Dr Suzanne Turner in the Department of Pathology is the coordinator of a successful bid for a €4 million European Union Marie Curie Innovative Training Network
The European Research Initiative for ALK-related malignancies (ERIA: www.erialcl.net) forms the core of a successful proposal for a European Training Network (ETN). Dr Suzanne Turner of the Department of Pathology, University of Cambridge is the coordinator of the network and together with Prof Lukas Kenner (Ludwig Boltzmann Institute for Cancer Research, Vienna) and Dr Olaf Merkel (Medical University Vienna) formed a consortium around some of the leading researchers focussing on malignancies driven by the oncogene Anaplastic Lymphoma Kinase (ALK) to facilitate the development of less-toxic and more efficacious therapies. The consortium of 14 research groups based in 7 European countries developed a competitive training programme for 15 PhD students, which is complemented by an array of companies and other research organisations.
With a score of 95.4 the ETN made it into the top 6.3 % out of more than 1,300 proposals to obtain an invitation for funding. This makes European Training Networks one of the most competitive funding opportunities available within HORIZON2020. “With ERIA we have based this proposal on an existing network of academic research collaboration, which will now be reinforced through the incorporation of several companies. I hope this will speed up the translation of our research into novel and improved therapies” said Dr Suzanne Turner. The core focus of the consortium which is called ALKATRAS: Break free from cancer, is to investigate mechanisms employed by the ALK oncogene to induce a variety of cancers including lymphoma, neuroblastoma and lung cancer. In doing so, it is hoped that novel therapeutic targets will be discovered and treatments for these developed together with the assistance of a number of companies based within Europe.http://www.erialcl.net/
STAT3 regulated ARF expression suppresses prostate cancer metastasis in Nature Communications
Interleukin 6 (IL-6) is an important cytokine that controls the cell survival and tumor growth. Hyperactive IL-6 may support cancer growth, particularly as it controls STAT3, which was shown to have an oncogenic role in most tumours. Many therapies are therefore designed to suppress IL-6 or STAT3. But the situation is different in prostate cancer. Lukas Kenner's research group has shown that, contrary to expectations; active STAT3 suppresses cell growth in prostate tumours. It activates the gene p14ARF, which blocks cell division and thus inhibits tumour growth. “Using knockout mice, which are preclinical model organisms, we can link IL-6/Stat3 signalling to ARF, an important gene for cell cycle control and decisions to grow or to arrest. These findings have consequences for prostate cancer metastasis,” explained Jan Pencik, who recently obtained his PhD at the Ludwig Boltzmann Institute for Cancer Research based on this research.
Beatrice Grabner presents STAT3 playing an important role in the defence against tumors in Nature Communications
Lung cancer is one of the most common tumor-related causes of death, because it is one of the most aggressive cancers. Since the treatment methods especially in cigarette smoke-induced lung cancer are extremely limited, there is an urgent medical need to establish new treatment options.
Insights into activated signaling pathways, which play an essential role in cigarette smoke-induced lung cancer can be a starting point for new targeted therapies and and can serve as potential therapeutic approaches.
The transcription factor STAT3 has a growth-promoting role in leukemia and colorectal cancer and various treatment approaches to block STAT3 are already in clinical development.
As STAT3 is frequently active in bronchial carcinoma, this work deals with the molecular function of the signaling protein STAT3 in KRAS mutant lung cancer in order to examine the therapeutic potential of this signal molecule in more detail.
Interestingly, Beatrice Grabner and Professor Emilio Casanova of the Ludwig Boltzmann Institute for Cancer Research, Vienna,jointly with a group of international scientists, could determine that in a mouse model STAT3 plays an essential role in the suppression of lung cancer. The reason for this is that in this model a blockade of STAT3 results in a significant deterioration and an acceleration of tumor development.
The quantification of tumor infestation of the lung as well as analyses of blood flow parameters and activation of proteins using the TissueFAXS, HistoQuest and Tissue Quest Software of TissueGnostics were also crucial to these findings. The findings, published recently in the journal Nature Communications suggest that a cancer therapy that inhibits STAT3 in cancer is questionable, as such a treatment might accelerate the progress of the disease and reduce the survival rate of patients. A close monitoring of the status of STAT3 and differential diagnosis would be an important step in order to test a secure STAT3 therapy.
