Romania, 29 October 2021

Oncology, Nanomedicine

Key words: melanoma cells, syngeneic melanoma mouse model, drug delivery, IHC, RT-qPCR

Organism: Mouse

Tissue: Allograft Tumor

Pathological State: Cancer

762
Carboxypeptidase N1 is anticipated to be a synergy metrics for chemotherapy effectiveness and prognostic significance in invasive breast cancer

YY Fan, CH Liu, AL Wu, HC Chen, YJ Hsueh, KJ Chen, CC Lai, CY Huang, WC Wu

Cancer Cell International (Springer) China, 28 October 2021

Oncology

Key words: Carboxypeptidase N1, CA153, Chemotherapeutic Efficacy, Prognosis, Invasive Breast Cancer

Organism: Human

Tissue: Breast

Pathological State: Cancer

763
Increased osteogenic activity of dynamic cultured composite bone scaffolds: Characterization and in vitro study

ML Mueller, MP Ottensmeyer, JR Thamm, R Schmelzeisen, MJ Troulis, FPS Guastaldi

Journal of Oral and Maxillofacial Surgery (Elsevier) USA, Germany, 27 October 2021

Osteology

Key words: Scaffolds, Bone Tissue Engineering, Calcium Phosphate, 3D Printing, ALP

Organism: Human

Cell Line: pBMSCs

764
Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer

PF Yueh, YH Lee, I Chiang, WT Chen, KL Lan, CH Chen, FT Hsu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, USA, 26 October 2021

Oncology

Key words: Imipramine, Non-Small Cell Lung Cancer (NSCLC), EGFR - Epidermal Growth Factor Receptor, PKC-δ-Protein Kinase C Delta, NF-κB – Nuclear Factor Kappa B

Organism: Mouse

Tissue: Xenograft Tumor, Lung, Liver

Pathological State: Cancer

765
The prognostic value of TCF1+ CD8+ T in primary small cell carcinoma of the esophagus

L Ma, L Sun, K Zhao, Z Dong, Z Huang, X Meng

Cancer Science (Japanese Cancer Association) China, 25 October 2021

Oncology

Key words: prognosis, PSCCE, stem‐like, TCF1, tumor microenvironment

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

766
Metabolic memory underlying minimal residual disease in breast cancer

K Radic Shechter, E Kafkia, K Zirngibl, S Gawrzak, A Alladin, D Machado, C Lüchtenborg, DC Sevin, B Brügger, KR Patil, M Jechlinger

Molecular Systems Biology (EMBO press) Germany, UK, 25 October 2021

Oncology

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

767
Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction

LJ Renshall, F Beards, A Evangelinos, SL Greenwood, P Brownbill, A Stevens, CP Sibley, JD Aplin, ED Johnstone, T Teesalu, LK Harris

Pharmaceutics (MDPI) UK, USA, 25 October 2021

Reproductive Medicine

Key words: Placenta, Pregnancy, Fetal Growth Restriction, LLiposomes, Epidermal Growth Factor

Organism: Human

Tissue: Placenta

768
Cardiac Fibrosis Is a Risk Factor for Severe COVID-19

J Mustroph, J Hupf, MJ Baier, K Evert, C Brochhausen, K Broeker, C Meindl, B Seither, C Jungbauer, M Evert, LS Maier, S Wagner

Frontiers in Immunology (Frontiers Media S.A.) Germany, 22 October 2021

SARS-CoV-2

Key words: SARS-CoV-2, COVID-19, Fibrosis, Heart, TGF-β1, NRP-1

Organism: Human

Tissue: Heart

Pathological State: COVID-19

769
Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist

H Mei, Z Zha, W Wang, Y Xie, Y Huang, W Li, D Wei, X Zhang, J Qu, J Liu

Genome Biology (BMC) China, 22 October 2021

Genetics

Key words: CRISPR, Genome-wide screen, Surfaceome screen, Rhinovirus, OLFML3

Organism: Human

Pathological State: Rhinovirus Infection

Cell Line: HeLa cells

770
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

C Shen, R Li, R Negro, J Cheng, SM Vora, TM Fu, A Wang, K He, L Andreeva, P Gao, Z Tian, RA Flavell, S Zhu, H Wu

