Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

Filter publications

Customer Publications (A total of 2648 papers published)

401
Role of Artificial Intelligence in Cancer Diagnosis and Drug Development

S Srivastava, D Paliwal

Combinatorial Chemistry & High Throughput Screening (Ingenta conect) , 02 December 2022

Oncology

Key words: Cancer, artificial intelligence, computational approach, deep learning, drug development, machine learning

402
Sex-based difference in response to recombinant human bone morphogenetic protein-2 in a rat posterolateral fusion model

JP Foley, EJ Fred, S Minardi, JT Yamaguchi, AC Greene, AA Furman, JG Lyons, JT Paul, TS Nandurkar, KR Blank, RM Havey, M Muriuki, AG Patwardhan, WK Hsu, SR Stock, EL Hsu

Spine (Ingenta conect) USA, 01 December 2022

Key words: BMP, BMP-2, bone, healing, regeneration, rhBMP-2, sex, sex-dependent differences, spinal fusion, spine

403
Tactile cues are important to environmental novelty during repeated open field tests

W Chen, Z Wang, C Ma, X Ma, W Meng, F Yin, Y Yang

Behavioural Processes (Elsevier) China, 30 November 2022

Zoology

Key words: Anxiety, CA1, Environment, Open field test, Repeated testing, Tactile

Organism: Mouse

Tissue: Brain

404
Xenobiotic-induced ribosomal stress compromises dysbiotic gut barrier aging: A one health perspective

J Sun, J Kim, H Jeong, D Kwon, Y Moon

Redox Biology (Elsevier) South Korea, 30 November 2022

Toxicology

Key words: Gut aging, Ribosomal stress, Deoxynivalenol, Gut barrier, Microbiota

Organism: Mouse

Tissue: Small Intestine

405
MiR-140 is involved in T-2 toxin-induced matrix degradation of articular cartilage

Y Shi, X Shao, M Sun, J Ma, B Li, N Zou, F Li

Toxicon (Elsevier) China, 30 November 2022

Toxicology

Key words: miR-140, T-2 toxin, KBD, Articular cartilage, Extracellular matrix

Organism: Mouse

Tissue: Joint Tissue

406
Blockade of c-Met-Mediated Signaling Pathways by E7050 Suppresses Growth and Promotes Apoptosis in Multidrug-Resistant Human Uterine Sarcoma Cells

TT Huang, CM Chen, YW Lan, SS Lin, KB Choo, KY Chong

International Journal of Molecular Sciences (MDPI) Taiwan, USA, Malaysia, 28 November 2022

Pharmacology, Oncology

Key words: E7050, multidrug-resistant uterine sarcoma, apoptosis, cell cycle arrest, c-Met

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

407
The divergent effects of astrocyte ceruloplasmin on learning and memory function in young and old mice

ZD Li, H Li, S Kang, YG Cui, H Zheng, P Wang, K Han, P Yu, YZ Chang

Cell Death & Disease (Nature) China, 28 November 2022

Neuroscience

Key words: Alzheimer's disease, Cognitive ageing

Organism: Mouse

Tissue: Brain

408
Aspirin curcumin ester loaded biomimetic nanodrug improves cognitive deficits in a mouse model of Alzheimer's disease by regulating M1/M2 microglial polarization

Z Li, Z Song, C He, J Fan, W Yu, M Yang, P Li, R Luo, J Zhou, S Xu, B Liu, S Cheng

Materials Today Advances (Elsevier) China, 26 November 2022

Nanomedicine

Key words: Alzheimer's disease, Microglia, Neuroinflammation, Nanoparticle, APP/PS1

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

409
3, 3′-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy

H Tang, K Qin, A Wang, S Li, S Fang, W Gao, M Lu, W Huang, H Zhang, Z Yin

Frontiers in Pharmacology (Frontiers Media S.A.) China, 25 November 2022

Osteology

Key words: 3, 3′-diindolylmethane, osteoarthritis, apoptosis, autophagy, chondrocyte

Organism: Human

Cell Line: Chondrocytes

410
Co-assembled Nanocarriers of De Novo Thiol-Activated Hydrogen Sulfide Donors with an RGDFF Pentapeptide for Targeted Therapy of Non-Small-Cell Lung Cancer

H Chen, X Guan, Q Liu, L Yang, J Guo, F Gao, Y Qi, X Wu, F Zhang, X Tian

ACS Applied Materials & Interfaces (ACS Publications) China, 22 November 2022

Oncology, Nanomedicine

Key words: thiol-activated hydrogen sulfide donors, targeted pentapeptide, coassembled nanocarrier, non-small cell lung cancer, combined radiotherapy

Organism: Mouse

Tissue: Heart, Liver, Spleen, Lung, Kidney

Pathological State: Cancer

411
Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression

D Yang, H Liu, Y Cai, K Lu, X Zhong, S Xing, W Song, Y Zhang, L Ye, X Zhu, T Wang, P Zhang, ST Li, J Feng, W Jia, H Zhang, ST Li, J Feng, W Jia, H Zhang, P Gao

Cell Reports (Cell Press) China, 22 November 2022

Oncology

Key words: branch-chain amino acid, glutamine-depravation, O-GlcNAcylation, HCC progression

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

412
Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling

HC Wang, LY Haung, CJ Wang, YJ Chao, YC Hou, CJ Yen, YS Shan

Journal of Biomedical Science (BMC) Taiwan, 21 November 2022

Oncology

Key words: Hepatocellular carcinoma, Sorafenib resistance, Tumor-associated macrophage, CXCR2, CXCL1, CXCL2

Organism: Human

Tissue: Liver

Pathological State: Cancer

413
Overcoming oxygen heterogeneity of tumor microenvironments to boost cancer immunotherapy by oxygen-switchable ROS/RNS nanogenerators

W Jiang, Z Shen, Z Guo, Q Wang, Q Li, J Hu, Y Wang

Nano Today (Elsevier) China, 21 November 2022

Oncology

Key words: Oxygen-switchable ROS/RNS-releasing polymers, Oxygen heterogeneity, Immunogenic cell death, Cancer immunotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

414
Over-expression of CRTH2 indicates eosinophilic inflammation and poor prognosis in recurrent nasal polyps

W Chen, S He, X Xie, X Yang, C Duan, P Ye, X Li, MG Lawrence, L Borish, X Feng

Frontiers in Immunology (Frontiers Media S.A.) China, USA, 18 November 2022

Pathology

Key words: chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2), chronic rhinosinusitis with nasal polyps, eosinophils, prognosis, recurrent nasal polyp.

Organism: Human

Tissue: Mucosa

Pathological State: Nasal Polyps

415
EBV persistence in gastric cancer cases conventionally classified as EBER-ISH negative

MC Siciliano, S Tornambè, G Cevenini, E Sorrentino, M Granai, G Giovannoni, D Marelli, I Biviano, F Roviello, H Yoshiyama, L Leoncini, S Lazzi, L Mundo

Infectious Agents and Cancer (BMC) Italy, Germany, Japan, Ireland, 17 November 2022

Virology, Oncology

Key words: Gastric adenocarcinoma, Gastric cancer with lymphoid stroma, Epstein Barr Virus, Hit and run mechanism

Organism: Human

Tissue: Stomach

Pathological State: Cancer

416
Formation of the glomerular microvasculature is regulated by VEGFR-3

MD Donnan, DK Deb, T Onay, R Paz Scott, E Ni, Y Zhou, SE Quaggin

American Journal of Physiology (American Physiological Society) USA, 17 November 2022

Physiology

Key words: development, glomerulus, kidney, vascular endothelial growth factor receptor 3, vasculature

Organism: Mouse

Tissue: Kidney

417
Targeting VEGF-A/VEGFR2 Y949 Signaling-Mediated Vascular Permeability Alleviates Hypoxic Pulmonary Hypertension

W Zhou, K Liu, L Zeng, J He, X Gao, X Gu, X Chen, JJ Li, M Wang, D Wu, Z Cai, L Claesson-Welsh, R Ju, J Wang, F Zhang, Y Chen

Circulation (AHA Journals) China, Sweden, 17 November 2022

Cardiology

Key words: single-cell RNA sequencing, smooth muscle, Src family kinase, vascular permeability, hypoxic pulmonary hypertension, VEGF-A, macrophage, VEGFR2 Y949

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Hypertension

418
Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

EM Crombie, S Kim, S Adamson, H Dong, TC Lu, Y Wu, Y Wu, Y Levy, N Stimple, WMR Lam, HWD Hey, DJ Withers, AL Hsu, BH Bay, J Ochala, SY Tsai

Journal of Cachexia, Sarcopenia and Muscle (Wiley) Singapore, USA, Taiwan, UK, Denmark, 17 November 2022

Rheumatology

Organism: Mouse

Tissue: Muscle

419
Peroxidase-mimicking TA-VOx nanobranches for enhanced photothermal/chemodynamic therapy of glioma by inhibiting the expression of HSP60

Q Guo, M Yin, J Fan, Y Yang, T Liu, H Qian, X Dai, X Wang

Materials & Design (Elsevier) China, 17 November 2022

Nanomedicine

Key words: Glioblastoma, Photothermal therapy, Chemodynamic therapy, Peroxidase-mimicking, HSP60

Organism: Human

Tissue: Brain

Pathological State: Cancer

420
Cbln1 regulates axon growth and guidance in multiple neural regions

P Han, Y She, Z Yang, M Zhuang, Q Wang, X Luo, C Yin, J Zhu, SR Jaffrey, SJ Ji

PLoS Biology (Plos) USA, China, 17 November 2022

Neuroscience

Key words: Axons, Spinal cord, Neurons, Axon guidance, Chemoattractant axon guidance, Retinal ganglion cells, Immunostaining, In situ hybridization

Organism: Mouse

Tissue: Spinal Cord

421
Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer

WJ Cheng, SY Lin, KH Chuang, M Chen, HO Ho, LC Chen, CM Hsieh, MT Sheu

International Journal of Nanomedicine (Taylor & Francis) Taiwan, 16 November 2022

Nanomedicine, Oncology

Key words: docetaxel, pictilisib, nanocarriers, bispecific antibodies, dual epitopes, HER2-positive breast cancer

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

422
Porous scaffold for mesenchymal cell encapsulation and exosome-based therapy of ischemic diseases

A Czosseck, MM Chen, H Nguyen, A Meeson, CC Hsu, CC Chen, TA George, SC Ruan, YY Cheng, PJ Lin, PCH Hsieh, DJ Lundy

Journal of Controlled Release (Elsevier) Taiwan, UK, 14 November 2022

Cardiology, Nanomedicine

Key words: Myocardial infarction, Limb ischemia, Extracellular vesicle, Cell encapsulation, Cell therapy, ExosomeIschemic disease, Cardiac patch

423
Hypothermia evoked by stimulation of medial preoptic nucleus protects the brain in a mouse model of ischaemia

S Zhang, X Zhang, H Zhong, X Li, Y Wu, J Ju, B Liu, Z Zhang, H Yan, Y Wang, K Song, ST Hou

Nature Communications (Nature) China, 12 November 2022

Neuroscience

Key words: Mouse, Stroke

Organism: Mouse

Tissue: Brain

424
Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma

B Yan, L Liu, L Zhao, U Hinz, Y Luo, X An, J Gladkich, C de la Torre, Z Huang, D Schrapel, W Gross, F Fortunato, M Schaefer, MM Gaida, I Herr

Matrix Biology (Elsevier) Germany, 11 November 2022

Oncology, Endocrinology

Key words: Pancreatic cancer, Tumor microenvironment, Pancreatic stellate cells, Collagen type VIII alpha 1 chain, Gemcitabine

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

425
Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice

F Zhang, H Zhen, H Cheng, F Hu, Y Jia, B Huang, M Jiang

Frontiers in Cell and Developmental Biology (Frontiers Media S.A.) China, 10 November 2022

Hepathology

Key words: DEHP, liver injury, ferroptosis, endocrine disrupting chemical, pregnancy

Organism: Mouse

Tissue: Liver

426
Response of cadmium adsorption to three-year different agronomic managements in tropical soil: The role of P fractions and Fe oxides

B Liu, C Wei, D Wei, M Chen, W Li, P Pan, B Lin, L Wu, Q Li, Z He

Agriculture, Ecosystems Environment (Elsevier) China, USA, 10 November 2022

Ecology

Key words: Tropical soil, Corn-pepper rotation, Fertilization, Heavy metal, Soil aggregates