Clinical improvement in psoriasis with specific targeting of interleukin-23
TissueGnostics has the great pleasure to bring to your attention the publication of this Clinical Phase I study in NATURE. TissueFAXS was a core element in the experimental protocols and analytical workflows in this clinical study! In this paper a new treatment for moderate-to-severe psoriasis is demonstrated with great success! At present, the clinical phase II is already in progress. The study was headed by the Department of Dermatology, Medical University of Vienna – more precisely by the group of Dr. Tamara Kopp and Dr. Christine Bangert, both experienced TissueFAXS users. International co-authors of this study come from the Orlando Clinical Research Center, Florida, and the pharmaceutical company Merck & Co, New Jersey, USA. This paper is an excellent demonstration of how TissueGnostics’ technology can assist top-level clinical research by generating reproducible high-quality data!
TissueGnostics introduces the Tissue Sociology concept
A cell in tissue plays a defined role as being a member of a small cell subunit within a larger organic structure. The development and differentiation of a given cell is defined by the parent cell and the local cell neighbourhood and environment. Consequently, the analysis of cells in their local environment is of major importance.
StrataQuest analysis software contains specific image processing tools for the characterization of the social situation of cells in tissue. Apart from distance measurements there are tools to identify relationships of specific cells by selecting all cells in a local neighbourhood or functional group as a separate population.
In today's newsletter we would like to present how the Tissue Sociology concept can be adapted to other existing powerful analysis methods with StrataQuest. ...
The TissueFAXS 200 workflow is optimised to efficiently handle the scanning and management of up to 200 slides. It features two scanning modes: Standard and Configurable. In the configurable mode slides can be grouped together for the application of different scanning templates.
New software diagnoses cancer cellsScientists at Vetmeduni Vienna, the Medical University of Vienna, the Ludwig Boltzmann Institute for Cancer Research, and the company Tissuegnostics, came together to create software that reliably diagnoses cancer cells by specifically identifying cell structures and proteins. They conducted a study using the software and it was recently published in the journal Plos One.
When deciding what cancer therapy a patient needs, a pathologist usually analyzes organs and tissues under a microscope, but two independent pathologists agree with each other for only one out of every three diagnoses, according to the study. “We observed a relatively high user dependent variation despite the fact that the pathologists were excellently trained experts in the field,” Dr. Lukas Kenner, one of the chief investigators in the study, wrote to DOTmed News.
TissueGnostics in the Gulf regionIn the last few weeks we made a visit to one of our customers in Gulf region. Our customer is the King Hamad Hospital in Manama, Bahrain and it is the best Automation-Reference-System in the Middle East. They purchased HemoFAXS in 2010 and since 2012 it is running in the daily hematology routine. We fine-tuned our classificator that it meets the characteristics of the smear type and staining provided from the slide maker and the auto-stainer that is used in King Hamad Hospital. King Hamad Hospital became very recently our first reference centre for HemoFAXS in the Gulf region. The HemoFAXS is connected in addition to an extra large 42" LED Monitor so that all cells found and classified by HemoFAXS can be seen constantly by the entire stuff in the lab and all visitors. We are always happy with present and future HemoFAXS fans as these.
Leading Vienna Medical Technology Company TissueGnostics establishes its position in the European top fieldTissueGnostics celebrates its 10 year anniversary with the admission in the elite group of companies formed around leading universities whose objectives are to redefine the European Digital Pathology and Diagnostics. The Vienna-based company TissueGnostics is celebrating twice this year! On the one hand it celebrates its 10-year anniversary and looks back at EUR 14.5 million total sales in 25 countries. There are already 320 digital workstations equipped with TissueGnostics licenses in the world. On the other hand, the company was able to secure a place in the top field of the European diagnostics market – as of 1st November 2013 TissueGnostics has been part of a European consortium formed by leading universities and companies in the field of digital pathology. The consortium comprises the EU Member States United Kingdom, Ireland, Italy, Spain, Romania, Lithuania and Austria – with Vienna-based TissueGnostics representing Austria within this selective consortium. The EU-funded multi-million Euro project AIDPATH - Academia and Industry Collaboration for Digital Pathology - aims at establishment of world-leading methods and techniques in digital – i.e. computer based – pathology and diagnostics. These developments will be validated by clinical trials towards the end of the 4-year project duration in order to insure a timely market placement and economic implementation. With TissueGnostics, Vienna once again proves to be not only at the geographical center of Europe, but at the very heart of innovation for the 21st Century.
New collaborationTissueGnostics is happy to announce the start of a collaboration with RI Life Sciences, UK, a renowned manufacturer of powerful state-of-the-art micromanipulation systems!
We would like to invite you to an Update on Methods in Image Cytometry and Micromanipulation – two days of workshop on March 11th, and March 13th, 2014, hosted by Dr. Marion Gröger from the Imaging Unit at the Anna Spiegel Forschungsgebäude, next to the General Hospital of Vienna (AKH).