CELL (Cell Press) USA, China, Italy, 21 October 2021

Immunology, Virology

Key words: NLRP6, dsRNA, Liquid-Liquid Phase Separation, LLPS, Inflammasome, MHV, RV, IDRs

Organism: Mouse

Tissue: Liver

771
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

C Vinel, G Rosser, L Guglielmi, M Constantinou, N Pomella, X Zhang, JR Boot, TA Jones, TO Millner, AA Dumas, V Rakyan, J Rees, JL Thompson, J Vuononvirta, S Nadkarni, TE Assan, N Aley, YY Lin, P Liu, S Nelander, D Sheer, CLR Merry F Marelli-Berg, S Brandner, S Marino

Nature Communications (Nature) UK, Hong Kong, Sweden, 21 October 2021

Oncology

Key words: CNS Cancer, Reprogramming

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

772
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements

SM Zhang, WL Cai, X Liu, D Thakral, J Luo, LH Chan, MK McGeary, E Song, KRM Blenman, G Micevic, S Jessel, Y Zhang, M Yin, CJ Booth, LB Jilaveanu, W Damsky, M Sznol, HM Kluger, A Iwasaki, MW Bosenberg, Q Yan

Nature (Nature) USA, China, 20 October 2021

Oncology

Key words: Epigenetics, Melanoma

Organism: Mouse

Tissue: Allograft Tumor, Skin

Pathological State: Cancer

773
A Recurrent STAT5BN642H Driver Mutation in Feline Alimentary T Cell Lymphoma

M Kieslinger, A Swoboda, N Kramer, P Freund, B Pratscher, HA Neubauer, R Steinborn, B Wolfesberer, A Fuchs-Baumgartinger, R Moriggl, IA Burener

Cancers (MDPI) Austria, 19 October 2021

Oncology

Key words: STAT5B, driver mutation, feline alimentary lymphoma, STAT3

Organism: Cat

Tissue: Lymphoid Tissue

Pathological State: Cancer

774
Hippocampal and thalamic afferents form distinct synaptic microcircuits in the mouse infralimbic frontal cortex

K Graham, N Spruston, EB Bloss

Cell Reports (Cell Press) USA, 19 October 2021

Neuroscience

Key words: Frontal Cortex, circuit, Synapse, Interneuron, Projection neuron, rabies tracing, hippocampus, thalamus

Organism: Mouse

Tissue: Brain

775
Autophagy Upregulates miR-449a Expression to Suppress Progression of Colorectal Cancer

SH Lan, SC Lin, WC Wang, YC Yang, JC Lee, PW Lin, ML Chu, KY Lan, R Zuchini, HS Liu

Frontiers in Oncology (Frontiers Media S.A.) Taiwan, 19 October 2021

Oncology

Key words: autophagy, miR-449a, FoxO1, colorectal cancer, tumorigenesis

Organism: Human

Tissue: Colon

Pathological State: Cancer

776
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis

F Klemm, A Möckl, A Salamero-Boix, T Alekseeva, A Schäffer, M Schulz, K Niesel, RR Maas, M Groth, BT Elie, RL Bowman, ME Hegi, RT Daniel, PS Zeiner, J Zinke, PN Harter, KH Plate, JA Joyce, L Sevenich

Nature Cancer (Nature) Switzerland, Germany, USA, 18 October 2021

Oncology

Key words: Cancer, Cancer microenvironment, Cancer therapeutic resistance, Metastasis

