Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 1821 - 1830 of 3451
1821
Bioinstructive Micro-Nanotextured Zirconia Ceramic Interfaces for Guiding and Stimulating an Osteogenic Response In Vitro

L Elena Sima, A Bonciu, M Baciu, I Anghel, LN Dumitrescu, L Rusen, V Dinca

Nanomaterials (MDPI) Romania , 09 December 2020

Nanomedicine

Key words: Zirconia, Mesenchymal Stem Cells, Micro-Nano Topography, Osteogenic Differentiation, Bone-Anchored Hearing Aid (BAHA)

Organism: Human

Cell Line: hMSCs

1822
The effect of dietary supplementation with high-or low-dose omega-3 fatty acid on inflammatory pathology after traumatic brain injury in rats

EK Black, JK Phillips, J Seminetta, J Bailes, JM Lee, JD Finan

Translational Neuroscience (degruyter) USA , 09 December 2020

Neuroscience

Key words: Dietary Supplementation, Docosahexanoic Acid, Eicosapentaenoic Acid, Neuroinflammation, Neuroprotection, Omega-3 Fatty Acid, Traumatic Brain Injury

Organism: Rat

Tissue: Brain

Pathological State: Traumatic Brain Injury

1823
Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis

W Kang, Q Wang, Y Dai, H Wang, M Wang, J Wang, D Zhang, P Sun, T Qi, X Jin, Z Cui

Cell Death & Disease (Nature) China , 07 December 2020

Oncology

Key words: Bladder Cancer, Long Non-Coding RNAs, Oncogenesis

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

1824
Integrative single-cell transcriptome analysis reveals a subpopulation of fibroblasts associated with favorable prognosis of liver cancer patients

H Wang, C Feng, M Lu, B Zhang, Y Xu, Q Zeng, J Xi, J Zhou, X Ying, J Zhang, W Yue, X Pei

Translational Oncology (Elsevier) China , 06 December 2020

Oncology

Key words: Liver Cancer, Single-Cell Transcriptome, Cancer-Distinct Fibroblast, SPARCL1

Organism: Human

Tissue: Liver

Pathological State: Cancer

1825
Lactic acidosis interferes with toxicity of perifosine to colorectal cancer spheroids: multimodal imaging analysis

B Pavlatovská, M Machálková, P Brisudová, A Pruška, K Štěpka, J Michálek, T Nečasová, P Beneš, J Šmarda, J Preisler, M Kozubek, J Navrátilová

Frontiers in Oncology (Frontiers Media S.A.) Czech Republic, Switzerland, China , 04 December 2020

Oncology

Key words: Perifosine, Akt Kinase, Tumor Environment, Lactic Acidosis, Alkalization, Signal Co-Registration, Mass Spectrometry Imaging, Colorectal Cancer

Organism: Human

Cell Line: HT-29 and HCT-116 cells

1826
AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

G Caluori, E Odehnalova, T Jadczyk, M Pesl, I Pavlova, L Valikova, S Holzinger, V Novotna, V Rotrekl, A Hampl, M Crha, D Cervinka, Z Starek

Frontiers in Bioengineering and Biotechnology (Frontiers Media S.A.) Czech Republic, France, Poland, Germany , 03 December 2020

Cardiology

Key words: Pulsed Field Ablation, Irreversible Electroporation (IRE), Radiofrequency Ablation, Atrial Fibrillation, Ventricular Arrhythmia (VA), Preclinical Cardiology

Organism: Pig

Tissue: Heart

1827
Shear stress-exposed pulmonary artery endothelial cells fail to upregulate HSP70 in chronic thromboembolic pulmonary hypertension

W Salibe-Filho, TLS Araujo, EG Melo, LBCT Coimbra, MS Lapa, MMP Acencio, O Freitas-Filho, VL Capelozzi, LR Teixeira, CJCS Fernandes, F Biscegli Jatene, FRM Laurindo, M Terra-Filho

PLoS One (PLOS) Brazil , 03 December 2020

Cardiology

Key words: Shear Stresses, Endothelial Cells, Heat Shock Response, Pulmonary Arteries, Peas, Flow Cytometry, Nitric Oxide, Pulmonary Hypertension

Organism: Human

Pathological State: Pulmonary hypertension

Cell Line: HPAECs

1828
Infiltration of metastatic lymph nodes with PD-1+ T cells is associated with improved disease-free and overall survival in resected N+ NSCLC

S Wang, Y Song, MA Morse, P Sun, G Qiao, X Wang, X Zhou, A Hobeika, J Ren, HK Lyerly

American Journal of Cancer Research (e-Century Publishing Corporation) China, USA , 01 December 2020

Oncology

Key words: NSCLC, Metastatic Lymph Node, T Cell Subsets, PD-1, TIM-3

Organism: Human

Tissue: Lung

Pathological State: Cancer

1829
The predictive power of CD3+ T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients

G Spanier, I Ugele, F Nieberle, L Symeou, S Schmidhofer, A Brand, J Meier, S Spoerl, R Krupar, P Rümmele, P Siska, K Renner, K Peter, M Gerken, P Beckhove, TE Reichert, M Kreutz, K Singer

Cancer Letters (Elsevier) Germany , 01 December 2020

Oncology

Key words: OSCC, Diabetes Mellitus, TIL, Metabolism, Prognosis

Organism: Human

Pathological State: Cancer

1830
p21‐activated kinase 4 promotes the progression of esophageal squamous cell carcinoma by targeting LASP1

H Huang, Q Xue, X Du, J Cui, J Wang, D Cheng, J Li, Y Zheng, G Huang, K Zhang, K Liu, J Lu, J Zhao, X Chen, Z Dong, X Li

Molecular Carcinogenesis (Wiley) China , 01 December 2020

Oncology

Key words: Cell Proliferation, Esophageal Squamous Cell Carcinoma, LASP1, Metastasis, PAK4

Organism: Human

Tissue: Esophagus

Pathological State: Cancer

Results 1821 - 1830 of 3451

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TissueGnostics provides advanced solutions for whole-slide imaging and image analysis in biological and clinical research. Our products help researchers to scan and analyze complex tissue samples, enabling more detailed insights into tissue structure, cellular interactions, and spatial cell landscape.

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