Organism: Soil

427
Transthyretin attenuates TDP-43 proteinopathy by autophagy activation via ATF4 in FTLD-TDP

YP Chu, LW Jin, LC Wang, PC Ho, WY Wei, KJ Tsai

Brain (Oxford Academic) Taiwan, USA, 10 November 2022

Cell Biology

Key words: TTR, TDP 43, proteinopathy, ATF4, FTLD

Organism: Mouse

Tissue: Brain

428
Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone cement to repair critical bone defects

S Li, L Zhang, C Liu, J Kim, K Su, T Chen, L Zhao, X Lu, H Zhang, Y Cui, X Cui, F Yuan, H Pan

Bioactive Materials (Elsevier) China, 09 November 2022

Osteology

Key words: Borosilicate glass bone cement, Immunomodulation, Angiogenesis, Osteogenesis

Organism: Rabbit

Tissue: Bone

429
Expression and clinical significance of VISTA, B7-H3, and PD-L1 in glioma

LC Wang, YL Wang, B He, YJ Zheng, HC Yu, ZY Liu, RR Fan, X Zan, RC Liang, ZP Wu, X Tang, GQ Wang, JG Xu, LX Zhou

Clinical Immunology (Elsevier) China, 08 November 2022

Oncology

Key words: VISTA, B7-H3, PD-L1, Glioma, mIF

Organism: Human

Tissue: Brain

Pathological State: Cancer

430
Influence of PRRSV-1 vaccination and infection on mononuclear immune cells at the maternal-fetal interface.

MR Stas, H Kreutzmann, J Stadler, EL Sassu, KH Mair, M Koch, C Knecht, M Stadler, M Dolezal, G Balka, M Zaruba, M Mötz, A Saalmüller, T Rümenapf, W Gerner, A Ladinig

Frontiers in Immunology (Frontiers Media S.A.) Austria, Germany, 08 November 2022

Virology, Immunology

Key words: PRRSV, porcine maternal-fetal interface, NK cells, γδ T cells, B cells, CD4 T cells, CD8 T cells

Organism: Pig

Tissue: Placenta

431
Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia

WC Schrottmaier, JB Kral-Pointner, M Salzmann, M Mussbacher, A Schmuckenschlager, A Pirabe, L Brunnthaler, M Kuttke, B Maier, S Heber, H Datler, Y Ekici, B Niederreiter, U Heber, B Blomgren, AD Gorki, C Söderberg-Nauclé, B Payrastre, MP Gratacap, S Knapp, G Schabbauer, A Assinger

Cell Reports (Cell Press) Austria, Sweden, France, 08 November 2022

Immunology

Key words: platelet, PI3K, p110 inhibitor, streptococcus, pneumonia, infection, inflammation, leukocyte recruitment, immunomodulation

Organism: Mouse

Tissue: Lung

Pathological State: Pneumonia

432
An Early Islet Transcriptional Signature is Associated with Local Inflammation in Autoimmune Diabetes

AG Derr, A Arowosegbe, B Satish, SD Redick, N Qaisar, Z Guo, E Vanderleeden, MI Trombly, CE Baer, DL Greiner, M Garber, JP Wang

Diabetes (American Diabetes Association) USA, 08 November 2022

Endocrinology

Key words: Type 1 diabets, autoimmune disease/disorders, rat pancreatic islet, virus, single-cell RNA (scRNA) sequencing

Organism: Rat

Tissue: Pancreas

Pathological State: Diabetes Type 1

433
Proteome expression profiling of red blood cells during the tumorigenesis of hepatocellular carcinoma

S Wang, G Wang, S Lu, J Zhang, W Zhang, Y Han, X Cai, Y Zhuang, F Pu, X Yan, Z Tu, L Wang, X Huang, B Fan, D Wang, Z Zhang

Plos one (Plos) China, 08 November 2022

Oncology

Key words: Lung and intrathoracic tumors, Hepatocellular carcinoma, Carcinogenesis, Blood, Biomarkers, Cancer detection and diagnosis, Hemoglobin, Globins

Organism: Human

Tissue: Liver

Pathological State: Cancer

434
Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1, 2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway

Y Zheng, N Gao, W Zhang, R Ma, F Chi, Z Gao, N Cong

Molecular Neurobiology (Springer) China, 05 November 2022

Pharmacology

Key words: Melatonin, Pyroptosis, Cochlear hair cell, Oxygen–glucose deprivation/reperfusion

Cell Line: HEI-OC1 cells

435
Prx1+ MPCs Accumulate in the Dura Mater of Wild‐Type and p21−/− Mice Followed by a Specific Reduction in p21−/− Dural MPCs

SS Shah, PT Salo, FG Lyons, AP Mitha, RJ Krawetz

Advanced Biology (Wiley) Canada, 03 November 2022

Physiology

Organism: Mouse

Tissue: Adipose Tissue

436
Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions

N Yang, Y Wang, Q Tian, Q Wang, Y Lu, L Sun, S Wang, Y Bei, J Ji, H Zhou, W Yang, P Yao, W Zhu, L Sun, Z Huang, X Li, P Shen

Cell Death & Differentiation (Nature) China, USA, 03 November 2022

Cell Biology

Key words: Cell biology, Molecular biology

Organism: Human

Tissue: Adipose Tissue

437
Association of neutrophil extracellular traps with fistula healing in patients with complex perianal fistulising Crohn's disease

D Cao, K Qian, Y Zhao, J Hong, H Chen, X Wang, N Yang, C Zhang, J Cao, K Jia, G Wu, M Zhu, J Shen, Y Zhang, Z Cui, Z Wang

Journal of Crohn's and Colitis (Oxford Academic) China, 02 November 2022

Gastroenterology

Key words: Perianal fistulising Crohn's disease, Neutrophil extracellular traps, Fistula healing

438
Aberrant Expression of Thymosin Beta-4 Correlates With Advanced Disease and BRAF V600E Mutation in Thyroid Cancer

CY Kuo, JY Jhuang, WC Huang, SP Cheng

Journal of Histochemistry & Cytochemistry (SAGE Journals) Taiwan, 02 November 2022

Oncology, Genetics

439
p38α in the preoptic area inhibits brown adipose tissue thermogenesis

J Wang, S Wu, H Zhan, W Bi, Y Xu, Y Liang, Y Ge, L Peng, X Jin, K Lu, J Zhao, L Gao, Z He

Obesity (Wiley) China, 02 November 2022

Endocrinology

Organism: Mouse

Tissue: Liver, Adipose Tissue

440
Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma

M Mo, X Ma, Y Luo, C Tan, B Liu, P Tang, Q Liao, S Liu, H Yu, D Huang, X Zeng, X Qiu

BMC Cancer (BMC) China, 26 October 2022

Oncology

Key words: Hepatocellular carcinoma, Liver-specific lncRNA, FAM99A, Prognosis, Tumor growth

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

441
Whole-brain mapping of metabolic alterations in a mouse model of Alzheimer's disease by desorption electrospray ionization mass spectrometry imaging

X Wang, X Yang, Z Hou, S Tian, G Xu, J Li, L Wen, D Bi, F Gao, Y Shen, G Huang

Talanta (Elsevier) China, 26 October 2022

Neuroscience

Key words: Alzheimer's disease, Mass spectrometry imaging, Metabolic pathway, Glutamine-glutamate/GABA cycle, Neuronal activity

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's disease

442
A Combination of Virulent and Non-Productive Phages Synergizes the Immune System against Salmonella Typhimurium Systemic Infection

L Liang, J Huang, K Cui, P Li, W Shi, F Lin, G Hao, S Sun

International Journal of Molecular Sciences (MDPI) China, 24 October 2022

Immunology, Infectious Diseases

Key words: Salmonella Typhimurium, phage cocktail, immunophage synergy, lysis from without, phage resistance

Organism: Mouse

Tissue: Spleen, Liver, Kidney, Lung

Pathological State: Salmonella Typhimurium Infection

443
Tumor infiltrating CD8/CD103/TIM-3-expressing lymphocytes in epithelial ovarian cancer co-express CXCL13 and associate with improved survival

M Vlaming, V Bilemjian, JÁ Freile, V Melo, A Plat, G Huls, HW Nijman, M de Bruyn, E Bremer

Frontiers in Immunology (Frontiers Media S.A.) The Netherlands, 21 October 2022

Oncology

Key words: CXCL13, RNA-seq, TIM-3, epithelial ovarian cancer, tumor infiltrating lymphocytes

Organism: Human

Tissue: Ovaries

Pathological State: Cancer

444
HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control

R Fardoos, S Nyquist, O Asowata, SW Kazer, A Singh, A Ngoepe, J Giandhari, N Mthabela, D Ramjit, S Singh, F Karim, S Buus, F Anderson, JZ Porterfield, AL Sibiya, R Bipath, K Moodley, W Kuhn, B Berger, S Nguyen, T de Oliveira, T Ndung'u, P Goulder, AK Shalek, A Leslie, HN Kløverpris

Frontiers in Immunology (Frontiers Media S.A.) South Africa, Denmark, USA, UK, 18 October 2022

Immunology

Key words: CD8+ TRM cells, HIV, PD-1, tonsils, exhaustion, natural HIV control

Organism: Human

Tissue: Tonsil

Pathological State: HIV Infection

445
Intermittent Fasting Attenuates Hallmark Vascular and Neuronal Pathologies in a Mouse Model of Vascular Cognitive Impairment

V Rajeev, DY Fann, QN Dinh, HA Kim, TM De Silva, DG Jo, GR Drummond, CG Sobey, MKP Lai, CLH Chen, TV Arumugam

International Journal of Biological Sciences (Ivyspring International Publisher) Singapore, Australia, South Korea, 17 October 2022

Neuroscience

Key words: Vascular dementia, Vascular cognitive impairment, Intermittent fasting, Neuronal death, White matter lesions, Blood brain barrier breakdown, Chronic cerebral hypoperfusion

Organism: Mouse

Tissue: Brain

446
Nano-integrated Cascade Antioxidase Opsonized by Albumin Bypass the Blood-Brain Barrier for Ischemia-Reperfusion Injury

W Wang, Z Zhang, Y Liu, L Kong, W Li, W Hu, Y Wang, X Liu

Biomaterials Science (Royal Society of Chemistry) China, 17 October 2022

Nanomedicine

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

447
Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains

X Chen, Y Sun, L Chen, X Chen, M Pan, Y Zhang, Q Wang, W Yang, P Yin, D He, X Guo, S Yang, Y Zeng, S Yan, XJ Li, S Li

Cellular and Molecular Life Sciences (Springer) China, 17 October 2022

Neuroscience

Key words: Huntington disease, Neurogenesis, Aging, Neurodegeneration, Primate

Organism: Mouse, Monkey

Tissue: Brain

448
The NQO1/p53/SREBP1 axis promotes hepatocellular carcinoma progression and metastasis by regulating Snail stability

X Wang, Y Liu, A Han, C Tang, R Xu, L Feng, Y Yang, L Chen, Z Lin

Oncogene (Nature) China, 17 October 2022

Oncology

Key words: Cancer metabolism, Tumour angiogenesis, Tumour biomarkers

Organism: Human

Tissue: Liver

Pathological State: Cancer

449
The mesocolic apical fragment in complete mesocolic excision colectomies: should it be analysed separately? A proof‐of‐concept study

C Livadaru, S Morarasu, R Bargaoanu, S Iacob, T Frunza, AM Musina, N Velenciuc, CE Roata, F Zugun-Eloae, D Ferariu, S Lunca, MG Dimofte

Colorectal Disease (Wiley) Romania, 13 October 2022

Gastroenterology

Key words: central lymph nodes, CME, colon cancer, rectal cancer

Organism: Human

Tissue: Colon

Pathological State: Cancer

450
Licoricidin combats gastric cancer by targeting the ICMT/Ras pathway in vitro and in vivo

H Ma, F Wu, Y Bai, T Wang, S Ma, L Guo, G Leng, Y Kong, Y Zhang

Frontiers in Pharmacology (Frontiers Media S.A.) China, 13 October 2022

Pharmacology, Oncology

Key words: Licoricidin, gastric cancer, proteomics, ICMT, cancer therapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

451
Disturbances in microbial skin recolonization and cutaneous immune response following allogeneic stem cell transfer

N Bayer, B Hausman, RV Pandey, F Deckert, LM Gail, J Strobl, P Pjevac, C Krall, L Unterluggauer, A Redl, V Bachmayr, L Kleissl, M Nehr, R Kirkegaard, A Makristathis, ML Watzenboeck, R Nica, C Staud, L Hammerl, P Wohlfarth, RC Ecker, S Knapp, W Rabitsch, D Berry, G Stary