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

777
Recent progress in cytometric technologies and their applications in ecotoxicology and environmental risk assessment

D Wlodkowic, A Czerw, B Karakiewicz, A Deptala

Cytometry Part A (Wiley) Australia, Poland, 15 October 2021

Toxicology

778
An Integrated Bile Acids Profile Determination by UHPLC-MS/MS to Identify the Effect of Bile Acids Supplement in High Plant Protein Diet on Common Carp (Cyprinus carpio)

X Wei, T Yao, FN Fall, M Xue, X Liang, J Wang, W Du, X Gu

Foods (MDPI) China, 15 October 2021

Gastroenterology

Key words: Bile Acids, Common Carp, High Plant Protein Diet, Hepatopancreas, Glycogen Accumulation, UHPLC-MS/MS

Organism: Common Carp

Tissue: Hepatopancreas

779
Siglec-15 Is an Immune Suppressor and Potential Target for Immunotherapy in the Pre-Metastatic Lymph Node of Colorectal Cancer

H Du, J Tang, X Li, X Wang, L Wu, R Zhang, P Hu, Y Yang

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 13 October 2021

Oncology

Key words: Pre-Metastatic Niche, Lymph Nodes, Colorectal Cancer, Immunosuppressive, SIGLEC15

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

780
LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure

CT Su, TM Jao, Z Urban, YJ Huang, DHW See, YC Tsai, WC Lin, JW Huang

Cell Death & Disease (Nature) Taiwan, 13 October 2021

Nephrology

Key words: Cell signalling, Pathogenesis

Organism: Mouse

Tissue: Kidney

Pathological State: Renal Fibrosis

781
Human resident memory T cells exit the skin and mediate systemic Th2-driven inflammation

J Strobl, LM Gail, L Kleissl, RV Pandey, V Smejkal, J Huber, V Puxkandl, L Unterluggauer, R Dindelmaier-Hovorka, D Atzmüller, T Krausgruber, C Bock, P Wohlfarth, W Rabitsch, G Stary

Journal of Experimental Medicine (Rockefeller University Press) Austria, 13 October 2021

Immunology

Organism: Human

Cell Line: Keratinocytes

782
Sexual dimorphism in the bed nucleus of the stria terminalis, medial preoptic area and suprachiasmatic nucleus in male and female tree shrews

RJ Ni, YM Shu, PH Luo, JN Zhou

Journal of Anatomy (Wiley) China, 12 October 2021

Reproductive Medicine

Organism: Tree Shrew

Tissue: Brain

783
Changes in expressions of spermatogenic marker genes and spermatogenic cell population caused by stress

P Tian, Z Zhao, Y Fan, N Cui, B Shi, G Hao

Frontiers in Endocrinology (Frontiers Media S.A.) China, 11 October 2021

Reproductive Medicine

Key words: Stress, Testis, Spermatogenesis, Gene, RNA Sequencing

Organism: Rat

Tissue: Testis

784
Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCs

L Johnson Chacko, H Lahlou, C Steinacher, S Assou, Y Messat, J Dudas, A Edge, B Crespo, M Crosier, C Sergi, A Schrott-Fischer, A Zine

International Journal of Molecular Sciences (MDPI) USA, France, UK, Canada, 07 October 2021

Genetics

Key words: Human Induced Pluripotent Stem Cells, Otic Sensory Progenitors, Gene Expression Analysis, Extracellular Matrix, Integrins, Human Fetal Inner Ear

Organism: Human

Tissue: Bone

785
Glucose/Glutathione Co-triggered Tumor Hypoxia Relief and Chemodynamic Therapy to Enhance Photothermal Therapy in Bladder Cancer

WH Chen, KJ Yu, JW Jhou, HH Pang, WH Wenig, WS Lin, HW Yang

ACS Applied Bio Materials (ACS Publications) Taiwan, 07 October 2021

Oncology, Pharmacology

Key words: Photothermal Therapy, Chemodynamic Therapy, Manganese Dioxide (MnO2), Tumor Hypoxia, Bladder Cancer

