Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

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Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 2241 - 2250 of 3451
2241
Histo-genomics: digital pathology at the forefront of precision medicine

Mark L Graber, Mario Plebani

Diagnosis (De Gruyter) Canada , 20 December 2018

Pathology

2242
Spatial mapping of myeloid cells and macrophages by multiplexed tissue staining

Joshua Saylor, Zhaoxuan Ma, Helen S Goodridge, Fangjin Huang, Anne E Cress, Stephen J Pandol, Stephen L Shiao, Adriana C Vidal, Lily Wu, Nicholas G Nickols, Arkadiusz Gertych and Beatrice S Knudsen

Frontiers in Immunology (Frontiers Media S.A.) USA , 14 December 2018

Immunology

Key words: FFPE, immunofluorescence, immunohistochemistry, macrophage, multiplex, myeloid, spatial profiling

Organism: Human

Tissue: Colon, Lymphoid Tissue

Pathological State: Cancer

2243
Predominant Striatal Input to the Lateral Habenula in Macaques Comes from Striosomes

Simon Hong, Satoko Amemori, Emily Chung, Daniel J Gibson, Ken-ich iAmemori, Ann MGraybiel

Current Biology (Cell Press) USA, Japan , 13 December 2018

Neuroscience

Key words: basal ganglia, dopamine, motivation, non-human primate, mood, learning, microstimulation

Organism: Monkey

Tissue: Brain

2244
Melanocyte-specific gene 1 promotes melanoma progression by enhancing the expression of Bcl-2

Hui Zhao, Guosheng Wu, Ji Zhu, Mengyan Sun, Yuchong Wang, Yongjie Fan, Kai Wu, Hongda Bi, Haiying Dai, Chuan Lv, Chunyu Xue

Oncology Letters (Spandidos Publications) China , 12 December 2018

Oncology

Key words: melanocyte-specific gene 1, melanoma, cell viability, apoptosis, Bcl-2

Organism: Human

Tissue: Skin

Pathological State: Cancer

2245
The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma

Viktoria Laszlo, Zsuzsanna Valko, Judit Ozsvar, Ildiko Kovacs, Tamas Garay, Mir Alireza Hoda, Thomas Klikovits, Paul Stockhammer, Clemens Aigner, Marion Gröger, Walter Klepetko, Walter Berger, Michael Grusch, Jozsef Tovari, Irene C Waizenegger, Balazs Dome, Balazs Hegedus

Journal of Molecular Medicine (Springer) Austria, Germany, Hungary , 11 December 2018

Oncology

Key words: Mesothelioma, Focal adhesion kinase, Tyrosine kinase inhibitor, Angiogenesis, Spheroid formation, Orthotopic xenograft

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2246
Anti-inflammatory compound curcumin and mesenchymal stem cells in the treatment of spinal cord injury in rats.

Jiri Ruzicka, Lucia Machova Urdzikova, Anna Kloudova, Anubhav G Amin, Jana Vallova, Sarka Kubinova, Meic H Schmidt, Meena Jhanwar‑Uniyal and Pavla Jendelova

Acta Neurobiologiae Experimentalis (Nencki Institute of Experimental Biology) Czech Republic, USA , 05 December 2018

Regenerative Medicine

Key words: Spinal cord injury, human mesenchymal stem cells, curcumin, combined therapy, inflammatory response

Organism: Rat

Tissue: Spinal Cord

Pathological State: Spinal Cord Injury

Cell Line: Human mesenchymal stem cells (hMSCs)

2247
The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma

Ying Liu, Xinhua Wang, Shuang Zeng, Xiane Zhang, Jimin Zhao, Xiaoyan Zhang, Xinhuan Chen, Wanjing Yang, Yili Yang, Ziming Dong, Jingyu Zhu Xin Xu, Fang Tian

Journal of Experimental & Clinical Cancer Research (Springer) China , 05 December 2018

Oncology

Key words: Curcumin, STAT3, Esophageal squamous cell carcinoma, Apoptosis, PDX model

Organism: Mouse

Tissue: Xenograft Tumor

Pathological State: Cancer

2248
CXCL5 as regulator of neutrophil function in cutaneous melanoma

A Forsthuber, K Lipp, L Andersen, S Ebersberger, O Grana-Castro, W Ellmeier, P Petzelbauer, BM Lichtenberger, R Loewe

Journal of Investigative Dermatology (Elsevier) Austria, Germany, Spain , 04 December 2018

Oncology, Dermatology

Organism: Mouse

Tissue: Lung, Xenograft Tumor

Pathological State: Cancer

2249
Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression

Bing Song, Su-Hong Park, Jonathan C Zhao, Ka-wing Fong, Shangze Li, Yongik Lee, Yeqing A Yang, Subhasree Sridhar, Xiaodong Lu, Sarki A Abdulkadir, Robert L Vessella, Colm Morrissey, Timothy M Kuzel, William J Catalona, Ximing J Yang, and Jindan Yu

The Journal of Clinical Investigation (American Society for Clinical Investigation) USA, China , 04 December 2018

Oncology

Key words: Genetics, Oncology, Prostate cancer

Organism: Human

Tissue: Prostate

Pathological State: Cancer

2250
Extracellular vesicles from mature dendritic cells (DC) differentiate monocytes into immature DC

Stefan Schierer, Christian Ostalecki, Elisabeth Zinser, Ricarda Lamprecht, Bianca Plosnita, Lena Stich, Jan Dörrie, ProfileManfred B Lutz, ProfileGerold Schuler, ProfileAndreas S Baur

Life Science () Germany, Austria , 03 December 2018

Immunology

Key words: Medical Research, Immunology

Organism: Human, Mouse

Cell Line: Monocyte-derived dentritic cells

Results 2241 - 2250 of 3451

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