Leukemia (Nature) Austria, Australia, 12 October 2022

Immunology, Transplantation Medicine

Key words: Bone marrow transplantation, Immunosurveillance

Organism: Human

Tissue: Skin

452
High Presence of NETotic Cells and Neutrophil Extracellular Traps in Vaginal Discharges of Women with Vaginitis: An Exploratory Study

F Zambrano, A Melo, R Rivera-Concha, M Schulz, P Uribe, F Fonseca-Salamanca, X Ossa, A Taubert, C Hermosilla, R Sánchez

Cells (MDPI) Chile, Germany, 11 October 2022

Reproductive Medicine

Key words: neutrophil extracellular traps, Candida albicans, Trichomonas vaginalis, bacterial vaginosis, infectious vaginitis

Organism: Human

Cell Line: Vaginal smear

453
Quercetin inhibits the amphiregulin/EGFR signaling‐mediated renal tubular epithelial‐mesenchymal transition and renal fibrosis in obstructive nephropathy

Q Wang, F Wang, X Li, Z Ma, D Jiang

Phytotherapy Research (Wiley) China, 11 October 2022

Nephrology

Key words: amphiregulin, epidermal growth factor receptor, epithelial to mesenchymal transition, kidney,quercetin

Organism: Rat

Tissue: Kidney

Pathological State: Renal fibrosis

454
Extracellular Vesicles Derived from Lung Cancer Cells Induce Transformation of Normal Fibroblasts into Lung Cancer-Associated Fibroblasts and Promote Metastasis of Lung Cancer by Delivering lncRNA HOTAIR

X Zhang, Y Zhang, X Qiu, J Cai, Z Yang, F Song

Stem Cells International (Hindawi Publishing Corporation) China, 11 October 2022

Oncology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

455
Lumbrokinase regulates endoplasmic reticulum stress to improve neurological deficits in ischemic stroke

YH Wang, JM Liao, KM Chen, HH Su, PH Liu, YH Chen, YS Tsuei, CF Tsai, SS Huang

Neuropharmacology (Elsevier) Taiwan, 09 October 2022

Neuroscience

Key words: Lumbrokinase, Ischemic stroke, ER stress, IRE1, NLRP3

Organism: Mouse

Tissue: Brain

Pathological State: Cerebral Ischemia

456
Aging-associated REGγ proteasome decline predisposes to tauopathy

J Tu, H Zhang, T Yang, Y Liu, S Kibreab, Y Zhang, L Gao, RE Moses, BWO Malley, J Xiao, Xiaotao Li

Journal of Biological Chemistry (Elsevier) China, 07 October 2022

Neuroscience

Organism: Mouse

Tissue: Brain

457
Spinal cord from body donors is suitable for multicolor immunofluorescence

LF Reissig, G Carrero-Rojas, U Maierhofer, AS Moghaddam, A Hainfellner, B Gesslbauer, T Haider, J Streicher, OC Aszmann, AM Pastor, WJ Weninger, R Blumer

Histochemistry and Cell Biology (Springer) Austria, Spain, 06 October 2022

Biological Methods

Key words: Human spinal cord, Postmortem interval, Multicolor immunofluorescence, Horseradish, Peroxidase immunohistochemistry Neuronal markers

Organism: Human

Tissue: Spinal Cord

458
Interplay between Partial EMT and Cisplatin Resistance as the Drivers for Recurrence in HNSCC

J Ingruber, J Dudas, S Sprung, B Lungu, F Mungenast

Biomedicines (MDPI) Austria, Romania, 05 October 2022

Oncology

Key words: partial EMT, cisplatin resistance, StrataQuest, SCC-25 cells

Organism: Human

Tissue: Head and Neck

Pathological State: Cancer

459
Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions

Z Hasan, TQ Nguyen, BWS Lam, JHX Wong, CCY Wong, CKH Tan, VH Thiam, Y Zhang, V Angeli, LN Nguyen

Cellular and Molecular Life Sciences (Springer) Singapore, Bangladesh, 05 October 2022

Neuroscience

Key words: Sphingosine-1-phosphate, S1P transporters, S1P signaling, Neuroinflammation, Multiple sclerosis Lymphocyte egress

Organism: Mouse

Tissue: Brain, Spinal Cord

460
In-situ vaccination using dual responsive organelle targeted nanoreactors

V Sunil, A Mozhi, W Zhan, JH Teoh, PB Ghode, NV Thakor, CH Wang

Biomaterials (Elsevier) Singapore, UK, USA, 04 October 2022

Nanomedicine

Key words: In-situ vaccine, Dual-responsive, Backbone shattering, Combination therapy, Orthotopic glioblastoma mice model, Personalized medicine

Organism: Mouse

Tissue: Brain

Pathological State: Cancer

461
Heart-targeting exosomes from human cardiosphere-derived cells improve the therapeutic effect on cardiac hypertrophy

L Mao, YD Li, RL Chen, G Li, XX Zhou, F Song, C Wu, Y Hu, YX Hong, X Dang, GR Li, Y Wang

Journal of Nanobiotechnology (BMC) China, 04 October 2022

Nanomedicine

Key words: Genetic engineering, Exosomes, Heart homing peptide, Cardiosphere-derived cells, Cardiac hypertrophy

Organism: Rat

Tissue: Heart, Lung, Kidney

Pathological State: Cardiac hypertrophy

462
Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs

L Chen, Y Wang, J Lin, Z Song, Q Wang, W Zhao, Y Wang, X Xiu, Y Deng, X Li, Q Li, X Wang, J Li, X Liu, K Liu, J Zhou, K Li, Y Liu, S Liao, Q Deng, C Xu, Q Sun, S Wu, K Zhang, MX Guan, T Zhou, F Sun, X Cai, C Huang, G Shan

Nature Communications (Nature) China, 01 October 2022

Neuroscience

Key words: Neurophysiology, Non-coding RNAs, Reproductive biology, RNA transport

Organism: Mouse

Tissue: Brain

463
Gut–Brain Axis: Insights from Hippocampal Neurogenesis and Brain Tumor Development in a Mouse Model of Experimental Colitis Induced by Dextran Sodium Sulfate

R Vitali, C Prioreschi, L Lorenzo Rebenaque, E Colantoni, D Giovannini, S Frusciante, G Diretto, F Marco-Jiménez, M Mancuso, A Casciati, S Pazzaglia

International Journal of Molecular Sciences (MDPI) Italy, Spain, 29 September 2022

Developmental Biology

Key words: DSS-induced colitis, brain, neuroinflammation, adult hippocampal neurogenesis, metabolomics, medulloblastoma

Organism: Mouse

Tissue: Brain, Colon

Pathological State: Colitis

464
BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation

CK Wu, MT Wei, HC Wu, CL Wu, CJ Wu, H Liaw, WP Su

Scientific reports (Nature) Taiwan, 29 September 2022

Oncology

Key words: Cancer, Lung cancer, Non-small-cell lung cancer, Oncology

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

465
A novel ceRNA regulatory network involving the long noncoding NEAT1, miRNA-466f-3p and its mRNA target in osteoblast autophagy and osteoporosis

X Zhao, D Zhao, B Geng, W Yaobin, Y Xia

Journal of Molecular Medicine (Springer) China, 28 September 2022

Osteology

Key words: LncRNA NEAT1, MiRNA-466f-3p, HK2, Autophagy, Osteoblast

Organism: Mouse

Tissue: Bone

466
Assessment of traditional Chinese medicine pattern in a bleomycin-induced pulmonary fibrosis mouse model: A pilot study

X Gu, W Wei, Z Liu, F Cao, Z Wu, J Xie, T Wang, Y Jiao

Journal of Traditional Chinese Medical Sciences (Elsevier) China, 28 September 2022

Pulmonology

Key words: Bleomycin, Idiopathic pulmonary fibrosis, Pattern characteristics, Tongue image, Fibrinolytic factor, Inflammatory factor

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary fibrosis

467
Tick feeding modulates the human skin immune landscape to facilitate tick-borne pathogen transmission

J Strobl, V Muendler, S Müller, A Gindl, S Berent, AM Schötta, L Kleissl, C Staud, A Redl, L Unterluggauer, AE Aguilar González, ST Weninger, D Atzmüller, R Klasinc, G Stanek, M Markowicz, H Stockinger, G Stary

The Journal of Clinical Investigation (American Society of Clinical Investigation) Austria, 27 September 2022

Parasitology

Organism: Human

Tissue: Skin

468
Dynamic Changes in the NK-, Neutrophil-, and B-cell Immunophenotypes Relevant in High Metastatic Risk Post Neoadjuvant Chemotherapy–Resistant Early Breast Cancers

P Gazinska, C Milton, J Iacovacci, J Ward, R Buus, T Alaguthurai, R Graham, A Akarca, E Lips, K Naidoo, J Wesseling, T Marafioti, M Cheang, C Gillett, Y Wu, A Khan, A Melcher, R Salgado, M Dowsett, A Tutt, I Roxanis, S Haider, S Irshad

Clinical Cancer Research (AACR Publications) UK, The Netherlands, Australia, Belgium, 26 September 2022

Oncology, Immunology

Organism: Human

Tissue: Breast

Pathological State: Cancer

469
Azelnidipine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by targeting MEK1/2

L Zhao, Y Zhang, A Li, X Lu, M Li, Q Yuan, N Yang, X Zhao, X Li, Y Jiang, K Liu

Molecular Therapy Oncolytics (Elsevier) China, 26 September 2022

Oncology

Key words: Esophageal squamous cell carcinoma, Azelnidipine, Proliferation, Cell cycle, MEK1/2 inhibitor, MEK1/2-ERK1/2 signaling pathway

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

470
Correlation analysis of tumor purity with clinicopathological, molecular, and imaging features in high-grade gliomas

Q Zhou, P Zhang, J Man, B Zhang, C Xue, X Ke, J Zhou

Neurosurgical Review (Springer) China, 26 September 2022

Oncology, Medical Image Analysis

Key words: High-grade gliomas, Tumor purity, Tumor microenvironment, Neuroimaging

Organism: Human

Tissue: Brain

Pathological State: Cancer

471
Microcystin-leucine-arginine affects brain gene expression programs and behaviors of offspring through paternal epigenetic information

J Xu, W Zhang, S Zhong, X Xie, H Che, W Si, X Tuo, D Xu, S Zhao

Science of The Total Environment (Elsevier) China, 24 September 2022

Developmental Biology

Key words: Paternal epigenetic inheritance, Neurodevelopment in offspring, DNA methylation, Microcystin-LR, Cross-generational effects

Organism: Zebrafish

Tissue: Testis

472
Lithium Treatment Improves Cardiac Dysfunction in Rats Deprived of Rapid Eye Movement Sleep

PH Chen, CC Chung, SH Liu, YH Kao, YJ Chen

International Journal of Molecular Sciences (MDPI) Taiwan, 23 September 2022

Cardiology

Key words: rapid eye movement sleep deprivation, lithium, antifibrosis, cardioprotection

Organism: Rat

Tissue: Heart

Pathological State: Cardiac fibrosis

473
Truncation mutations in MYRF underlie primary angle closure glaucoma

J Ouyang, W Sun, H Shen, X Liu, Y Wu, H Jiang, X Li, Y Wang, Y Jiang, X Xiao, JF Hejtmancik

Human Genetics (Springer) China, USA, 21 September 2022

Ophthalmology

Organism: Mouse

Tissue: Eye

474
Lenvatinib synergistically promotes radiotherapy in hepatocellular carcinoma by inhibiting Src/STAT3/NF-κB-mediated epithelial–mesenchymal transition and metastasis

YS Weng, IT Chiang, JJ Tsai, YC Liu, FT Hsu

International Journal of Radiation Oncology*Biology*Physics (Elsevier) Taiwan, 19 September 2022

Oncology, Radiotherapy

Key words: Radiotherapy, lenvatinib, Src, epithelial–mesenchymal transition, hepatocellular carcinoma

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

475
Phosphorus fractions and iron oxides responsible for the variations in the Cd retention capacity in tropical soil aggregates under different cropping patterns

D Wei, C Wei, P Pan, B Lin, L Wu, B Liu, Z He

Journal of Hazardous Materials (Elsevier) China, USA, 19 September 2022

Ecology

Key words: Cadmium, Tropical soil aggregates, Adsorption characteristics, P fractions, Fe oxides