Annual Report 2012 Medical University Innsbruck ResearchProfound Insight into our Cells
End of 2012 an existing microscope system was upgraded to a TissueFAXS-plus System at the University Clinic for Otolaryngology. Amongstothers this also comes into use in the individualized tumor therapy and in the inner ear research.
For many scientific questions and for the patient-related diagnosis, tissue sections have to be obtained to visualize specific proteins or DNA/RNA sequences The microscope system of the Vienna Company TissueGnostics digitizes in high resolution up to eight microscopic slides automatically. Based on the nuclear staining the analysis software recognizes the cell, and can assign specific staining to various cell types.
The high speed and reliability of this system allows cell based evaluations, without the requirement of individual cells being dissolved in liquids. Instead the tissue is considered and analyzed as a whole.Whole sections are rapidly digitized by the calibrated system. Therefore the overview of the whole sample is obtained, making it possible to zoom-in to the maximum at any location required. Thanks to the fast scanning process and automated analysis, even smaller research groups manage to raise more extensive projects and generate representative data.
The microscope system is applied in the individualized cancer therapy. Consequently Dr. Jozsef Dudas could locate ten cell markers for tumors in the ENT Area, showing a predictive value for subsequent therapy. The data gained under the microscope define tumor characteristics of therapeutic relevance and allow an even more targeted treatment.Only after this step the decision for surgery, radiation, chemo-or immunotherapy will be taken.
Microwave assisted tissue embedding and fully automated immune staining, allow results within two days and reduce the waiting time for diagnosis. The automated analysis of tumor markers with TissueFAXS is being established. When finalized it shall thus reduce diagnosis time and increase reliability. Also in the inner ear research field the TissueFAXS comes into use. The research team of Prof. Dr. Annelise Schrott-Fischerand Dr. Rudolf Glückert focuses on the fundamental basics of listening, attempts better understanding in hearing impairment and tries to open up new therapeutic options.
Using state-of-the-art nanoparticle technology the researchers intend to deliver drugs directly to target cells and therefore reduce asmuch as possible harmful side effects in the inner ear and the body. Such a targeted and local deployment of drugs permits the application of highly effective substances, such as, for example, nerve growth factors.
We are happy to announce that TissueGnostics is a member of the AIDPATH Project.
AIDPATH is a Digital Pathology Project with more than 3 Mio EURO funding within the 7th Framework Program of the EU. Aims of AIDPATH are the development of tools that improve and facilitate digital pathology (including new self-adjusting display technologies, new image analysis algorithms, improved image storage- and telepathology-standards).
All developments will be validated by clinical studies carried out by the academic partner institutions towards the end of the project.
The constituting members of the AIDPATH network are:
The Academic Partners:
• University of De Castilla-La Mancha, Spain
• The University of Nottingham, UK
• University of Udine, Italy
• University of Medicine & Pharmacy, Iasi, Romania
• Health Service (Servicio De Salud) De Castilla La Mancha, Spain
• University Hospital Santariskes Clinics, Vilnius, Lithuania
• Loughborough University, UK
The Industrial Partners:
• Astra Zeneca, UK
• Barco NV, Belgium
• Leica Microsystems, Ireland
• TissueGnostics, Austria
Infliximab induces downregulation of the IL-12/IL-23 axis in 6-sulfo-LacNac (slan)1 dendritic cells and macrophages
Dr. Brunner from the Medical University of Vienna, Department of Dermatology used TissueFAXS and TissueQuest to investigate the effect of anti-TNF-alpha antagonist therapy infliximab in patients with psoriasis.
Dr Brunner and his group reported that up to 48 hours after the intravenous administration of the TNFalpha antagonist infliximab, they encountered no overt changes in numbers of TNF-a1 cells or signs of apoptosis in lesional psoriatic skin. Yet they observed a rapid decrease in IL-12p40, IL-1b, CCL20, and IL12RB1 mRNA levels. They concluded that the decrease in tissue inflammation during anti–TNF-alpha therapy is not due to immediate killing of TNF-alpha–producing cells but rather results from a rapid downregulation of the pathogenic IL-12/IL-23–driven immune response.
