Checkpoint Molecules Predict Response to Immunotherapy in Cancer

FEATURED PUBLICATION

Checkpoint Molecules Predict Response to Immunotherapy in Cancer
cells

Heij et al. investigated the expression of checkpoint molecules in the tumor microenvironment of intrahepatic cholangio-carcinoma. They found that co-expression patterns of checkpoint molecules such as PD-L1 and TIGIT correlate with metastases and poor prognosis. TissueFAXS and StrataQuest were used to image the mIF-stained samples and assess protein expression.

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Community-developed Checklists Enhance Reproducibility of Microscopy Images

FEATURED PUBLICATION

Community-developed checklists for publishing images and image analyses
Nature Methods

QUAREP-LiMi is an initiative focused on promoting quality assessment and reproducibility for instruments and images in light microscopy. Dr. Rupert Ecker, CEO of TissueGnostics, participated in developing standardized guidelines for best practices in image communication. These checklists offer key recommendations on image formatting and annotation among others.

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AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma

FEATURED PUBLICATION

AI-Assisted Analysis of ‘Anti-/Pro-Tumor’ Profiles for Pancreatic Adenocarcinoma
Cancer Biology & Medicine

To predict survival of patients with pancreatic adenocarcinoma, Zhou et al. performed an AI-assisted comprehensive analysis of CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB). They used StrataQuest image analysis software to automatically detect and quantify tumor-infiltrating CD8+ T cells, CD133+ CSCs, and CK19+ TB.

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Characterization of the Spatial Immune Context of Lung Cancer

FEATURED PUBLICATION

Characterization of the Spatial Immune Context of Lung Cancer
International Journal of Molecular Sciences

In a recent study, Imamura et al. investigated the role of debrin-expressing tumor infiltration lymphocytes (TIL) in lung cancer. The high-end image analysis solution, StrataQuest, was used for the automatic tissue classification and localization of CD3+/debrin+ cellular phenotypes in the tumor cell nest, as well as in the stroma.

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COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma

FEATURED PUBLICATION

COL8A1 Promotes Tumor in Pancreatic Ductal Adenocarcinoma
Matrix Biology

Yan et al. investigated several collagen subtypes involved in pancreatic ductal adenocarcinoma desmoplasia. Based on this study, COL8A1 was suggested as a new marker for predicting poor chemotherapy responsiveness and survival. The TissueFAXS imaging platform and StrataQuest analysis solution were used to image and segment morphological structures.

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Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis

FEATURED PUBLICATION

Erk1/2-Dependent HNSCC Cell Susceptibility to Erastin-Induced Ferroptosis
cells

Savic et al. investigated the Erk 1/2 pathway role in ferroptosis induction by targeting xCT protein during the treatment of HNSCC. They found erastin to be a potent ferroptosis inducer which is strongly dependent on Erk 1/2 kinases. TissueFAXS and HistoQuest were used to image the IHC-stained samples and calculate the percentage of xCT-positive cells.

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Tumor Microenvironment Characterization of Rectal Cancer

FEATURED PUBLICATION

Case Report: Tumor Microenvironment Characterization of Rectal Cancer
Frontiers in Immunology

Song et al. published a case study investigating the genetics and tumor microenvironment of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis. TissueFAXS and StrataQuest were used to image stained tissue samples and to assess tumor infiltrating immune cells using, among others, CD4, CD8, CD163, PD1, and PD-L1 as markers.

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Adverse Effects of Single

FEATURED PUBLICATION

The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of TFRs within human lymph nodes
BMC Immunology

Mahlobo et al. published a study in BMC Immunology addressing the effect of HIV infections on frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) in human lymph nodes. TFRs within lymph node tissues were quantified using TissueFAXS i PLUS and TissueQuest.

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Temporal changes

FEATURED PUBLICATION

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19
Clinical Immunology

Kaneko et al. published a study in the Clinical Immunology journal focusing on the quantitative analysis of T-cell subset alterations in thoracic lymph nodes and lung samples of COVID-19 patients. With the help of TissueFAXS and StrataQuest, the authors were first to show the expansion of cytotoxic CD4+ T cells in the lungs of patients with severe COVID-19.

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Spatial Distribution

FEATURED PUBLICATION

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development
Molecular Therapy

In a recent publication in the journal Molecular Therapy, Wang et al (Cheeloo Medical College of Shandong University) combine multiplexing and TissueGnostics’ image cytometry solutions for the assessment of the expression level of Tim-3, a well-known immune checkpoint, in tumor infiltrating lymphocytes. This study nominates Tim-3 as a potential target for cancer immunotherapy.

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Multi-Antigen Imaging

FEATURED PUBLICATION

Multi-Antigen Imaging Reveals Inflammatory DC, ADAM17 and Neprilysin as Effectors in Keloid Formation
International Journal of Molecular Sciences

In a recent publication in the MDPI - International Journal of Molecular Sciences, Rath et al (University Hospital Heidelberg) combine multiplexing, TissueGnostics’ image cytometry and in-depth data mining to characterize the immune microenvironment including spatial relationships within keloid lesions. Using this approach, the authors were able to nominate potential therapeutic targets.