Cell Line: Soil samples

476
FDX1 expression predicts favourable prognosis in clear cell renal cell carcinoma identified by bioinformatics and tissue microarray analysis

X Huang, T Wang, J Ye, H Feng, X Zhang, X Ma, B Wang, Y Huang, X Zhang

Frontiers in Genetics (Frontiers Media S.A.) China, 16 September 2022

Oncology

Key words: ferredoxin 1, clear cell renal cell carcinoma, cuproptosis, metastasis, tumourigenesis, tissue microarray analyses, prognostic biomarker

Organism: Human

Tissue: Kidney

Pathological State: Cancer

477
A neurogenic signature involving monoamine Oxidase-A controls human thermogenic adipose tissue development

J Solivan-Rivera, ZY Loureiro, T DeSouza, A Desai, S Pallat, Q Yang, R Rojas-Rodriguez, R Ziegler, P Skritakis, S Joyce, D Zhong, T Nguyen, S Corvera

Elife (eLife Sciences Publications) USA, 15 September 2022

Developmental Biology

Organism: Human

Tissue: Adipose Tissue

478
Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells

G Zou, J Xia, H Luo, D Xiao, J Jin, C Miao, X Zuo, Q Gao, Z Zhang, T Xue, Y You, Y Zhang, W Xiong

Nature Metabolism (Nature) China, USA, 15 September 2022

Neuroscience, Toxicology

Key words: Cerebellum, Ion channels in the nervous system, Metabolism, Neurophysiologym

Organism: Mouse

Tissue: Brain

479
Penicillium digitatum, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient

I Iturrieta-González, A Giacaman, P Godoy-Martínez, F Vega, M Sepúlveda, C Santos, V Toledo, G Rivera, L Ortega, A San Martín, V Bahamondes, F Collao, R Sánchez, F Fonseca-Salamanca

Journal of Fungi (MDPI) Chile, 14 September 2022

SARS-CoV-2, Immunology

Key words: Penicillium digitatum, COVID-19, pulmonar infection, pneumonia

Cell Line: Penicillium digitatum fungal culture

480
Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren's syndrome

N Kaneko, H Chen, CA Perugino, T Maehara, R Munemura, S Yokomizo, J Sameshima, TJ Diefenbach, KR Premo, A Chinju, Y Miyahara, M Sakamoto, M Moriyama, JH Stone, S Nakamura, S Pillai

Scientific Reports (Nature) USA, Japan, 14 September 2022

Immunology, Rheumatology

Key words: Diseases, Immunology, Pathogenesis, Rheumatology

Organism: Human

Tissue: Salivary Gland

Pathological State: Sjögren's syndrome

481
ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model

YY Wang, AC Hung, YC Wu, S Lo, HD Chen, YK Chen, YC Hsieh, SCS Hu, MF Hou, SSF Yuan

Scientific Reports (Springer) Taiwan, UK, 14 September 2022

Oncology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

482
Ultrasmall zirconium carbide nanodots for synergistic photothermal-radiotherapy of glioma

M Yin, X Chen, Q Guo, L Xiao, P Gao, D Zang, J Dong, Z Zha, X Dai, X Wang

Nanoscale (Royal Society of Chemistry) China, 13 September 2022

Nanomedicine, Radiotherapy

483
Visualization of macrophage subsets in the development of the fetal human inner ear

C Steinacher, LJ Chacko, Wei Liu, H Rask-Andersen, W Bader, J Dudas, CM Sergi, T Dhanaseelan, N Moreno, R Glueckert, R Hoermann, A Schrott-Fischer

Frontiers in Immunology (Frontiers Media S.A.) Austria, Sweden, Canada, UK, 09 September 2022

Developmental Biology

Key words: fetal human inner ear, macrophages, development, IBA-1, CD45, CD68, CD163, CX3CL1

Organism: Human

Tissue: Embryo

484
In utero arsenic exposure increases DNA damage and gene expression changes in umbilical cord mesenchymal stem cells (UC-MSCs) from newborns as well as in UC-MSC differentiated hepatocytes

S Kantisin, K Chaisatra, P Hunsonti, V Parnlob, P Navasumrit, M Ruchirawat

Toxicology Reports (Elsevier) Thailand, 07 September 2022

Toxicology, Reproductive Medicine

Key words: Arsenic, In utero exposure, 8-OHdG, 8-nitroguanine, Mesenchymal stem cells

Cell Line: Human mesenchymal stem cells

485
Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial.

OL Filip, AG Mocanu, IA Neacsu, MV Ciocilteu, G Rau, J Neamtu

Current Health Sciences Journal (EBSCO) Romania, 05 September 2022

Tissue Engineering

Tissue: Collagen Matrix

486
Interleukin-4 receptor alpha signaling regulates monocyte homeostasis.

P Haider, JB Kral-Pointner, M Salzmann, F Moik, S Bleichert, WC Schrottmaier, C Kaun, M Brekalo, MB Fischer, WS Speidl, C Hengstenberg, BK Podesser, K Huber, I Pabinger, S Knapp, F Brombacher, C Brostjan

The FASEB Journal (Wiley) Austria, 05 September 2022

Immunology

Key words: homeostasis, immunity, innate, interleukin-4, monocytes, receptors, signal transduction

Organism: Mouse

Tissue: Spleen

487
Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection

N Vaquero-Siguero, N Schleussner, J Volk, M Mastel, J Meier, R Jackstadt

Cancers (MDPI) Germany, 31 August 2022

Oncology

Key words: colorectal cancer, metastasis, mouse models, mouse-derived organoids, orthotopic transplantation, tumor heterogeneity, clonal selection, niche

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

488
PPsNet: An Improved Deep Learning Model for Microsatellite Instability High Prediction in Colorectal Cancer from Whole Slide Images

J Lou, J Xu, Y Zhang, Y Sun, A Fang, J Liu, LAJ Mur, B Ji

Computer Methods and Programs in Biomedicine (Elsevier) China, UK, 31 August 2022

Medical Image Analysis

Key words: Colorectal cancer, Microsatellite instability, Deep learning, Deep supervision, Pair-wise learning, Synergic network, Parameter sharing, Whole slide images

Organism: Human

Tissue: Colon

Pathological State: Cancer

489
Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

SJF Cronin, S Rao, MA Tejada, BL Turnes, S Licht-Mayer, T Omura, C Brenneis, E Jacobs, L Barrett, A Latremoliere, N Andrews, KM Channon, A Latini, AC Arvanites, LS Davidow, M Costigan, LL Rubin, JM Penninger, CJ Woolf

Science Translational Medicine (Science) Austria, USA, UK, Brazil, 31 August 2022

Pharmacology, Oncology

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

490
Identification and validation of a poor clinical outcome subtype of primary prostate cancer with Midkine abundance

Q Zhou, C Yang, Z Mou, S Wu, X Dai, X Chen, Y Ou, L Zhang, J Sha, H Jiang

Cancer Science (Wiley) China, 26 August 2022

Oncology

Organism: Human

Tissue: Prostate

Pathological State: Cancer

491
P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma

V Arnaud-Sampaio, C Bento, T Glaser, E Adinolfi, H Ulrich, C Lameu

Frontiers in Oncology (Frontiers Media S.A.) Brazil, Italy, 25 August 2022

Pharmacology, Oncology

Key words: P2X7 receptor isoforms, chemoresistance, childhood cancer, cancer, drug efflux, cancer stem cells, autophagy, epithelial-mesenchymal transition

Cell Line: ACN human neuroblastoma cells

492
KI Essence extract (a spleen-tonifying formula) promotes neurite outgrowth, alleviates oxidative stress and hypomyelination, and modulates microbiome in maternal immune activation offspring

GA Lee, HW Zhao, YW Chang, CJ Lee, YSH Yang, YC Wu, WL Lin, YR Liu, DS Ning, SH Tseng

Frontiers in Pharmacology (Frontiers Media S.A.) Taiwan, 25 August 2022

Pharmacology

Key words: mushroom, maternal immune activation, myelination, microbiota, oxidative stress, spleen-tonifying formula

Organism: Rat

Tissue: Brain

493
Thymidine and 2′-deoxyuridine reduce microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35 induced brain injury

M Liu, M Zeng, S Wang, B Cao, P Guo, Y Zhang, J Jia, Q Zhang, B Zhang, R Wang, J Li, X Zheng, W Feng

Archives of Biochemistry and Biophysics (Elsevier) China, 24 August 2022

Neuroscience

Key words: Thymidine, 2′-deoxyuridine, Glycolytic metabolism, Microglia activation, Oxidative stress, Brain injury

Organism: Mouse

Tissue: Brain

Pathological State: Aβ25-35-induced brain injury

494
Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC.

K Li, Y Gong, D Qiu, H Tang, J Zhang, Z Yuan, Y Huang, Y Qin, L Ye, Y Yang

Journal for ImmunoTherapy of Cancer (BMJ Journals) China, 24 August 2022

Oncology

Key words: Immunity, Innate, Immunotherapy, Liver Neoplasms, Lymphocytes, Tumor-Infiltrating, Tumor Microenvironment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

495
The medial wall and medial compartment of the cavernous sinus: an anatomic study using plastinated histological sections

K Shi, Z Li, X Wu, C Ma, X Zhu, L Xu, Z Sun, S Xu, L Liang

Neurosurgical Review (Springer) China, 19 August 2022

Anatomy

Key words: Cavernous sinus, Medial wall, Dura mater, Plastination

Organism: Human

Tissue: Bone

496
Comparing different surface modifications of zinc oxide nanoparticles in the developmental toxicity of zebrafish embryos and larvae

ZY Chen, YC Yang, BJ Wang, FY Cheng, YL Lee, YH Lee, YJ Wang

Ecotoxicology and Environmental Safety (Elsevier) Taiwan, 17 August 2022

Toxicology, Zoology

Key words: Zinc oxide nanoparticles (ZnONPs, Danio rerio, Surface modification, Liver toxicity, Developmental changes, Autophagy

Organism: Zebrafish

Tissue: Embryo

497
TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma

S Hu, H Lu, W Xie, D Wang, Z Shan, X Xing, XM Wang, J Fang, W Dong, W Dai, J Guo, Y Zhang, S Wen, XY Guo, Q Chen, F Bai, Z Wang

The Journal of Clinical Investigation (American Society for Clinical Investigation) China, 16 August 2022

Oncology, Immunology

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

498
Papillary Renal Neoplasm with Reverse Polarity—a Comparative Study with CCPRCC, OPRCC, and PRCC1

T Wang, X Ding, X Huang, J Ye, H Li, S Cao, Y Gao, X Ma, Q Huang, B Wang

Human Pathology (Elsevier) China, 14 August 2022

Nephrology

Key words: Papillary renal neoplasm with reverse polarity, Papillary renal cell carcinoma type 1, Clear cell papillary renal cell carcinoma, Oncocytic papillary renal cell carcinoma, Whole exon sequencing, KRAS

Organism: Human

Tissue: Kidney

Pathological State: Cancer

499
Comparison of H7N9 and H9N2 influenza infections in mouse model unravels the importance of early innate immune response in host protection

C Zhu, M Zhang, Y He, Y Yang, L Zhang, S Zuan, L Jiang, J Xu, X Zhang

Frontiers in Cellular and Infection Microbiology (Frontiers Media S.A.) China, 12 August 2022

Virology, Immunology

Key words: H7N9, H9N2, pathological characteristics, C57BL/6 mice, lung

Organism: Mouse

Tissue: Lung

Pathological State: Influenza Infection

500
Stereotaxic atlas of the infant rat brain at postnatal days 7–13

YN Chen, X Zheng, HL Chen, JX Gao, XX Li, JF Xie, YP Xie, K Spruyt, YF Shao, YP Hou

Frontiers in Neuroanatomy (Frontiers Media S.A.) China, France, 12 August 2022

Neuroscience, Developmental Biology

Key words: infant rat, brain, atlas, stereotaxic coordinates, neural development

Organism: Rat

Tissue: Brain

501
Short-Term Cortical Electrical Stimulation during the Acute Stage of Traumatic Brain Injury Improves Functional Recovery

LC Wang, WY Wei, PC Ho

Biomedicines (MDPI) Taiwan, 12 August 2022

Neuroscience

Key words: traumatic brain injury, neural stem cells, cortical electrical stimulation, functional recovery

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

502
Preclinical Therapeutic Evaluation of Lenvatinib-Eluting Microspheres for Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