(J Allergy Clin Immunol 2013)
Dear valued distribution partners around the globe,
TissueGnostics is proud to announce that we now offer two new devices that complement our TissueFAXS/HistoFAXS as well as HemoFAXS product lines:
1. Cell Stainer to automate immunological staining procedures and thereby greatly improve staining quality! Needless to mention that an improved staining quality will also create an improved quality of analytical data in our image analysis applications (HemoFAXS, TissueQuest, HistoQuest, StrataQuest)
2. Cellspin centrifuge for harvesting cells in body fluidsCellspin centrifuges PDF Sheet
Cellstain stainers PDF Sheet
Clinical Laboratory of Vetsuisse, Faculty of the University of Zurich and TissueGnostics cooperation
TissueGnostics hereby announces the success of a cooperation with Prof. Dr. Regina Hofmann-Lehmann and Dr. Barbara Riond at the Clinical Laboratory of Vetsuisse Faculty of the University of Zurich, Switzerland in the field of hematology. Aim of the cooperation was to development a HemoFAXS for veterinary medicine and to train leukocyte classifiers for cat, horse and canine species. The results of a comparison study of HemoFAXS versus manual counting when analyzing canine blood smears have been summarized in an abstract with the title:
EVALUATION OF THE HEMOFAXS AUTOMATED DIGITAL WHITE BLOOD CELL DIFFERENTIATION SYSTEM FOR ITS USE IN THE CANINE SPECIES by
Barbara Riond, Martina Stirn, Vivien E. Rampling, Regina Hofmann-Lehmann Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Switzerland which will be presented at a conference in Berlin.
The HemoFAXS development teams of TissueGnostics in Vienna and Iasi congratulate!
Vetsuisse Fakultät, Universität Zürich
TissueQuest employment for the optimization of Nanoparticle quantitative tracking methods
The Department of Biochemistry and Molecular Pharmacology at the “IRCCS- Mario Negri Institute for Pharmacological Research" is a worldwide leader group in the field of pharmacokinetic and, in the last few years, it focused its attention of the fate of Nanotechnologies products (both in pharmacology and toxicology) in vitro and in vivo models. In July 2007 the Institute moved to a new building where a "mouse clinic" has been set up. To be competitive in this constantly evolving field, the mouse clinic was equippedby modern instruments for experiments of in vivo imaging in rodents ...Read More
TissueGnostics is happy to inform you that the reference publication 105 has been published
y-Gamma-Secretase Inhibitors Prevent Overgrowth of Transplanted Neural Progenitors Derived from Human-Induced Pluripotent Stem Cells
It stems from the "Center for iPS Cell Research and Application, Kyoo University”. The head of this institute is Nobel prize laureate Dr. Yamanaka!
20.06.2013- TissueGnostics distributes now the Galileo TMA CK Family
The TMA technology is a technical procedure that combines tens to hundreds of paraffin-embedded tissue specimens into a single paraffinblock. The use of relatively small tissue cores, positioned onto a unique slide, allows simultaneous histological analysis of hundreds of samples.
19.06.2013- TissueGnostics announces the launch of a New Software Suite called "StrataQuest"
TissueQuest 4.0 and HistoQuest 4.0 are the current state-of-the-art solutions for cellular analysis of tissue sections and adherent cell culture monolayers in similarity to flow cytometry.
Starting with the next product generation there will be a whole new dimension provided by our world-leading analysis applications for tissue cytometry - i.e. the ability to analyze "cellular meta-structures" or tissue formations that consist of multiple/many cells! This new product will be termed "StrataQuest".
The new TissueQuest-Strata and HistoQuest-Strata will be available for cellular analysis and meta-structure analysis!
05.06.2013- HistoQuest 3.5 and TissueQuest 4.0 analysis software give users the possibility to import and analyze images and projects generated by different types of scanners.
In case of HistoQuest 3.5 also the TissueFAXS TMA tool has been integrated into the analysis software.
- Import TissueFAXS and HistoFAXS projects
- Import projects from Hamamatsu scanner Nonozoomer
- Import projects from Mirax scanner from 3DHistec
- Import projects from Pannoramic scanner from 3DHistec
- Import projects acquired with AxioScan.Z1 from Carl Zeiss
- Import projects from Aperio ScanScope
- Import projects from Leica SN 400
05.05.2013- Automated microscopy; evaluation of the DM96 and the HemoFAXS
In 2004, the Cellavision DM96 digital microscope was introduced. Recently, TissueGnostics introduced the Hemofaxs. An automated microscope that has a comparable continuous mode to the DM96, but, in addition, is a self-learning system that combines the advantages of programmed and human intelligence offering a tailor-made cell classification for each customer.
05.04.2013- New X-Cite XLED1 speeds up fluorescence scanning.
The integration of the new X-Cite XLED1 speeds up fluorescence scanning by offering high speed switching between four different wavelengths.
This speed boost of an extra 40% can be further increased by the use of a multi-bandpass filter which is integrated into the TissueFAXS workflow.
Watch the X-Cite XLED1 video here:
20.03.2013- Brightfield and fluorescence high speed scanning
Using new, faster cameras, improved microscope control software and SSD disks, we have radically lowered scanning times both for brightfield and fluorescence samples on our TissueFAXS and HistoFAXS scanners.
