Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2101 - 2110 of 3451
2101
Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation

A Quarta, D Le Blon, T D'aes, Z Pieters, SH Taj, F Miro-Mur, E Luyckx, E Van Breedam, J Daans, H Goossens, S Dewilde, N Hens, V Pasque, AM Planas, M Hoehn, Z Berneman, P Ponsaerts

Brain, Behavior, and Immunity (Elsevier) Belgium, Germany, Spain, The Netherlands , 13 September 2019

Immunology, Neuroscience

Key words: iPSC, Microglia, Macrophages, Stroke, Neuroinflammation, Interleukin (IL) 13, Polarisation, Classical activation, Alternative activation

Organism: Mouse

Tissue: Brain

2102
The Effect of Wharton Jelly-Derived Mesenchymal Stromal Cells and Their Conditioned Media in the Treatment of a Rat Spinal Cord Injury

M Chudickova, I Vackova, L Machova Urdzikova, P Jancova, K Kekulova, M Rehorova, K Turnovcova, P Jendelova, S Kubinova

International Journal of Molecular Sciences (MDPI) Czech Republic , 12 September 2019

Neuroscience

Key words: spinal cord injury, mesenchymal stem cells, Wharton's jelly, conditioned medium, cell secretome, cell therapy

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

2103
Next-generation computational tools for interrogating cancer immunity

F Finotello, D Rieder, H Hackl, Z Trajanoski

Nature Reviews Genetics (Nature) Austria , 12 September 2019

Oncology

Key words: Antigen presentation, Cancer genetics, Cancer genomics, Cancer immunotherapy, Computational biology and bioinformatics, Tumor immunology

2104
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

X Wu, C Lei, T Xia, X Zhong, Q Yang, HB Shu

Nature Communications (Nature) China , 11 September 2019

Immunology

Key words: Bacterial Infection, Innate immune cells, Pattern recognition receptors, Ubiquitylation

Organism: Mouse

Tissue: Lung

2105
Region-specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation

G Gussak, A Pfenniger, L Wren, M Gilani, W Zhang, S Yoo, DA Johnson, A Burrell, B Benefield, G Knight, BP Knight, R Passman, JJ Goldberger, G Aistrup, JA Wasserstrom, Y Shiferaw, R Arora

JCI Insight (American Society of Clinical Investigation) USA , 10 September 2019

Neuroscience

Organism: Dog

Tissue: Heart

2106
Calcium‐sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice

Z Cheng, A Li, CL Tu, C Santa Maria, N Szeto, A Herberger, TH Chen, F Song, J Wang, X Liu, DM Shoback, W Chang

Journal of Bone and Mineral Research (Wiley) USA , 09 September 2019

Osteology

Key words: chondrogenesis, osteogenesis, endochondral bone formation, cartilage, chondrocyte, osteoblast, CaSR knockout, unfixed fracture, fracture healing

2107
Worm-Based Alternate Assessment of Probiotic Intervention against Gut Barrier Infection

J Kim, Y Moon

Nutrients (MDPI) South Korea , 08 September 2019

Immunology

Key words: Gut health, Probiotics, Caenorhabditis elegans, Epithelial barrier infection

Organism: Mouse

Tissue: Colon

Pathological State: Worm Infestation

2108
Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation

BG Durgin, SA Hahn, HM Schmidt, MP Miller, N Hafeez, I Mathar, D Freitag, P Sandner, AC Straub

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, Germany , 05 September 2019

Cardiology

Organism: Mouse

Tissue: Heart

2109
ATMIN is a tumor suppressor gene in lung adenocarcinoma

H Foster, E Josue Ruiz, C Moore, GWH Stamp, EL Nye, N Li, Y Pan, Y He, J Downward, A Behrens

Cancer Research (AACR Publications) UK , 03 September 2019

Oncology

2110
Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer

TT Wei, YT Lin, SP Tang, CK Luo, CT Tsai, CT Shun, CC Chen

Oncogene (Nature) Taiwan , 02 September 2019

Oncology

Key words: Cancer therapeutic resistance, Tumor angiogenesis

Organism: Mouse

Tissue: Blood Vessels

Pathological State: Cancer

Results 2101 - 2110 of 3451

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