J Pe, B Choi, H Choi, SW Kwon, DH Kim

CardioVascular and Interventional Radiology (Springer) USA, 12 August 2022

Oncology

Key words: Transcatheter arterial chemoembolization, Hepatocellular carcinoma, Lenvatinibm, Drug eluting microspheres, Local drug delivery

Organism: Rat

Tissue: Lung, Heart, Kidney

Pathological State: Cancer

503
Effects of Cordyceps militaris fermentation products on reproductive development in juvenile male mice

S Lin, WK Hsu, MS Tsai, TH Hsu, TC Lin, HL Su, SH Wang, D Jin

Scientific Reports (Nature) China, Taiwan, 12 August 2022

Nutritional science

Key words: Nutrition, Quality of life

Organism: Mouse

Tissue: Testis

504
m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs

F Niu, P Che, Z Yang, J Zhang, L Yang, M Zhuang, X Ou, SJ Ji

iScience (Cell Press) China, 11 August 2022

Ophthalmology

Key words: m6A, YTHDF1, YTHDF2, YTHDF3, Cortical neurogenesis, Retinal neurogenesis

Organism: Mouse

Tissue: Embryo

505
Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice

P Guo, M Zeng, B Cao, M Liu, Y Zhang, J Jia, Q Zhang, B Zhang, R Wang, W Xiong, X Zheng, W Feng

Journal of Functional Foods (Elsevier) China, 11 August 2022

Gastroenterology

Key words: Alzheimer's disease, Camellia oil, Gut microbiota, Lipid metabolism, PPARs

Organism: Mouse

Tissue: Brain

506
Disulfiram increases the efficacy of 5-fluorouracil in organotypic cultures of colorectal carcinoma

M Hendrych, K Říhová, B Adamová, V Hradil, M Stiborek, P Vlček, M Hermanová, J Vašíčková, P Beneš, J Šmarda, V Kanický, J Preisler, J Navrátilová

Biomedicine & Pharmacotherapy (Elsevier) Czech Republic, 10 August 2022

Oncology

Key words: Disulfiram/copper, 5-fluorouracil, Synergism, Organotypic culture, Spheroid, Colorectal carcinoma

Organism: Spheroid

Cell Line: HT-29 and HCT-116 human adenocarcinoma cells

507
Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus

M Sangesland, AT de la Peña, S Boyoglu-Barnum, L Ronsard, F Amokrane Nait Mohamed, T Bracamonte Moreno, RM Barnes, N Lonberg, M Ghebremichael, M Kanekiyo, A Ward, D Lingwood

Immunity (Cell Press) USA, 10 August 2022

Immunology

Key words: influenza virus, universal, B cell, vaccine, broad, antibody gene polymorphism, autoreactivityt, olerance

Cell Line: Hep2 cell

508
Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma

H Zhang, N Zhang, W Wu, Z Wang, Z Dai, X Liang, L Zhang, Y Peng, P Luo, J Zhang, Z Liu, Q Cheng, Z Liu

iScience (Cell Press) China, 10 August 2022

Oncology, Immunology

Key words: Immunology, Biocomputational method, Genomic analysis, Cancer

Organism: Human

Tissue: Brain

Pathological State: Cancer

509
Club cells employ regeneration mechanisms during lung tumorigenesis

Y Chen, R Toth, S Chocarro, D Weichenhan, J Hey, P Lutsik, S Sawall, GT Stathopulos, C Plass, R Sotillo

Nature Communications (Nature) Germany, 05 August 2022

Oncology

Key words: Cancer models, Cancer stem cells, Lung cancer, Mechanisms of disease

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

510
Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest

C Li, Y Feng, Z Fu, J Deng, Y Gu, H Wang, X Wu, Z Huang, Y Zhu, Z Liu, M Huang, T Wang, S Hu, B Yao, Y Zeng, CJ Zhou, SDM Brown, Y Liu, A Vidal-Puig, Y Dong, Y Xu

Cell death Discovery (Nature) China, USA, UK, 02 August 2022

Cell Biology

Key words: Cell biology, Development

Organism: Mouse

Tissue: Testis

511
Alleviating experimental allergic eye disease by inhibiting pro-lymphangiogenic VEGFR3 signal

B Lou, W Wu, L Zeng, W Zhou, X Zhang, X Zhou, Z Liu, K Liu, X Gu, X Chen, Y Wang, Y Chen, X Gao, F Zhang

The Ocular Surface (Elsevier) China, 02 August 2022

Ophthalmology

Key words: Allergic eye disease, Lymphatics, Vegfr3, CD4+ T cell, Lymph node

Organism: Mouse

Tissue: Eye, Small Intestine

Pathological State: Allergy

512
Intermittent hilar occlusion attenuates or prevents renal ischaemia-reperfusion in mice

L Wang, C Peng, J Chen, H Li, Q Jiao, Z Zhang, L Wang, Q Yuan, B Wang, Y Huang, X Ma

Biomedicine & Pharmacotherapy (Elsevier) China, 01 August 2022

Nephrology

Key words: Partial nephrectomy, Ischaemia-reperfusion injury, Oxidative damage, Laboratory animal models

Organism: Mouse

Tissue: Kidney

Pathological State: Renal fibrosis

513
Sulfur mustard single-dose exposure triggers senescence in primary human dermal fibroblasts

G Horn, C Schäfers, H Thiermann, S Völkl, A Schmidt, S Rothmiller

Archives of Toxicology (Springer) Germany, 29 July 2022

Toxicology

Key words: Sulfur mustard, Senescence, Human dermal fibroblasts, Wound healing disorder

Cell Line: Human primary dermal fibroblasts

514
A Chinese medical nutrition therapy diet accompanied by intermittent energy restriction alleviates type 2 diabetes by enhancing pancreatic islet function and and regulating gut microbiota composition

W Luo, J Zhou, X Yang, R Wu, H Liu, H Shao, B Huang, X Kang, L Yang, D Liu

Food Research International (Elsevier) China, 28 July 2022

Gastroenterology, Endocrinology

Key words: Type 2 diabetes, Diet, Intermittent energy restriction, Chinese Medical Nutrition Therapy, Pancreatic islet function, Gut microbiota

Organism: Mouse

Tissue: Pancreas

515
A Natural Gas Fermentation Bacterial Meal (FeedKind®) as a Functional Alternative Ingredient for Fishmeal in Diet of Largemouth Bass, Micropterus salmoides

B Guo, X He, C Ge, M Xue, J Wang, M Longshaw, J Wang, X Liang

Antioxidants (MDPI) China, UK, 28 July 2022

Zoology

Key words: largemouth bass, methanotroph (Methylococcus capsulatus, Bath) bacteria meal (FeedKind®), growth performance, antioxidant capacity, intestinal health

Organism: Bass Fish

Tissue: Small Intestine

516
Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial

OL Filip, AG Mocanu, IA Neascsu, MV Ciocilteu, G Rau, J Neamtu

Current Health Sciences Journal (Medical University Publishing House Craiova) Romania, 28 July 2022

Biological Materials

Key words: Biocomposite, collagen-hydroxyapatite, biocompatibility

517
High Glucose Aggravates Retinal Endothelial Cell Dysfunction by Activating the RhoA/ROCK1/pMLC/Connexin43 Signaling Pathway

H Zhao, H Kong, W Wang, T Chen, Y Zhang, J Zhu, D Feng, Y Cui

Investigative Ophthalmology & Visual Science (ARVO Journals) China, 26 July 2022

Ophthalmology

Key words: diabetic retinopathy, retinal vascular endothelial cells, RhoA/ROCK1/pMLC signaling, ROCK inhibitor, connexin43

Organism: Mouse

Tissue: Eye

518
Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 Macrophages through PI3K/Akt/mTOR Signaling Pathway

T Zhang, Y Zhang, Z Yang, Y Jiang, L Sun, D Huang, M Tian, Y Shen, J Dang, J Hou, Y Ma

Pathogens and Global Health (Taylor & Francis) China, 25 July 2022

Immunology

Key words: Echinococcus multilocularis, glycolysis, macrophage polarization, protoscoleces, PI3K/Akt/mTOR

Organism: Human

Tissue: Liver

Pathological State: Echinococcus Infection

519
Tegaserod Maleate Suppresses the Growth of Gastric Cancer In Vivo and In Vitro by Targeting MEK1/2

Z Wang, Y Chen, X Li, Y Zhang, X Zhao, H Zhou, X Lu, L Zhao, Q Yuan, Y Shi, J Zhao, Z Dong, Y Jiang, K Liu

Cancers (MDPI) China, 23 July 2022

Oncology

Key words: gastric cancer, tegaserod maleate, MEK1, MEK2, chemoprevention

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

520
miR-429 negatively regulates the progression of hypoxia-induced retinal neovascularization by the HPSE-VEGF pathway

H Xu, B Yang, Z Ren, D Wu, A Hu, J Hu

Experimental Eye Research (Elsevier) China, 22 July 2022

Ophthalmology

Key words: Neovascularization, Heparanase, miR-429, Retinopathy, VEGF

Organism: Mouse

Tissue: Eye

521
Hexavalent chromium exposure induces intestinal barrier damage via activation of the NF-κB signaling pathway and NLRP3 inflammasome in ducks

C Xing, F Yang, J Shan, X Yi, F Ali, Y Zhu, C Wang, C Zhang, Y Zhuang, H Cao, G Hu

Frontiers in Immunology (Frontiers Media S.A.) China, Pakistan, 22 July 2022

Zoology

Key words: hexavalent chromium, intestinal barrier, NF-κB, NLRP3, duck

Organism: Duck

Tissue: Small Intestine

522
Autologous exosome facilitates load and target delivery of bioactive peptides to repair spinal cord injury

N Ran, W Li, R Zhang, C Lin, J Zhang, Z Wei, Z Li, Z Yuan, M Wang, B Fan, W Shen, X Li, H Zhou, X Yao, X Kong, S Feng

Bioactive Materials (Elsevier) China, 22 July 2022

Neuroscience

Key words: Spinal cord injury, Targeted repair, Autologous plasma exosome, Drug loading, Axon regeneration

Organism: Mouse

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

523
Rice co-expression network analysis identifies gene modules associated with agronomic traits

Y Zhang, E Han, Y Peng, Y Wang, Y Wang, Z Geng, Y Xu, H Geng, Y Qian, S Ma

Plant Physiology (Oxford Academic) China, 22 July 2022

Botany

Organism: Japonica rice

524
Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter's Trans-Formed DLBCL and Germinal Center B-Cells

B Uhl, KT Prochazka, K Pansy, K Wenzl, J Strobl, C Baumgartner, MM Szymra, JE Waha, A Wolf, PV Tomazic, E Steinbauer, M Steinwender, S Friedl, M Weniger, R Küppers, M Pichler, HT Grenix, G Stary, AG Ramsay, B Apollonio

International Journal of Molecular Sciences (MDPI) Austria, Germany, 17 July 2022

Oncology

Key words: diffuse large B-cell lymphoma, Richter syndrome, transformed follicular lymphoma, chemokine receptors, CCR7, CCL19, CCL21

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

525
MiRNA-Mediated Fibrosis in the Out-of-Target Heart following Partial-Body Irradiation

B Tanno, F Novelli, S Leonardi, C Merla, G Babini, P Giardullo, M Kadhim, D Traynor, DKR Medipally, AD Meade, FM Lyng, S Tapio, L Marchetti, A Saran, S Pazzaglia, M Mancuso

Cancers (MDPI) Italy, UK, Ireland, Germany, 16 July 2022

Cardiology

Key words: miRNome, Raman spectroscopy, abscopal effect, cardiac fibrosis, miR-1, mir-133a

Organism: Mouse

Tissue: Heart

526
LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer

Z Sun, R Zhang, X Zhang, Y Sun, P Liu, N Francoeur, L Han, WY Lam, Z Yi, R Sebra, M Walsh, J Yu, W Zhang

Molecular Cancer (Springer) USA, China, 16 July 2022

Oncology

Key words: LINE-1, Transposable element, NSCLC, LUSC, LUAD, FGGY, Metabolic

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

527
Suppression of Allergic Asthma by Loss of Function of Miz1-Mediated Th1 Skewing

HC Do-Umehara, C Chen, Q Zhang, RP Schleimer, GRS Budinger, J Liu

American Journal of Respiratory Cell and Molecular Biology (ATS Journals) USA, 14 July 2022