Scans in brightfield can now be as fast as 47 seconds for 1 cm² using the Baumer HxG 40 c camera with an 1x adapter.
In Fluorescence, 1 cm² with 4 channels at 20x, using a 1x adapter, can be scanned in: 23 minutes, 3 seconds with the PCO Pixelfly USB at 14 Bit.
7 minutes, 2 seconds with the Hamamatsu Orca Flash 4.0 at 16 Bit.
23.11.2012– Imatinib May Help Treat Aggressive Lymphoma
31.10.2012- A new paper using the TissueFAXS System was just accepted in Clinical Cancer Research.
This study establishes the feasibility of detecting BCR activation in primary FFPE biopsy specimens of DLBCL. It lays a foundation for future dissection of signal transduction networks in DLBCL and provides a potential platform for evaluating individual tumors in patients receiving novel therapies targeting the BCR pathway.
14.10.2012– Neue Krebs-Therapie erfolgreich von Maus auf Mensch übertragen
Wissenschaftler am Ludwig Boltzmann Institut für Krebsforschung (LBI CR) und am Klinischen Institut für Pathologie der Medizinischen Universität Wien (AKH) unter der Leitung von Prof. Lukas Kenner untersuchten einen besonders aggressiven Tumor, das anaplastische großzellige Non-Hodgkin Lymphom (anaplastic large cell lymphoma – ALCL). Unter Verwendung eines genetischen Modells, das diese Erkrankung in der Maus exakt widerspiegelt konnten sie die zentrale Rolle des Schaltermoleküls PDGFR identifizieren. Ihre Ergebnisse ermöglichten dem Team um Kenner einen todkranken Patienten im Endstadium ALCL mit einem spezifischen PDGFR-Inhibitor zu behandeln. Innerhalb von nur 10 Tagen war der 27-jährige Patient tumorfrei, und führt seit mehr als 22 Monaten ein vollkommen normales Leben. Ohne diese Behandlung wäre der Patient vermutlich verstorben. Diese Ergebnisse wurden kürzlich in der renommierten Zeitschrift „Nature Medicine“ veröffentlicht.
Die Forschung wurde in Kooperation mit den folgenden Forschunginstitutionen durchgeführt: Harvard Medical School, New York University School of Medicine, University of Bologna, University of Edinburgh, University of Torino, Center for Molecular Medicine of the Austrian Academy of Sciences, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Ludwig Boltzmann Cluster Oncology, Medizinische Universität Graz, Medizinische Universität Wien, Paracelsus Medizinische Universität in Salzburg, Veterinärmedizische Universität Wien, Research Institute of Molecular Pathology. Entscheidend für Arbeit war auch die HistoQuant Technologie der Firma TissueGnostics, mit der Tumoren auf ihre molekularen Eigenschaften quantitativ untersucht wurden.
11.6.2012 – Using extended focus in TissueQuest 4.0 for RNA Dot analysis
The above presentation features one of the major gadgets, that TissueQuest 4.0 offers. By merging different z-Level images, thus creating one sharp layer image, RNA Dot analysis can be carried out quite simply and elegant.For more information regarding z-stacking and/or RNA-analysis please contact: firstname.lastname@example.org
16.5.2012 – HemoFAXS 2.0 with automated oiling and OCR at ISLH 2012“With a broad customer base all over Europe HemoFAXS has become a major contributor to the TissueGnostics product line-up. As a natural consequence we put a lot of effort into developing convenient systems for Hematology labs. The latest evolutionary step of HemoFaxs was to add automation in oiling and OCR (Optical Character Recognition), which is automated Slide-ID reading. Lab staff now only has to insert slides and press scan, which is far less time consuming than the traditional way of blood smear scanning”, says Ilyas Merl (Junior Marketing Manager, TissueGnostics) At the ISLH 2012 Congress, held in Nice (France) from 21st-24th of May, TissueGnostics launches its latest generation of Blood Analysis Systems, the HemoFAXS 2.0. Besides a magnificent increase in reliability, its major improvement is a fully automated oil dispenser, which uses the optimal amount of oil for each slide, in order to get the best image-quality from the 100x magnification objective.
Another step towards full automation was the implementation of an OCR-Device. A small camera at the top end of the microscope now takes pictures of the slide labels and recognizes automatically the slide ID of the blood smear. The ID enables HemoFAXS to get Patient Name, Ward, etc. from the LIS to make data management reporting easy. This all happens automatically.
“HemoFAXS now competes with market leaders. It is a fully functional, automated Hematology System. Boxed systems have a clear disadvantage in price, accessibility and usability. HemoFAXS is also a high-end microscope, fully functional for all major tasks microscopes need to perform”, says Georg Steiner (CEO. TissueGnostics.)