Organism: Mouse

Tissue: Bladder

Pathological State: Cancer

786
Irreversible depletion of intestinal CD4+ T-cells is associated with T-cell activation during chronic HIV infection

OE Asowata, A Singh, A Ngoepe, N Herbert, R Faradoos, K Reddy, Y Zuingu, F Nene, N Mthabela, D Ramjit, K Govender, T Ndung'u, JZ Porterfield, JH Adamson, FG Madela, VT Manzini, F Anderson, A Leslie, HN Kløverpris

JCI Insight (American Society of Clinical Investigation) South Africa, Denmark, UK, Germany, USA, 07 October 2021

Immunology, Virology

Organism: Human

Tissue: Small Intestine

Pathological State: HIV Infection

787
Characterizing the host response to rhPDGF‐BB in a rat spinal arthrodesis model

JT Yamaguchi, JA Weiner, S Minardi, AC Greene, DJ Ellenbogen, MJ Hallman, VP Shah, KM Weisz, S Jeong, T Nandurkar, C Yun, WK Hsu, EL Hsu

JOR Spine (Wiley) USA, 07 October 2021

Osteology

Organism: Mouse

Tissue: Bone

788
An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

B Wang, L Wang, NS Gasek, Y Zhou, T Kim, C Guo, ER Jellison, L Haynes, S Yadav, T Tchkonia, GA Kuchei, JL Kirkland, M Xu

Nature Aging (Nature) USA, China, 07 October 2021

Aging

Key words: Ageing, Animal biotechnology, Senescence

789
Conditioned CAR-T cells by hypoxia-inducible transcription amplification (HiTA) system significantly enhances systemic safety and retains antitumor efficacy

H He, Q Liao, C Zhao, C Zhu, M Feng, Z Liu, L Jiang, L Zhang, X Ding, M Yuan, X Zhang, J Xu

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 06 October 2021

Oncology

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

790
Landscape of prognostic signatures and immunogenomics of the AXL/GAS6 axis in renal cell carcinoma

K Hakozaki, N Tanaka, K Takamatsu, R Takashi, Y Yasumizu, S Mikami, T Shinojima, K Kakimi, T Kamatani, F Miya, T Tsunoda, E Aimono, H Nishihara, R Mizuno, M Oya

British Journal of Cancer (Nature) Japan, 05 October 2021

Oncology

Key words: Renal Cell Carcinoma, Tumour Biomarkers

Organism: Human

Tissue: Kidney

Pathological State: Cancer

791
NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression

J Liang, W Sun, H Song, C Wang, Q Li, C Li, D Wie, Y Zhao, C Li, H Zhang

Epigenomics (Future Medicine) China, 05 October 2021

Oncology, Pharmacology

Key words: Epithelial–Mesenchymal Transition, NOL6, Nucleolar Protein, Tumorigenesis, TWIST1

Organism: Human

Tissue: Endometrium

Pathological State: Cancer

792
Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis

NS Dey, S Senaratne, V Somaratne, NP Madarasinghe, B Seneviratne, S Forrester, M Montes de Oca, L Capos Reis, S Moulik, PB Walrad, M Chatterjee, H Goto, R Wickremasinghe, D Lagos, PM Kaye, S Ranasinghe

The Journal of Clinical Investigation (American Society of Clinical Investigation) UK, Sri Lanka, Brazil, India, 05 October 2021

Immunology, Parasitology

Key words: Immunology, Infectious Disease

Organism: Human

Tissue: Skin

Pathological State: Leishmaniasis, Dermal lesions

793
Two ST11 Klebsiella pneumoniae strains exacerbate colorectal tumorigenesis in a colitis-associated mouse model

MK Chiang, PY Hsiao, YY Liu, HL Tang, CS Chiou, MC Lu, YC Lai

Gut Microbes (Taylor & Francis) Taiwan, 04 October 2021

Oncology, Microbiology

Key words: Klebsiella Pneumoniae, ST11, Colorectal Tumorigenesis, IL-10, M2 Macrophages