Allergy Research

Key words: Asthma, Gene regulation, Th1/Th2 immunity, Miz1, IL-12

528
The prostate tissue‐based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy

CM Heaphy, CE Joshu, JR Barber, C Davis, J Lu, R Zarinshenas, E Giovannucci, LA Mucci, MJ Stampfer, M Han, AM De Marzo, TL Lotan, EA Platz, AK Meeker

The Journal of Pathology: Clinical Research (Wiley) USA, 14 July 2022

Oncology

Organism: Human

Tissue: Prostate

Pathological State: Cancer

529
Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice

YC Shyu, PC Liao, TS Huang, CJ Yang, MJ Lu, SM Huang, XY Lin, CC Liou, YH Kao, CH Lu, HL Peng, JR Chen, WJ Cherng, NI Yang, YC Chen, HC Pan, ST Jiang, CC Hsu, G Lin, SS Yuan, PWC Hsu, KJ Wu, TL Lee, CKJ She

Advanced Science (Wiley) Taiwan, 13 July 2022

Aging

Organism: Mouse

Tissue: Heart

Pathological State: Tissue Fibrosis

530
Single-cell profiling of immune cells after neoadjuvant pembrolizumab and chemotherapy in IIIA non-small cell lung cancer (NSCLC)

Z Hui, J Zhang, Y Ren, X Li, C Yan, W Yu, T Wang, S Xiao, Y Chen, R Zhang, F Wei, J You, X Ren

Cell Death & Disease (Nature) China, 13 July 2022

Oncology

Key words: Cancer immunotherapy, Cancer microenvironment, Non-small-cell lung cancer

Organism: Human

Tissue: Lung

Pathological State: Cancer

531
The Interplay of NEAT1 and miR-339-5p Influences on Mesangial Gene Expression and Function in Various Diabetic-Associated Injury Models

S Reichelt-Wurm, M Pregler, T Wirtz, M Kretz, K Holler, B Banas, MC Banas

Non-Coding RNA (MDPI) Germany, 13 July 2022

Endocrinology, Genetics

Key words: NEAT1, has-miR-339-5p, diabetic kidney disease, mesangial cell, lncRNA, miRNA

Cell Line: Human mesangial cells

532
Pharmacologic modulation of intracellular Na+ concentration with ranolazine impacts inflammatory response in humans and mice

M Lenz, M Salzmann, CI Ciotu, C Kaun, KA Krychtiuk, A Rehberger Likozar, M Sebestjen, L Goederle, S Rauscher, Z Krivaja, CJ Binder, K Huber, C Hengstenberg, BK Podesser, MJM Fischer, J Wojta, PJ Hohensinner, WS Speidl

PNAS (United States National Academy of Sciences) Austria, Slovenia, 13 July 2022

Immunology

Key words: Inflammation, Atherosclerosis, Endothelium, NF-κB, Ranolazine

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Atherosclerotic plaques

533
CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection

OO Baiyegunhi, J Mann, T Khaba, T Nkosi, Anele Mbatha, F Ogunshola, C Chasara, N Ismail, T Ngubane, I Jajbhay, J Pansegrouw, KL Dong, BD Walker, T Ndung'u, ZM Ndhlovu

Nature Communications (Nature) South Africa, USA, Germany, UK, 12 July 2022

Immunology, Virology

Key words: HIV infections, Lymph node, Retrovirus

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

534
Angiotensin-Converting Enzyme 2 Potentiates SARS-CoV-2 Infection by Antagonizing Type I Interferon Induction and Its Down-Stream Signaling Pathway

J Chen, J Liu, Z Chen, H Peng, C Zhu, D Feng, S Zhang, P Zhao, X Zhang, J Xu

mSphere (ASM Journals) China, 12 July 2022

Immunology, SARS-CoV-2

Pathological State: Covid-19

Cell Line: A549, HEK293T, NCI-H1299, and Vero E6 cell lines

535
MicroRNA-21-5p promotes mucosal type 2 inflammation via regulating GLP1R/IL-33 signaling in chronic rhinosinusitis with nasal polyps

G Luan, M Wang, J Yuan, X Bu, Y Wang, S Ying, C Wang, L Zhang

Journal of Allergy and Clinical Immunology (Elsevier) China, 11 July 2022

Allergy Research

Key words: Chronic rhinosinusitis with nasal polyps, Glucagon-like peptide-1 receptor, MicroRNA-21-5p, Type 2 inflammation

Organism: Human

Tissue: Mucosa

Pathological State: chronic rhinosinusitis

536
Molecular species of oxidized phospholipids in brain differentiate between learning-and memory impaired and unimpaired aged rats

MS Narzt, C Kremslehner, B Golabi, IM Nagelreiter, J Malikovic, AM Hussein, R Plasenzotti, V Korz, G Lubec, F Gruber, J Lubec

Amino Acids (Springer) Austria, Egypt, 11 July 2022

Neuroscience

Key words: Prefrontal cortex, Memory, Phospholipids, Learning

Organism: Rat

Tissue: Brain

537
The immune microenvironment features and response to immunotherapy in EBV-associated lymphoepithelioma-like cholangiocarcinoma

NJ Chiang, YC Hou, KT Tan, HW Tsai, YJ Lin, YC Yeh, LT Chen, YF Hou, MH Chen, YS Shan

Hepatology International (Springer) Taiwan, 03 July 2022

Hepathology

Key words: Intrahepatic cholangiocarcinoma, Epstein–Barr virus, Lymphoepithelioma-like cholangiocarcinoma, Tumor immune microenvironment, Adaptive immune response, T cells, Macrophages, PD-1, PD-L1, Immune checkpoint blockade

Organism: Human

Tissue: Liver

Pathological State: Cancer

538
The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes

B Mahlobo, F Laher, W Smidt, F Ogunshola, T Khaba, T Nkosi, A Mbatha, T Ngubane, K Dong, I Jajbhay, J Pansegrouw, ZM Ndhlovu

BMC Immunology (BMC) South Africa, USA, 01 July 2022

Immunology

Key words: Follicular regulatory T cells (TFRs), Follicular helper T (TFH) cells, Lymph node, Biomarkers, HIV

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: HIV Infection

539
Mutations in GCK May Lead to MODY2 by Reducing Glycogen Synthesis

Z Li, K Li, Y Sun, X Jiang, J Liu, J Li, L Fang, G Li, Q Guan, C Xu

Advanced Biology (Wiley) China, 30 June 2022

Endocrinology

Cell Line: HepG2 cells

540
An optimized method for obtaining clinical‐grade specific cell subpopulations from human umbilical cord‐derived mesenchymal stem cells

Y Jia, A Wang, B Zhao, C Wang, R Su, B Zhang, Z Fan, Q Zeng, L He, X Pei, W Yue

Cell Proliferation (Wiley) China, 29 June 2022

Biological Methods

Organism: Human

Cell Line: hUC-MSCs

541
The long-term survival and functional maturation of human iNPC-derived neurons in the basal forebrain of cynomolgus monkeys

S Feng, T Zhang, W Ke, Y Xiao, Z Guo, C Lu, S Li, Z Guo, Y Liu, G Tan, Y Chen, F Yue, Y Shu, C Yue, N Jing

Life Medicine (Oxford Academic) China, 28 June 2022

Stem Cell Research, Neuroscience

Key words: Non-human primates, Cerebral cell transplantation, Human induced neural stem/progenitor cells, Neuronal differentiation, Functional maturation

Organism: Cynomolgus Monkey

Tissue: Brain

542
Hepatitis B virus X gene impacts on the innate immunity and immune‐tolerant phase in chronic hepatitis B virus infection

KC Chang, HH Chua, YH Chen, DJ Tsuei, MH Lee, CL Chiang, YM Jeng, JF Wu, HL Chen, HY Hsu, YH Ni, MH Chang

Liver International (Wiley) Taiwan, 28 June 2022

Hepathology, Immunology

Organism: Human

Tissue: Liver

Pathological State: Chronic hepatitis B

543
Cancer-Associated Fibroblasts Promote Tumor Aggressiveness in Head and Neck Cancer through Chemokine Ligand 11 and CC Motif Chemokine Receptor 3 Signaling Circuit

WY Huang, YS Lin, YC Lin, S Nieh, YM Chang, TY Lee, SF Chen, KD Yang

Cancers (MDPI) Taiwan, 27 June 2022

Oncology

Key words: head and neck cancer, cancer-associated fibroblasts, CCL11, CCR3, tumor microenvironment

Pathological State: Cancer

Cell Line: FaDu cell lines (HTB-43 - ATCC)

544
Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure

R Zhang, S Chen, L Chen, L Ye, Y Jiang, H Peng, Z Guo, M Li, X Jiang, P Guo, D Yu, R Zhang, Y Niu, Y Zhuang, M Aschner, Y Zheng, D Li, W Chen

Particle and Fibre Toxicology (BMC) China, USA, 23 June 2022

Pulmonology

Key words: Particle matter, Chronic lung injuries, Single-cell RNA sequencing, IL-17A, Myeloid-derived suppressor cells

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

545
Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment

TY Wu, M Chen, IC Chen, YJ Chen, CY Chen, CH Wang, JJ Cheng, K Nepali, KH Chuang, JP Liou

Journal of Advanced Research (Elsevier) Taiwan, 22 June 2022

Oncology, Pharmacology

Key words: Cancer, Drug design, HDAC6/HSP90 dual inhibitor, Immunosensitizer, Tumor microenvironment

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

546
PLSCR1 promotes apoptosis and clearance of retinal ganglion cells in glaucoma pathogenesis

J Luo, Q Lian, D Zhu, M Zhao, T Mei, B Shang, Z Yang, C Liu, W Xu, L Zhou, K Wu, X Liu, Y Lai, F Mao, W Li, C Zuo, K Zhang, M Lin, Y Zhou, Y Liu, L Lu, L Zhao

Genes & Diseases (Elsevier) China, 21 June 2022

Ophthalmology

Key words: Apoptosis, Glaucoma, Phagocytosis, PLSCR1, Retinal ganglion cells

Organism: Mouse

Tissue: Eye

Pathological State: Glaucoma

547
A diagnostic pitfall; small cell carcinoma-like features in basaloid squamous cell carcinoma of the esophagus

H Ishida, A Kasajima, T Yamauchi, R Akaishi, S Ueaki, Y Taniyama, F Fujishima, T Koike, T Kamei, AKY Lam, H Sasano

Histology and Histopathology (Griffith University) Japan, Australia, Germany, 21 June 2022

Oncology

Key words: esophagus, biopsy, basaloid squamous cell carcinoma, small cell carcinoma, diagnostic pitfall

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

548
Microtube Array Membrane Encapsulated Cell Therapy: A Novel Platform Technology Solution for Treatment of Alzheimer's Disease

SM Chen, TC Hsu, CH Chew, WT Huang, AL Chen, YF Lin, S Eddarkaoui, L Buee, CC Chen

International Journal of Molecular Sciences (MDPI) Taiwan, USA, France, 20 June 2022

Neuroscience, Pharmacology

Key words: neurodegenerative disease, Alzheimer's disease (AD), passive immunotherapy, encapsulated cell therapy, microtube array membrane (MTAMs)

Organism: Mouse

Tissue: Brain

Pathological State: Alzheimer's Disease

549
Clinical value of urinary cytokines/chemokines as prognostic markers in patients with crescentic glomerulonephritis

J Jeon, J Park, HJ Boo, KE Yang, CJ Lee, JE Lee, K Kim, GY Kwon, W Huh, DJ Kim, HR Jang

Scientific reports (Nature) South Korea, 17 June 2022

Nephrology

Key words: Chemokines, Cytokines, Kidney diseases

Organism: Human

Tissue: Kidney

Pathological State: Crescentic Glomerulonephritis

550
Decreased CD11c‐positive dendritic cells in the tumor microenvironment predict double‐hit/triple‐hit genotype and survival in diffuse large B‐cell lymphoma

CT Yuan, SS Chuang, PY Cheng, K Chang, H Wang, JH Tsai, JY Liau, WC Chou

The Journal of Pathology: Clinical Research (Wiley) Taiwan, 17 June 2022

Oncology

Key words: high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, double-hit lymphoma, triple-hit lymphoma, diffuse large B-cell lymphoma, tumor microenvironment, dendritic cell, decision curve analysis

Organism: Human

Tissue: Lymphoid Tissue

Pathological State: Cancer

551
Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF‐κB pathway

Y Li, Q Zhuang, L Tao, K Zheng, S Chen, Y Yang, C Feng, Z Wang, H Shi, J Shi, Y Fang, L Xiao, D Geng, Z Wang