TissueGnostics will display the new HemoFAXS at booth 8/9 at the ISLH in Nice, France, held from 21st – 24th of May. Please visit the booth in the announced exhibition hours (http://www.islh.org/ISLH_2012/). If you can’t make it to Nice, please contact email@example.com for more information.
12.4.2012 – A new Vista on Disease PatternsOn the 12th of April the Symposium “Bridges in Pathophysiology” was held at the Medical University in Vienna. In the context of this meeting the completion of the interdisciplinary project “A new Vista on Disease Patterns” (FFG-project 818 094) was celebrated by different talks of experts from the Medical University in Vienna, Seewald Solutions and TissueGnostics. The Project “A new Vista on Disease Patterns” focused on the development of new algorithms for automated cell and tissue analysis. This cooperation of corporate developers (TissueGnostics and Seewald Solutions) and researchers from the Medical University of Vienna resulted in a greater understanding and appreciation for each other, and at the same time reached its goal of developing algorithms at the very edge of technology.
“The principle investigators Drs. Giovanna Bises, Theresia Thalhammer and Isabella Ellinger from the IPA/MedUniWien in collaboration with the researcher Dr. Alexander K. Seewald (Seewald Solutions) and TissueGnostics GmbH have aimed and succeeded to develop new algorithms for automated segmentation of cells that lack nuclei (erythrocytes), of multinucleated cells (Osteoclasts in culture and placental syncytiotrophoblast), of epithelial and stromal areas within colorectal tumor tissue and of the plasma membrane compartments of cells in the tissue context in this FFG and TissueGnostics-funded Bridge-project. Overall, the intention of this project was to adopt the TissueQuest software for new research challenges, allowing a broad application of the system within many basic and clinical research projects.”, says Ao. Univ. Prof. Dr. - Isabella Ellinger from the Department of Pathophysiology and Allergy Research (IPA) at the Medical University Vienna.
“With the newly developed algorithms integrated into HistoQuest and TissueQuest software, a substantially increase of the performance of our software will occur. Analysis of multi-nucleated cells or cells without nucleus will become simple and elevate the possibilities TissueGnostics offers to researchers dramatically, especially in the field of cancer research”, says Ilyas Merl, Junior Marketing Manager at TissueGnostics.
Dr. Ellinger explains: “This fruitful interdisciplinary project has resulted in the development of various algorithms based on classical image processing and machine learning techniques. This was enabled by the constant support and rapid technical adoption of the TissueFAXS hard- and software components upon any request of the developing team. By that, TissueGnostics GmbH proved to be a reliable and supportive partner for research projects. Apart from the new algorithms developed, the combined efforts of the project partners has so fare enabled publications of seven research articles, more than 17 contributions to national and international symposia and the training of 12 students, among them two PhD students involved in PhD programs of the Medical University Vienna. Not surprisingly, therefore, the professional collaboration within this team has been awarded “with one of the ‘Science2 business Awards’ in the year 2011.”, says Dr. Ellinger.
One of TissueGnostics core values is to stay close to researchers in order to implement their expertise into user-friendly and professional tools for research. The cooperation with excellent researchers, like the ones from the Medical University Vienna shows that this principle is and will be a very fruitful contribution to TissueGnostics’ development. “The work contributed by the Medical University Vienna is very valuable and crucial to the success of this project. These experts made it possible for us to gain insights into research, that only experts in the field have. We are looking forward to work with them again”, says Georg Steiner (CEO of TissueGnostics).
01.02.2012, Österreichische Medtech-Firma schreibt Geschichte des digitale Imagings neuDr. Alexandra C. Gruber talks with Katja Österreicher. Read article (German)
11.1.2012, New offices for TissueGnostics Romania and TissueGnostics USAA strong beginning for 2012 as TissueGnostics Romania and TissueGnostics USA moved to new offices. TissueGnostics ties a high level of customer satisfaction to a high level of working place comfort for its employees.
TissueGnostics Romania now accommodates a fully equipped support center and a development core unit which enforces development progress for all the TissueGnostics product lines. “Creating a specific process oriented department with the needed working environment is always a benefit for product quality and innovation”, says Georg Steiner (CEO, TissueGnostics GmbH).
TissueGnostics Support will be available world-wide and fully functional also on holidays, to give customers at all times the help they need. The support team can be reached directly at:
- USA: Tel. +1 (323) 8434024
- Europe: +40 (771) 309792
The TissueGnostics USA sales and support unit moved to its new offices at:
- TissueGnostics USA Ltd.