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SynNotch-CAR T

FEATURED PUBLICATION

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Science Translational Medicine

A recent publication from the group of Choe et al. (University of California, UCSF) published in Science Translational research is exploring the therapeutic effectiveness of SynNotch-CAR T cells in a PDX glioblastoma mouse model. T cells in-situ were imaged/assessed by TissueFAXS and quantified via StrataQuest.

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CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer

FEATURED PUBLICATION

CpG Methylation Influence on Protease Serine 3 Isoforms in Lung Cancer
Acta Pharmaceutica Sinica B

Lin et al. investigated the UHRF1/DNMT1–MZF1 axis in the context of CpG methylation of protease serine 3, a protein with several isoforms that show paradoxical effects. To differentiate the isoforms, the researchers employed 7-marker multiplex staining and performed a quantitative analysis using TissueFAXS SPECTRA and StrataQuest.

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Customer Publications (A total of 3451 papers published)

Results 1371 - 1380 of 3451
1371
Fecal Microbiota Transfer Attenuates Gut Dysbiosis and Functional Deficits After Traumatic Brain Injury

BT Davis, Z Chen, MBAR Islam, ME Timken, D Procissi, SJ Schwulst

Shock (Wolters Kluwer) USA , 06 June 2022

Neuroscience, Gastroenterology

Key words: Traumatic brain injury, fecal microbiome transplantation, microbiome, dysbiosis, trauma, controlled cortical impact, behavior, anxiety

Organism: Mouse

Tissue: Brain

Pathological State: Traumatic Brain Injury

1372
FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1

Q Yang, F Wu, Y Zhang, R Wang

Journal of Cellular and Molecular Medicine (Wiley) China , 03 June 2022

Oncology

Key words: FOXM1, glycolysis, nasopharyngeal carcinoma, PDK1, proliferation

Organism: Human

Tissue: Mucosa

Pathological State: Cancer

1373
A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer

JN Zhou, B Zhang, HY Wang, DX Wang, MM Zhang, M Zhang, XK Wang, SY Fan, YC Xu, Q Zeng, YL Jia, JF Xi, X Nan, LJ He, XB Zhou, S Li, W Zhong, W Yue, XT Pei

Advanced Biology (Wiley) China , 02 June 2022

Oncology

Organism: Human

Cell Line: HCC cells

1374
Ultra-Fine Polyethylene Hernia Meshes Improve Biocompatibility and Reduce Intraperitoneal Adhesions in IPOM Position in Animal Models

MJ Helmedag, D Heise, RM Eickhoff, SM Schmitz, M Mechelinck, C Emonts, T Bolle, T Gries, UP Neumann, CD Klink, A Lambertz

Biomedicines (MDPI) Germany , 31 May 2022

Tissue Engineering

Key words: polyethylene mesh, biocompatibility, IPOM, ultrafine diameter filaments, adhesion formation, animal trials

Tissue: Surgical mesh

1375
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma

X Huang, Y Huang, Z Lv, T Wang, H Feng, H Wang, S Du, S Wu, D Shen, C Wang, H Li, B Wang, X Ma, X Zhang

International Journal of Oncology (Spandidos Publications) China , 31 May 2022

Oncology

Organism: Human

Tissue: Kidney

Pathological State: Cancer

1376
Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice

C Liu, S Zhang, H Shi, H Zhou, J Zhuang, Y Cao, N Ward, J Wang

Brain Sciences (MDPI) China, USA , 30 May 2022

Neuroscience, Gastroenterology

Key words: microbiota-gut-brain axis, brain aging, gut microbiota, Atp11b, aging pathology

Organism: Mouse

Tissue: Brain

1377
Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway

R Liu, J Li, Y Xu, Z Chen, H Ye, J Tang, L Wei, L Liang

Investigative Ophthalmology & Visual Science (ARVO Journals) China , 26 May 2022

Ophthalmology

Organism: Human

Tissue: Eye

1378
Catalpol Attenuates Pulmonary Fibrosis by Inhibiting Ang II/AT1 and TGF-β/Smad-Mediated Epithelial Mesenchymal Transition

Q Yu, D Zhu, Y Zou, K Wang, P Rao, Y Shen

Frontiers in Medicine (Frontiers Media S.A.) China , 24 May 2022

Pulmonology

Key words: idiopathic pulmonary fibrosis, Ang II, TGF-β/Smad signaling pathway, EMT, catalpol

Organism: Mouse

Tissue: Lung

Pathological State: Pulmonary Fibrosis

1379
Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

R Ghiarasim, CE Tiron, A Tiron, MG Dimofte, M Pinteala, A Rotaru

Nanomaterials (MDPI) Romania , 24 May 2022

Nanomedicine

Key words: polyhistidine copolymers, micelles, doxorubicin, tumor cells, release studies

Cell Line: Micelles

1380
Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma

P Chuntova, A Yamamichi, T Chen, R Narayanaswamy, S Ronseaux, C Hudson, AE Tron, ML Hyer, M Montoya, AL Mende, T Nejo, KM Downey, D Diebold, M Lu, B Nicolay, H Okada

Journal for ImmunoTherapy of Cancer (BMJ Journals) USA , 23 May 2022

Oncology, Immunology

Key words: Brain Neoplasms, Central Nervous System Neoplasms, Drug Evaluation, Preclinical, Programmed Cell Death 1 Receptor, Vaccination

Organism: Human

Cell Line: DTG-IDH1 cells

Results 1371 - 1380 of 3451

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