Cell Proliferation (Wiley) China, 16 June 2022

Osteology

Organism: Mouse

Tissue: Bone

Pathological State: Osteoporosis

552
Evaluation of Topical and Subconjunctival Injection of Hyaluronic Acid-Coated Nanoparticles for Drug Delivery to Posterior Eye

CH Tsai, LN Hoang, CC Lin, LC Pan, CL Wu, IC Lin, PY Wang, CL Tseng

Pharmaceutics (MDPI) Taiwan, China, 13 June 2022

Nanomedicine

Key words: posterior eye, hyaluronic acid, surface charges, nanoparticles, drug delivery, eyedrops, subconjunctival injection, retina

Organism: Mouse

Tissue: Eye

553
Occurrence of Lymphangiogenesis in Peripheral Nerve Autografts Contrasts Schwann Cell-Induced Apoptosis of Lymphatic Endothelial Cells In Vitro

C Hromada, J Hartmann, J Oesterreicher, A Stoiber, A Daerr, B Schädl, E Priglinger, AH Teuschl-Woller, W Holnthoner, J Heinzel, D Hercher

Biomolecules (MDPI) Austria, Germany, 12 June 2022

Neuroscience

Key words: peripheral nerve regeneration, lymphangiogenesis, Schwann cells, lymphatic endothelial cells

Cell Line: Fibrin hydrogels containing Schwann cell, lymphatic endothelial cells and adipose-derived stem cells

554
Accumulation of Cytotoxic Skin Resident Memory T Cells and Increased Expression of IL-15 in Lesional Skin of Polymorphic Light Eruption

VK Patra, J Strobl, D Atzmüller, B Reininger, L Kleissl, A Gruber-Wackernagel, JF Nicolas, G Stary, M Vocanson, P Wolf

Frontiers in Medicine (Frontiers Media S.A.) France, Austria, 10 June 2022

Dermatology, Allergy Research

Key words: sun allergy, polymorphic light eruption, disease recurrence, inflammation, disease memory, resident memory T cell (TrM)

Organism: Human

Tissue: Skin

Pathological State: Polymorphic light eruption (PLE)

555
A Fraction of CD8+ T Cells from Colorectal Liver Metastases Preferentially Repopulate Autologous Patient-Derived Xenograft Tumors as Tissue-Resident Memory T Cells

F Liang, LM Nilsson, F Byvald, A Rezapour, H Taflin, JA Nilsson, U Yrlid

Cancers (MDPI) Sweden, Australia, 10 June 2022

Oncology

Key words: colorectal liver metastases, tumor-infiltrating lymphocytes, tissue-resident memory T cells, patient-derived xenograft model, MEK inhibition

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

556
Long‐term outcomes of arterial ischemia or venous occlusion on vascularized groin lymph nodes in a rat model

CY Yang, IE Tinhofer, MH Cheng

Journal of Surgical Oncology (Wiley) Taiwan, Austria, 09 June 2022

Angiology

Key words: arterial ischemia, lymphedema, vascularized lymph node transfer, venous congestion

Organism: Rat

Tissue: Lymphoid Tissue

Pathological State: Arterial ischemia

557
Proteomic analysis of hepatic fibrosis induced by a high starch diet in largemouth bass (Micropterus salmoides)

X Wu, X Gu, M Xue, C Ge, X Liang

Comparative Biochemistry and Physiology Part D: Genomics and Proteomics (Elsevier) China, 08 June 2022

Zoology, Endocrinology

Key words: High starch diet, Hepatic fibrosis, Proteomics, PRM, Micropterus salmoides

Organism: Bass Fish

Tissue: Liver

Pathological State: Hepatic fibrosis

558
Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5

P Qiu, Y Jie, C Ma, H Chen, Y Qin, K Tu, L Wang, Z Zhang

Cell Death Discovery (Nature) China, 07 June 2022

Oncology

Key words: Cancer, Oncogenesis

Organism: Human

Tissue: Uterus

Pathological State: Cancer

559
Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses

X Cai, Z Zhou, J Zhu, X Liu, G Ouyang, J Wang, Z Li, X Li, H Zha, C Zhu, F Rong, J Tang, Q Liao, X Chen, W Xiao

Cell Reports (Cell Press) China, 07 June 2022

Immunology

Key words: OTUD3, RIG-I, MDA5, cGAS, deubiquitination, innate immunity

Organism: Mouse

Tissue: Lung

Pathological State: Virus Infection

560
Loss of core-fucosylation of SPARC impairs collagen binding and contributes to COPD

TJ Wu, SH Wang, ESW Chen, HH Tsai, YC Chang, YH Tseng, J Yu

Cellular and Molecular Life Sciences (Springer) Taiwan, 07 June 2022

Pulmonology

Key words: COPD, Fut8, Core-fucosylation, SPARC, Matricellular protein, Collagen

Organism: Human

Tissue: Lung

Pathological State: Chronic obstructive pulmonary disease

561
Diffusion tensor imaging reveals brain structure changes in dogs after spinal cord injury

CB Liu, DG Yang, J Li, C Qin, X Zhang, J Liu, DP Li, JJ Li

Neural Regeneration Research (Publishing House of Neural Regeneration Research) China, 06 June 2022

Neuroscience

Key words: spinal cord injury, diffusion tensor imaging, canines, pathophysiology, cerebrospinal structures, corticospinal tract, magnetic resonance imaging, anisotropic fraction, apparent dispersion coefficient

Organism: Dog

Tissue: Brain

Pathological State: Spinal cord injury

562
Fecal Microbiota Transfer Attenuates Gut Dysbiosis and Functional Deficits After Traumatic Brain Injury

BT Davis, Z Chen, MBAR Islam, ME Timken, D Procissi, SJ Schwulst

Shock (Wolters Kluwer) USA, 06 June 2022

Neuroscience, Gastroenterology

Key words: Traumatic brain injury, fecal microbiome transplantation, microbiome, dysbiosis, trauma, controlled cortical impact, behavior, anxiety

Organism: Mouse

Tissue: Brain

Pathological State: Traumatic Brain Injury

563
FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1

Q Yang, F Wu, Y Zhang, R Wang

Journal of Cellular and Molecular Medicine (Wiley) China, 03 June 2022

Oncology

Key words: FOXM1, glycolysis, nasopharyngeal carcinoma, PDK1, proliferation

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

564
A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer

JN Zhou, B Zhang, HY Wang, DX Wang, MM Zhang, M Zhang, XK Wang, SY Fan, YC Xu, Q Zeng, YL Jia, JF Xi, X Nan, LJ He, XB Zhou, S Li, W Zhong, W Yue, XT Pei

Advanced Biology (Wiley) China, 02 June 2022

Oncology

Organism: Human

Cell Line: HCC cells

565
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma

X Huang, Y Huang, Z Lv, T Wang, H Feng, H Wang, S Du, S Wu, D Shen, C Wang, H Li, B Wang, X Ma, X Zhang

International Journal of Oncology (Spandidos Publications) China, 31 May 2022

Oncology

Organism: Human

Tissue: Kidney

Pathological State: Cancer

566
Ultra-Fine Polyethylene Hernia Meshes Improve Biocompatibility and Reduce Intraperitoneal Adhesions in IPOM Position in Animal Models

MJ Helmedag, D Heise, RM Eickhoff, SM Schmitz, M Mechelinck, C Emonts, T Bolle, T Gries, UP Neumann, CD Klink, A Lambertz

Biomedicines (MDPI) Germany, 31 May 2022

Tissue Engineering

Key words: polyethylene mesh, biocompatibility, IPOM, ultrafine diameter filaments, adhesion formation, animal trials

Tissue: Surgical mesh

567
Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice

C Liu, S Zhang, H Shi, H Zhou, J Zhuang, Y Cao, N Ward, J Wang

Brain Sciences (MDPI) China, USA, 30 May 2022

Neuroscience, Gastroenterology

Key words: microbiota-gut-brain axis, brain aging, gut microbiota, Atp11b, aging pathology

Organism: Mouse

Tissue: Brain

568
Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

R Liu, J Li, Y Xu, Z Chen, H Ye, J Tang, L Wei, L Liang

Investigative Ophthalmology & Visual Science (ARVO Journals) China, 26 May 2022

Ophthalmology

Organism: Human

Tissue: Meibomian Gland

569
Catalpol Attenuates Pulmonary Fibrosis by Inhibiting Ang II/AT1 and TGF-β/Smad-Mediated Epithelial Mesenchymal Transition

Q Yu, D Zhu, Y Zou, K Wang, P Rao, Y Shen

Frontiers in Medicine (Frontiers Media S.A.) China, 24 May 2022

Pulmonology

Key words: idiopathic pulmonary fibrosis, Ang II, TGF-β/Smad signaling pathway, EMT, catalpol

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

570
Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

R Ghiarasim, CE Tiron, A Tiron, MG Dimofte, M Pinteala, A Rotaru

Nanomaterials (MDPI) Romania, 24 May 2022

Nanomedicine

Key words: polyhistidine copolymers, micelles, doxorubicin, tumor cells, release studies

Cell Line: Micelles

571
Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma

P Chuntova, A Yamamichi, T Chen, R Narayanaswamy, S Ronseaux, C Hudson, AE Tron, ML Hyer, M Montoya, AL Mende, T Nejo, KM Downey, D Diebold, M Lu, B Nicolay, H Okada

Journal for ImmunoTherapy of Cancer (BMJ Journals) USA, 23 May 2022

Oncology, Immunology

Key words: Brain Neoplasms, Central Nervous System Neoplasms, Drug Evaluation, Preclinical, Programmed Cell Death 1 Receptor, Vaccination

Organism: Human

Cell Line: DTG-IDH1 cells

572
Tumor acidity-responsive polymeric nanoparticles to promote intracellular delivery of zoledronic acid by PEG detachment and positive charge exposure for enhanced antitumor potency

YH Chou, YL Liu, TC Hsu, JL Yow, BS Tzang, WH Chiang

Journal of Materials Chemistry B (Royal Society of Chemistry) Taiwan, 23 May 2022

Nanomedicine

Key words: Endocrinology

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

573
Adverse Effects of Single Neutrophil Extracellular Trap-Derived Components on Bovine Sperm Function

C Moya, R Rivera-Concha, F Pezo, P Uribe, M Schulz, R Sánchez, C Hermosilla, A Taubert, U Gärtner, F Zambrano

Animals (MDPI) Chile, Germany, 20 May 2022

Reproductive Medicine, Zoology

Key words: bovine, spermatozoon, bull, neutrophil extracellular traps, membrane integrity

Organism: Cattle

Cell Line: polymorphonuclear neutrophils, Spermatozoa

574
Topography-Mediated Enhancement of Nonviral Gene Delivery in Stem Cells

L Ge, L Yang, R Bron, P van Rijn

Pharmaceutics (MDPI) China, The Netherlands, 20 May 2022

Pharmacology

Key words: topography, proliferation, gene delivery, endocytosis, transfection

Organism: Human

Cell Line: hBM-MSCs

575
Di-(2-ethylhexyl) Phthalate Promotes Allergic Lung Inflammation by Modulating CD8α+ Dendritic Cell Differentiation via Metabolite MEHP-PPARγ Axis

HH Tseng, CY Li, ST Wu, HH Su, TH Wong, HE Wu, YW Chang, SK Huang, EM Tsai, JL Suen

Frontiers in Immunology (Frontiers Media S.A.) Taiwan, USA, 19 May 2022

Immunology

Key words: allergic lung inflammation, dendritic cell, PPAR γ, low-dose exposure, di-(2-ethylhexyl) phthalate, mono-(2-ethylhexyl) phthalate (MEHP)

Organism: Mouse

Tissue: Lung

Pathological State: Allergic Lung Inflammation

576
Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts

X Li, T Yong, Z Wei, N Bie, X Zhang, G Zhan, J Li, J Qin, J Yu, B Zhang, L Gfan, X Yang

Nature Communications (Nature) China, 19 May 2022

Oncology

Key words: Cancer immunotherapy, Cancer therapeutic resistance, Drug delivery

Organism: Mouse

Tissue: Liver

Pathological State: Cancer

577
Concurrent Germline and Somatic Mutations in FLCN and Preliminary Exploration of Its Function: A Case Report

T Wang, Y Yang, H Feng, B Cui, Z Lv, W Zhao, X Zhang, X Ma

Frontiers in Oncology (Frontiers Media S.A.) China, 19 May 2022

Oncology

Key words: Birt-Hogg-Dube (BHD) syndrome, folliculin (FLCN), mutation, renal cancer, TFEB/TFE3