- 18460 Clark Street
- Tarzana, CA 91356
20.12.2011, Merry Christmas and a happy new year!!!Another year is over. A new one is about to begin. TissueGnostics says thank you to all partners, customers and friends for the fantastic year 2011. We are eager to start into 2012, which will feature several improvements of our current systems and the launch of HemoFAXS 2.0, as well as the continuation of our successful workshop-tour throughout Europe and the participation in several congresses worldwide. Let the next year roll on!
4-7-11.2011, 8th NCRI Cancer Conference, Liverpool, UK“Cancer research in Great Britain seems to have a tremendous need for software tools that simplify workflows and maintain quality levels, which ensure progress in cancer research endeavors. That is exactly where TissueGnostics fits in”, says Arndt Stenzel (Sales Representative, TissueGnostics GmbH). The 8th NCRI Cancer Conference, held in the BT Convention Center in Liverpool, turned out to be a great success for TissueGnostics. Especially the software modules HistoQuest (brightfield) and TissueQuest (fluorescence), for in depth analysis of cultivated cells and tissue , attracted a multitude of scientists and technicians.
At the NCRI conference, the new booth design was introduced. A big HD-screen in the very center , combined with a TissueFAXS plus microscope system and a HistoQuest/TissueQuest workstation offered hands-on experience for interested visitors. “The big screen gives life to the booth, as it displays what can be normally seen only on the small screens at the workstation. This way people passing, or larger groups enjoy a comfortable view on software features.
They don’t watch useless advertisement images. They can see how our software works and then decide whether it is interesting for them” (Georg Steiner, CEO, TissueGnostics GmbH) For more information on congresses and shows attended by TissueGnostics please visit: Congress
6.5.2011 - Phoenix, ArizonaAt the 71st Annual Meeting of the Society for Investigative Dermatology Georg Steiner (CEO of TissueGnostics USA Ltd.) was invited to participate as a lecturer at the Confocal Microscopy and Imaging Techniques-Workshop.
His 20 min presentation featured a wide spectrum of issues concerning image processing from staining to the actual analysis and result interpretation.
Mr. Steiner used HistoQuest Software to analyse a tissue sample with Langerin positive cells and TissueQuest Software for a fluorescence skin sample (UV Irradiation of Skin) in order to cover the principles of:
- 1. Correct staining protocols
- 2. Acquisition of images
- 3. Shading correction
- 4. Definition of Regions of Interest (ROI)
- 5. Color separation
- 6. Segmentation
- 7. Measurement of various parameters
- 8. Comparison of data
“Discussing these essential steps with an audience of scientists, who will definitely use the information given to them, and showing them the capabilities and user friendliness of our TissueGnostics products, was a great experience which already has borne fruits, as we got in contact with people benefiting from our analysis tools”, says Georg Steiner.
If you are interested in the presentation or want to have a web-presentation of the lecture, or if you have any questions on TissueQuest-/HistoQuest Software please contact: firstname.lastname@example.org
We would also like to thank Dr. Christine Bangert (Department of Dermatology, Medical University Vienna) for providing the TissueFAXS data used in this presentation.
04.05.2011 - Using HistoQuest for scientific publicationsTissueGnostics puts a lot of effort into making its products simple to use but at the same time providing the necessary tools for state-of-the-art scientific research.
The latest publication: Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets. (Kounnis V, Ioachim E, Svoboda M, Tzakos A, Sainis I, Thalhammer T, Steiner G, Briasoulis E) is already Nr. 53 of the official publication list of TissueGnostics. Download Full Publication List
HistoQuest was successfully used in order to quantify expression of organic anion-transporting polypeptides (OATP) 1A2, 1B1 and 1B1/1B3. Conclusion was that because of the high expression of OATPs 1A1, 1B1 and 1B3 in pancreatic adenocarcinoma further research efforts toward novel therapeutics targeting OATPs is justified. (For full abstract please visit: http://www.dovepress.com/expression-of-organic-anion-transporting-polypeptides-1b3-1b1-and-1a2--peer-reviewed-article-OTT)
“In this publication, HistoQuest is used in a proper way to compare antigen density. The presentation clearly indicates what is measured, and where the density is measured. It also shows that HistoQuest provides all necessary tools and features, combined with high quality graphic support material, to produce “ready-for-publication” output!”, (Georg Steiner, CEO TissueGnostics)
27.02.-03.03.2011 -TissueGnostics at the 100th Annual Meeting of the United States & Canadian Academy of Pathology100 years of expertise in Pathology for the United States and Canada. 100 years of annual meetings of the United States and Canadian Academy of Pathology. For the 100th Meeting TissueGnostics went in for a special treat. Matthew Tolmachoff and Georg Steiner (CEO) put up an 18 sqm booth, including a TissueFAXSi plus system and a workstation equipped with TissueQuest and HistoQuest. Displaying the innovative solutions for cell and tissue analysis to an audience of hundreds of experts from all over the world resulted in many interesting conversations and new contacts..