Organism: Mouse

Tissue: Colon

Pathological State: Klebsiella Infection, Cancer

794
Epstein-Barr Virus Promotes Tumor Angiogenesis by Activating STIM1-Dependent Ca2+ Signaling in Nasopharyngeal Carcinoma

J Ye, J Wei, Y Luo, Y Deng, T Que, X Zhang, F Liu, J Zhang, X Luo

Pathogens (MDPI) China, 03 October 2021

Oncology, Virology

Key words: Epstein-Barr Virus, Stromal Interaction Molecule 1, Tumor Angiogenesis, Nasopharyngeal Carcinoma

Organism: Human

Tissue: Nasopharynx

Pathological State: Cancer

795
Loss of host tissue transglutaminase boosts antitumor T cell immunity by altering STAT1/STAT3 phosphorylation in ovarian cancer

LE Sima, S Chen, H Cardenas, G Zhao, Y Wang, C Ivan, H Huang, B Zhang, D Matei

Journal for ImmunoTherapy of Cancer (BMJ Journals) USA, Romania, 30 September 2021

Oncology

Organism: Mouse

Tissue: Ovaries

Pathological State: Cancer

796
Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer's Disease in nonhuman primates

F Yue, S Feng, C Lu, T Zhang, G Tao, J Liu, C Yue, N Jing

iScience (Cell Press) China, 30 September 2021

Neuroscience

Key words: Alzheimer's Disease, Non-Human Primate, Aβ Oligomers, Aβ Plaques, Tau Tangles, Animal Model

Organism: Monkey

Tissue: Brain

Pathological State: Alzheimer's Disease

797
Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice

MMT Islam, D Tarnowski, M Zhang, M Trum, S Lebek, J Mustroph, H Daniel, J Moellencamp, S Pabel, S Sossalla, A El-Armouche, VO Nikolaev, AM Shah, P Eaton, LS Maier, CM Sag, S Wagner

Journal of the American Heart Association (AHA Journals) Germany, Bangladesh, UK, 29 September 2021

Cardiology

Key words: Pressure Overload, Redox, Protein Kinase A, Heart Failure

Organism: Mouse

Tissue: Heart

Pathological State: Heart Failure

798
Turning up the heat on non-immunoreactive tumors: pyroptosis influences the tumor immune microenvironment in bladder cancer

X Chen, H Chen, H Yao, K Zhao, Y Zhang, D He, Y Zhu, Y Cheng, R Liu, R Xu, K Cao

Oncogene (Nature) China, Sweden, 29 September 2021

Oncology

Key words: Cancer Microenvironment, Cell Death and Immune Response, Predictive Markers

Organism: Human

Tissue: Bladder

Pathological State: Cancer

799
Adaptive metabolic responses in a thermostabilized environment: Transgenerational trade-off implications from tropical tilapia

MC Wang, MT Hsu, CC Lin, SC Hsu, RD Chen, JR Lee, YL Chou, HP Tseng, F Furukawa, SPL Hwang, PP Hwang, YC Tseng

Science of The Total Environment (Elsevier) Taiwan, Japan, 29 September 2021

Genetics, Ecology

Key words: Thermal Variance, Cold Exposure, Transgenerational Plasticity, Metabolism, Tropical Fish

Organism: Fish

Tissue: Liver

800
Human Milk Oligosaccharides alleviate stress-induced visceral hypersensitivity and associated microbiota dysbiosis

L Ferrier, H Eutamène, L Siegwald, AM Marquard, V Tondereau, J Chevalier, GE Jacot, L Favre, V Theodorou, M Vicario, A Rytz, G Bergonzelli, CL Garcia-Rodenas

The Journal of Nutritional Biochemistry (Elsevier) Switzerland, France, Denmark, 25 September 2021

Gastroenterology

Key words: HMOs, Abdominal Pain, Chronic Psychological Stress, Antibiotics, Microbiome, Metagenomic

Organism: Mouse

Tissue: Colon

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