Organism: Human

Tissue: Kidney

Pathological State: Cancer

578
Combination neoantigen-based dendritic cell vaccination and adoptive T-cell transfer induces antitumor responses against recurrence of hepatocellular carcinoma

S Peng, S Chen, W Hu, J Mei, X Zeng, T Su, W Wang, Z Chen, H Xiao, Q Zhou, B Li, Y Xie, H Hu, M He, Y Han, L Tang, Y Ma, X Li, X Zhou, Z Dai, Z Liu, J Tan, L Xu, S Li, S Shen, D Li, J Lai, B Peng, Z Peng, M Kuang

Cancer Immunology Research (AACR Publications) China, 18 May 2022

Oncology, Immunology

Organism: Human

Tissue: Liver

Pathological State: Cancer

579
Adenosine ameliorated Aβ25− 35-induced brain injury through the inhibition of apoptosis and oxidative stress via an ERα pathway

M Zeng, A Feng, C Zhao, B Zhang, P Guo, M Liu, Q Zhang, Y Zhang, R Fan, J Lyu, X Zheng

Brain Research (Elsevier) China, 18 May 2022

Neuroscience

Key words: Adenosine, Brain injury, ERα, Apoptosis, Oxidative stress

Organism: Mouse

Tissue: Brain

Pathological State: Brain injury

580
Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

M Schepelmann, M Ranieri, I Lopez-Fernandez, TS Webberley, SC Brennan, PL Yarova, J Graca, UK Hanif, C Müller, T Manhardt, M Salzmann, H Quasnichka, SA Price, DT Ward, T Gilbert, VV Matchkov, RA Fenton, A Herberger, J Hwong, C Santa Maria, CL Tu, E Kallay, G Valenti, W Chang, D Riccardi

Journal of The American Society of Nephrology (ASN) UK, Austria, Italy, Australia, USA, France, Denmark, 17 May 2022

Endocrinology

Key words: calcium-sensing receptor, mineral metabolism, vascular calcification, hypercalcemia, transgenic mouse, vascular smooth muscle

Organism: Mouse

Tissue: Kidney

581
Downregulated ADAMTS1 Incorporating A2M Contributes to Tumorigenesis and Alters Tumor Immune Microenvironment in Lung Adenocarcinoma

HC Lee, CY Chang, YC Huang, KL Wu, HH Chiang, YY Chang, LX Liu, JY Hung, YL Hsu, YY Wu, YM Tsai

Biology (MDPI) Taiwan, 16 May 2022

Oncology

Key words: A2M, ADAMTS1, EMT, immunity, LUAD, metastasis

Organism: Mouse

Tissue: Lung

Pathological State: Cancer

582
Organ‐specific immune response in lethal SARS‐CoV‐2 infection by deep spatial phenotyping

A Balachander, B Lee, SK Biswas, DC Lye, RTP Lin, YS Leo, P Chui, LFP Ng, L Renia

Clinical & Translational Immunology (Wiley) Singapore, 15 May 2022

SARS-CoV-2, Immunology

Key words: COVID-19, immunopathology, in situ spatial multiplexing, SARS-CoV-2 infection

Organism: Human

Tissue: Lung, Small Intestine, Heart

Pathological State: COVID-19

583
Translocon-associated protein subunit SSR3 determines and predicts susceptibility to paclitaxel in breast cancer and glioblastoma

C Dmello, A Sonabend, VA Arrieta, DY Zhang, D Kanojia, L Chen, A Gould, J Zhang, SJ Kang, J Winter, C Horbinski, C Amidel, B Győrffy, A Cordero, C Lee-Chang, B Castro, P Hsu, AU Ahmend, MS Lesniak, R Stupp, AM Sonabend

Clinical Cancer Research (AACR Publications) USA, Germany, Hungary, 12 May 2022

Oncology

Key words: Paclitaxel, biomarker, glioblastoma, breast cancer, SSR3

Organism: Mouse

Tissue: Breast

Pathological State: Cancer

584
Novel Elastic Threads for Intestinal Anastomoses: Feasibility and Mechanical Evaluation in a Porcine and Rabbit Model

SM Schmitz, MJ Helmedag, KM Kossel, RM Eickhoff, D Heise, A Kroh, M Mechelinck, T Gries, S Jockenhoevel, UP Neumann, A Lambertz

International Journal of Molecular Sciences (MDPI) Germany, The Netherlands, 11 May 2022

Tissue Engineering

Key words: biomaterial, TPU, surgical thread, suture material, elastic suture, gastrointestinal anastomosis

585
Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG4-related disease and Kimura disease

R Munemura, T Maehara, Y Murakami, R Koga, R Aoyagi, N Kaneko, A Doi, CA Perugino, E Della-Torre, T Saeki, Y Sato, H Yamamoto, T Kiyoshima, JH Stone, S Pillai, S Nakamura

Journal of Allergy and Clinical Immunology (Elsevier) Japan, USA, Italy, 11 May 2022

Immunology

Key words: Single-cell RNA sequencing, IgG4-related disease, IgG4-RD, IgG4, IgE, Tfh cell, B cell, interleukin-10, class switch, fibrosis

Organism: Human

Tissue: Salivary Gland

Pathological State: IgG4-related disease, Kimura disease

586
In vitro testicular toxicity of environmentally relevant endocrine-disrupting chemicals: 2D vs. 3D models of prepubertal Leydig TM3 cells

E Sychrová, A Yawer, P Labohá, A Basu, A Dydowiczová, I Virmani, P Babica, I Sovadinová

Environmental Toxicology and Pharmacology (Elsevier) Czech Republic, 10 May 2022

Reproductive Medicine, Toxicology

Key words: 3D in vitro models, Endocrine-disrupting chemicals, Leydig cells, Lipotoxicity, Reproductive toxicity, Spheroids

Tissue: Spheroid

Cell Line: Leydig TM3 cells

587
AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice—A Pilot Study

M Schepelmann, N Kupper, V Gushchina, I Mesteri, T Manhardt, S Moritsch, S Müller, K Piatek, M Salzman, A Vlasaty, R Eferl, E Kallay

International Journal of Molecular Sciences (MDPI) Austria, Germany, 09 May 2022

Oncology, Gastroenterology

Key words: aged mice, colitis associated colorectal cancer, AOM, DSS, mouse strain differences, pilot study

Organism: Mouse

Tissue: Colon

Pathological State: Cancer

588
Hybrid PEGylated chitosan/PLGA nanoparticles designed as pH-responsive vehicles to promote intracellular drug delivery and cancer chemotherapy

SJ Huang, TH Wang, YH Chou, HMD Wang, TC Hsu, JL Yow, BS Tzang, WH Chiang

International Journal of Biological Macromolecules (Elsevier) Taiwan, 05 May 2022

Nanomedicine, Oncology

Key words: Acidity-responsive nanovehicles, PEGylated chitosan, cancer chemotherapy

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

589
Multinucleated Retinal Pigment Epithelial Cells Adapt to Vision and Exhibit Increased DNA Damage Response

Q Ke, L Gong, X Zhu, R Qi, M Zou, B Chen, W Liu, S Huang, Y Liu, DWC Li

Cells (MDPI) China, 05 May 2022

Key words: multinucleation, retinal pigment epithelium, reactive oxygen species, photoreceptor, DNA damage, p53

Organism: Mouse

Tissue: Eye

590
Macrophage-associated immune checkpoint CD47 blocking ameliorates endometriosis

J Li, S Yan, Q Li, Y Huang, M Ji, X Jiao, M Yuan, G Wang

Molecular Human Reproduction (Oxford Academic) China, 05 May 2022

Reproductive Medicine

Key words: apoptosis, endometriosis, immune checkpoint, immunotherapy, macrophage, phagocytosis

Organism: Human

Tissue: Endometrium

Pathological State: Endometriosis

591
DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide

MT Latancia, NC Moreno, GS Leandro, V Chaves Ribeiro, I de Souza, W Kleber Martins Vieira, A Uchimura Bastos, NC Hoch CRR Rocha, CFM Menck

Mutation Research/Genetic Toxicology and Environmental Mutagenesis (Elsevier) Brazil, 05 May 2022

Toxicology

Key words: XP-V, Temozolomide, Polymerase eta, DNA damage, Translesion synthesis, Cisplatin

Organism: Human

Cell Line: TLS-deficient cell line XP30RO

592
miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization

N Li, X Wang, J Sun, Y Liu, A Han, Z Lin, Y Yang

Carcinogenesis (Oxford Academic) China, 02 May 2022

Oncology

Key words: Tiam1, breast cancer, metastasis, glucose metabolism reprogramming, miR-21-5p

Organism: Human

Cell Line: BC cell lines

593
SAM and folic acid prevent arsenic-induced oxidative and nitrative DNA damage in human lymphoblast cells by modulating expression of inflammatory and DNA repair genes

T Boonma, P Navasumrit, V Parnlob, S Waraprasita, M Ruchirawatac

Chemico-Biological Interactions (Elsevier) Thailand, 02 May 2022

Toxicology

Key words: Arsenic, S-adenosyl methionine (SAM), Folic acid, DNA methylation, 8-hydroxydeoxyguanosine (8-OHdG), 8-nitroguanine

Organism: Human

Cell Line: Lymphoblast cells (RPMI 1788)

594
Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse

W Huang, Q Xu, F Liu, J Su, D Xiao, L Tang, ZZ Hao, R Liu, K Xiang, Y Bi, Z Miao, X Liu, Y Liu, S Liu

Investigative Ophthalmology & Visual Science (ARVO Journals) China, UK, 02 May 2022

Ophthalmology, Neuroscience

Organism: Mouse

Tissue: Eye

595
ITGB1 Suppresses Autophagy Through Inhibiting The mTORC2/AKT Signaling Pathway In H9C2 Cells

W Zhou, W Liu, D Zhou, A Li

Die Pharmazie-An International Journal of Pharmaceutical Sciences (Avoxa - Mediengruppe Deutscher Apotheker GmbH) China, 01 May 2022

Pharmacology

Organism: Rat

Tissue: Heart

596
Prognostic Value of Characterizing Myocardial Tissue by Cardiac MRI with T1 Mapping in HFpEF Patients: A Systematic Review and Meta-Analysis

E Golukhova, N Bulaeva, S Alexandrova, O Gromova, B Berdibekov

Journal of Clinical Medicine (MDPI) Russia, 30 April 2022

Cardiology

Key words: cardiac MRI, HFpEF, T1 mapping, extracellular volume, native T1, postcontrast T1, prognosis

597
The Overexpression of Insulin-Like Growth Factor-1 and Neurotrophin-3 Promote Functional Recovery and Alleviate Spasticity After Spinal Cord Injury

Z Talifu, C Qin, Z Xin, Y Chen, J Liu, S Dangol, X Ma, H Gong, Z Pei, Y Yu, J Li, L Du

Frontiers in Neuroscience (Frontiers Media S.A.) China, 29 April 2022

Neuroscience

Key words: spinal cord injury, nerve repair, nerve growth factor, NT-3, IGF-1, motor function recovery, spasticity, mechanical pain

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

598
Epidermotropism of inflammatory cells differentiates pyoderma gangrenosum from venous leg ulcers

M Ronicke, A Baur, M Kirr, M Erdmann, C Erfurt-Berge, C Ostalecki

Journal of the German Society of Dermatology (Wiley) Germany, 29 April 2022

Dermatology

Organism: Human

Tissue: Skin

Pathological State: Ulcer

599
Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in a mouse transplantation model

JF Fu, CJ Wen, TH Yen, LY Shih

Neoplasia (Elsevier) Taiwan, 29 April 2022

Oncology

Key words: MLL translocation, KRAS mutation, Hoxa11, Hoxa10, Myeloid sarcoma, Migration

Organism: Mouse

Cell Line: Mouse MLL/AF10 leukemia cell lines

600
Prognostic values of B7-H3, B7-H4, and HHLA2 expression in human pancreatic cancer tissues based on mIHC and spatial distribution analysis

Y Zhu, J Chen, Y Liu, X Zheng, J Feng, X Chen, T Jiang, Y Li, L Chen

Pathology-Research and Practice (Elsevier) China, 29 April 2022

Oncology

Key words: B7-H3, B7-H4, HHLA2, Multi-color immunohistochemistry, Prognosis, Pancreatic cancer

Organism: Human

Tissue: Pancreas

Pathological State: Cancer

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