“We had a very productive time, while talking to our current and our future customers. Talking to these scientists at this conference is always a great experience, as all experts in the field of Pathology join together at this meeting.”, Georg Steiner (CEO TissueGnostics)
There was also some sweat on set, as some of the booth equipment arrived late, making building up time quite short. However, it all paid of.
The big booth and the products presented combined with lots of interested scientist made USCAP meeting 2011 a full success. You will find TissueGnostics in 2012 at USCAP again.
For a list of our planned and past congresses please press here.
08.03.2011 -International Women’s DayInternational Women’s Day: TissueGnostics’ authorized officer Katja Österreicher at Austrian Federal Minister of Science and Research Beatrix Karl for International Women’s day.
“Highly qualified women are essential for innovation. We have to tap the potential of women working at the crossroads of Science and Economy even stronger in the future, and make it visible”, is the Minister convinced. This is also a part of economical recovery, growth and the creation of new high quality jobs.
Together with 10 women being experts in the field of Science- and Technology-Transfer-Business, Katja Österreicher (Authorized officer at TissueGnostics Austria) was invited to participate at a breakfast and a group discussion at the Austrian Ministry for Science and Research in Vienna. The discussion topic was “Strenghtening women in Science and Technology-Transfer” The current situation and challenges and solutions for the support of women in Science and Research were thoroughly discussed.
“The passing on of personal experience is really important, in order to strengthen women and fully intergrate them into Science-, Economy- and Innovations-politics!”, was the conclusion of Beatrix Karl after the meeting.
Katja Österreicher is co-founder of TissueGnostics GmbH and currently holds the position of an authorized officer at TissueGnostics. She is also mother of a 3 year old daughter.
Link to the Article; Austrian Ministry of Science and Research:
01 - 03.12.2010
Global TissueGnostics Distributor Meeting 2010
This year the Global TissueGnostics (TG) Distributor Meeting 2010 added to this experience as 17 participants from Japan, China, Korea, Singapur, Taiwan, Australia, France, Switzerland, Czech Republic, Slowakia, Lithuania, Turkey, UK and Ireland, visited the TissueGnostics (TG) headoffice in Vienna for 3 days of special training.
TG-CEO Dr. Rupert Ecker introduced the distributors not only to each other but encouraged them to share experiences and give feedback on their endeavours. TG-staff mingled with the global TG-distributors and shared the latest developments on HistoQuest- and TissueQuest softwares. “On the whole the purpose was to get together as much experiences and information and start off a global network for the benefit of TG-customers around the world.”, says Dr. Ecker, ”Customers will see a difference as problems will be addressed earlier and solved faster as user feedback is a major input for our current and future software-development.”
Jörg Schlegel from BioInnovas AG (Switzerland), the newest member of the TG-distributiors family also acknowledged: “For me it was very important to get to know the other distributors, especially the Taiwanese, as they have been successful for quite some time.” BioInnovas and TissueGnostics announced partnership for the Swiss area at the beginning of December 2010.
The strong training sessions during the day were followed by visits to traditional Christmas markets and typical Viennese restaurants. All participants enjoyed themselves and prepared for a strong and successful year 2011. Let the new year roll on…
22 - 24.8.2010
TissueGnostics at 14th International Congress of Immunology (ICI) in Kobe
„I am happy to announce that this was the most successfull congress, I have ever attended.“ Rupert Ecker, CEO, TissueGnostics GmbH
From 22nd to 24th of August the 14th International Congress of Immunology took place in Kobe, Japan.TissueGnostic`s CEO Rupert Ecker, together with TG distributors from Japan, Korea, Taiwan and China were highly motivated for the exhibition at the Kobe International Exhibition Hall with its 6000 participants.
However, even their most optimistic expectations were exceeded. Equiped with 10 different types of product folders in Japanese, Korean, Mandarin, Traditional Chinese and English and with 12 exhibitors at the booth the TG team was constantly doing their best to inform, present and explain. „Already on the 2nd day the English folders ran out, fortunately we had some bi-lingual Chinese/English folders…By the end of the congress all of the contact forms were gone“, so Mr. Ecker after the Congress.
Main focus of the TissueGnostics booth was TissueFAXS, HistoFAXS and HemoFAXS. HemoFAXS offers fully automated analysis and classification of Leukocytes (white blood cells) based on advanced Support Vector Machine Technology.
TissueFAXS is a cell and tissue imaging and analysis system for fluorescence analysis. HistoFAXS does the same in brightfield. Due to superb, patented algorithms TissueGnostics systems are in use all over the world.